Analgesic and anti-inflammatory compositions comprising xanthines and methods of using same
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/19
A61K-031/52
출원번호
US-0560460
(1983-12-12)
발명자
/ 주소
Sunshine Abraham (New York NY) Laska Eugene M. (Larchmont NY) Siegel Carole E. (Mamaroneck NY)
출원인 / 주소
Analgesic Associates (Larchmont NY 02)
인용정보
피인용 횟수 :
19인용 특허 :
0
초록▼
Novel analgesic and anti-inflammatory compositions of matter for use in eliciting an analgesic or anti-inflammatory response, said compositions comprising xanthine together with a selected non-narcotic analgesic/nonsteroidal anti-inflammatory drug or a selected narcotic analgesic, or both, are discl
Novel analgesic and anti-inflammatory compositions of matter for use in eliciting an analgesic or anti-inflammatory response, said compositions comprising xanthine together with a selected non-narcotic analgesic/nonsteroidal anti-inflammatory drug or a selected narcotic analgesic, or both, are disclosed. When used in combination with the selected drugs, such xanthine enhances the analgesic or anti-inflammatory response and also hastens its onset.
대표청구항▼
A method of eliciting an onset hastened and enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism: (i) an analgesically and anti-inflammatorily effective amount of benoxaprofen, flurbiprofen, fenbufen, ketoprofe
A method of eliciting an onset hastened and enhanced analgesic and anti-inflammatory response in a mammalian organism in need of such treatment, comprising administering to such organism: (i) an analgesically and anti-inflammatorily effective amount of benoxaprofen, flurbiprofen, fenbufen, ketoprofen, pirprofen, carprofen, oxaprozin, pranoprofen, miroprofen, tioxaprofen, suprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid, or pharmaceutically acceptable salts thereof, and (ii) an amount of xanthine derivative sufficient to hasten the onset of and enhance the analgesic and anti-inflammatory response of component (i), said xanthine derivative having the formula: [Figure] (I) or a pharmaceutically acceptable non-toxic salt thereof wherein R1-R3, inclusive, independently represent hydrogen, C1-C6alkyl, C1-C6alkoxy, C1-C6haloalkyl, C3-C6cycloalkyl, hydroxy (C1-C6)alkyl, halogen, hydroxy(C1-C4)alkylamino(C1-C4)alkyl, C1-C4(dialkyl)amino(C1-C4)alkyl, C1-C4alkylcarbonyl(C1-C4)alkyl, C1-C6alkylamino, C1-C6(dialkyl)amino, indolyl, phenyl or allyl: R4 is hydrogen, C1-C6alkyl, halo(C1-C6)alkyl, C1-C6alkylamino, C1-C6alkylthio, nitro, carboxy C1-C6(dialkyl)amino, C3-C6cycloalkyl, phenyl, naphthyl, ar(C1-C4)alkyl, or a group of the formula [Figure] (II) where R5 is halo, C1-C6alkyl, C1-C6alkoxy, C1-C6alkylthio, nitro or C1-C6alkylamino, and n is 1, 2 or 3 with the proviso that R1, R2 and R3 cannot all be C1alkyl when R4 is hydrogen.
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이 특허를 인용한 특허 (19)
Baraldi,Pier Giovanni; Borea,Pier A., 8-Heteroaryl xanthine adenosine Areceptor antagonists.
Burch, Ronald M.; Goldenheim, Paul D.; Sackler, Richard S., Analgesic combination of oxycodone and N-[3-(formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl] methanesulfonamide.
Jacobson Kenneth A. ; Karton Yishai,ILX ; Gallo-Rodriguez Carola ; Fischer Bilha ; van Galen Philip J. M. ; Maillard Michel, S-substituted 1,3,7-trialkyl-xanthine derivatives.
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