초록 ▼

An absorbable biologically compatible putty-like composition is used as a matrix from which immunologically or pharmacologically active agents, such as antibiotics, can be introduced into the body to provide a slow sustained release of the agent over an extended period of time. A preferred matrix co

An absorbable biologically compatible putty-like composition is used as a matrix from which immunologically or pharmacologically active agents, such as antibiotics, can be introduced into the body to provide a slow sustained release of the agent over an extended period of time. A preferred matrix comprises a mixture of calcium stearate, dextran and castor oil.

대표청구항 ▼

In a peridontal desease gum treating method for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time to infected or target area pockets between the base of a tooth and the adjoining periodontal tissues, which comprises a com

In a peridontal desease gum treating method for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time to infected or target area pockets between the base of a tooth and the adjoining periodontal tissues, which comprises a combination of (a) from 0.25% to 50% by weight of the composition of a pharacologically or immunologically active agent in an effective depot amount greater than the single dose amount, and (b) a matrix which is minimally reactive towards body tissue and which is absorbable in the body over an extended period of time without adverse body reaction; the improvement comprising employing as said matrix dispensed in the shape of a rod, pellet, disc or tiny gum drop, to a pocket formed by teasing the gum away from the tooth an absorbable composition comprising: (i) a component (A) comprising a mixture of calcium stearate and dextran in which said mixture comprises between about 35% and about 60% by weight of said calcium stearate based on the weight of the matrix and between about 10% and about 35% by weight of dextran, based on the weight of the matrix; and the remainder of the matrix comprising (ii) a component (B) comprising a biocompatible base consisting of a natural or synthetic oil or wax which is absorbable in the body, said composition having a putty-like consistency at room and body temperatures.