초록 ▼

Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as na

Infection-resistant materials, and methods of preparing same, suitable for use within the interior of a human or animal body in such forms as vascular grafts prostheses, or other implanted devices. The material is rendered infection-resistant by incorporating therein antimicrobial agents, such as nalidixic acid derivatives or metal salts of nalidixic acid derivatives. In particular illustrative embodiments, silver norfloxacin and silver pefloxacin, are complexed with natural or synthetic polymeric materials such as silk, polyester (e.g., Dacron), polyurethane, polytetrafluoroethylene, or silicone-based material, to provide long-term prevention of infections which may otherwise result during or after surgery or implantation of a device.

대표청구항 ▼

Infection-resistant material for use within the interior of a human or animal body comprising a polymeric substrate provided with an effective amount of at least one antimicrobial agent; said antimicrobial agent bearing a nalidixic acid derivative having the general formula: [Figure] wherein X is a

Infection-resistant material for use within the interior of a human or animal body comprising a polymeric substrate provided with an effective amount of at least one antimicrobial agent; said antimicrobial agent bearing a nalidixic acid derivative having the general formula: [Figure] wherein X is a halogen; A is a carbon or nitrogen atom; R1 is hydrogen, a lower alkyl group or a metal; R2 is a lower alkyl group, a lower aralkyl group, a vinyl group, an allyl group, a lower hydroxy alkyl group or a halogenated lower alkyl group; R3 and R4 are hydrogen, a lower alkyl group or together, along with the nitrogen atom to which they are attached, form a 5- or 6-membered heterocyclic ring containing the nitrogen atom and additionally a second nitrogen or oxygen heteroatom.