초록

Novel platinum(II) complexes of 1,2-diaminocyclohexane, 1-aminomethylcyclooctylamine and 1,2-diamino-2,4-dimethylpentane are provided. Such complexes are of use in inhibiting the growth of certain mammalian tumors.

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1. A compound of the formula ##STR## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans(+) or trans(-) and R 1 and R 2 when taken together represent a group of the formula ##STR## 2. A compound of the formula ##STR## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, tr

1. A compound of the formula ##STR## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans(+) or trans(-) and R 1 and R 2 when taken together represent a group of the formula ##STR## 2. A compound of the formula ##STR## wherein the stereoisomerism of 1,2-diaminocyclohexane is cis-, trans(+) or trans(-) and R 1 and R 2 are both ##STR## R 1 and R 2 when taken together represent a group of the formula ##STR## 3. A compound of the formula ##STR## wherein the stereoisomerism of 1,2-diaminocyclohexane is trans(-) and R 1 and R 2 when taken together represent a group of the formula ##STR## 4. A compound of the formula ##STR## wherein the stereoisomerism of 1,2-diaminocyclohexane is trans(-) and R 1 and R 2 are both ##STR## R 1 and R 2 when taken together represent a group of the formula ##STR## 5. A compound of claim 2 wherein R 1 and R 2 are both ##STR## 6. A compound of claim 2 wherein R 1 and R 2 are both ##STR## 7. A compound of claim 2 wherein R 1 and R 2 are both ##STR## 8. A compound of claim 1 wherein R 1 and R 2 when taken together represent ##STR## 9. A compound of claim 1 wherein R 1 and R 2 when taken together represent ##STR## 10. A compound of claim 1 wherein R 1 and R 2 when taken together represent ##STR## 11. A compound of claim 2 wherein R 1 and R 2 when taken together represent ##STR## 12. A compound of claim 1 wherein R 1 and R 2 when taken together represent ##STR## 13. A compound of claim 1 wherein R 1 and R 2 when taken together represent ##STR## 14. A compound of claim 1 wherein R 1 and R 2 when taken together represent ##STR## 15. A compound of claim 1 wherein R 1 and R 2 when taken together represent ##STR## 16. A compound of claim 4 wherein R 1 and R 2 are both ##STR## 17. A compound of claim 4 wherein R 1 and R 2 are both ##STR## 18. A compound of claim 4 wherein R 1 and R 2 are both ##STR## 19. The compound of claim 3 wherein R 1 and R 2 when taken together represent ##STR## 20. The compound of claim 3 wherein R 1 and R 2 when taken together represent ##STR## 21. The compound of claim 3 wherein R 1 and R 2 when taken together represent ##STR## 22. The compound of claim 4 wherein R 1 and R 2 when taken together represent ##STR## 23. The compound of claim 3 wherein R 1 and R 2 when taken together represent ##STR## 24. The compound of claim 3 wherein R 1 and R 2 when taken together represent ##STR## 25. The compound of claim 3 wherein R 1 and R 2 when taken together represent ##STR## 26. The compound of claim 3 wherein R 1 and R 2 when taken together represent ##STR##