초록 ▼

Percutaneous administration of nicotine in a dose approximating the dose delivered by a variety of nicotine-containing products, such as cigarettes, cigars, snuff and chewing tobacco, is carried out using an occlusive pad. The nicotine is delivered so as to mimic the pharmacological effects of nicot

Percutaneous administration of nicotine in a dose approximating the dose delivered by a variety of nicotine-containing products, such as cigarettes, cigars, snuff and chewing tobacco, is carried out using an occlusive pad. The nicotine is delivered so as to mimic the pharmacological effects of nicotine provided by the conventional use of tobacco, and a therapeutic function is achieved by reducing or eliminating the need for the tobacco product. A suitable transdermal application pad comprises a reservoir for liquid nicotine base to be affixed to the skin in a variety of places. Due to the high lipid solubility and resultant high skin permeability of nicotine, vehicles or solvents are not generally needed to enhance dermal absorption.

대표청구항 ▼

A method of administering nicotine for the purpose of satisfying a nicotine habit while minimizing or eliminating side effects caused by absorbing nicotine through the lungs along with products of combustion of tobacco, comprising transdermally administering nicotine via an occlusive pad adhered to

A method of administering nicotine for the purpose of satisfying a nicotine habit while minimizing or eliminating side effects caused by absorbing nicotine through the lungs along with products of combustion of tobacco, comprising transdermally administering nicotine via an occlusive pad adhered to the skin at a dosage rate sufficient to satisfy said nicotine habit, said occlusive pad comprising a nicotine-impermeable backing and nicotine-permeable, porous, inert membrane, said nicotine impermeable backing and said nicotine-permeable membrane defining a cavity therebetween, said cavity containing liquid nicotine therein.