초록 ▼

A novel hydrophilic anionic charge modified microporous filter membrane is provided comprising an organic polymeric microporous filter membrane having a micro-structure throughout the membrane and a modifying amount of an anionic charge modifying agent bound to substantially all of the membrane micr

A novel hydrophilic anionic charge modified microporous filter membrane is provided comprising an organic polymeric microporous filter membrane having a micro-structure throughout the membrane and a modifying amount of an anionic charge modifying agent bound to substantially all of the membrane micro-structure without substantial pore size reduction or pore blockage. The invention is further directed to a process for anionically charge modifying an organic polymeric microporous filter membrane by applying to the membrane the charge modifying agent, preferably, by contacting the membrane with a solution of the charge modifying agent. The anionic modified microporous membrane of this invention may be used for the filtration of fluids, particularly parenteral or biological liquids contaminated with charged particulates, and for plasmapheresis, particularly in the form of hollow fiber tubes. The membrane has low extractables and is sanitizable or sterilizable.

대표청구항 ▼

A process for filtration of liquid having cationic particulate contaminants therein, comprising passing the liquid through a skinless hydrophilic anionic charge modified microporous filter membrane comprising: a skinless hydrophilic organic polymeric microporous filter membrane having an internal mi

A process for filtration of liquid having cationic particulate contaminants therein, comprising passing the liquid through a skinless hydrophilic anionic charge modified microporous filter membrane comprising: a skinless hydrophilic organic polymeric microporous filter membrane having an internal microstructure throughout said membrane, and a charge modifying amount of an anionic charge modifying agent bonded to substantially all of the membrane microstructure without substantial pore size reduction or pore blockage, wherein the charge modifying agent is a water soluble polymer having substituents thereon capable of bonding to the membrane and anionic functional groups, wherein the anionic functional groups are selected from the group consisting of carboxyl, phosphonous, phosphonic, sulfonic groups or mixtures thereof and modify the zeta potential of the membrane, whereby the cationic particulate contaminants are captured by the anionic charge modified microporous membrane and substantially removed from the liquid.