초록 ▼

A process to produce by covalent binding conjugates of a substance containing a 2-amino-2-deoxyglycopyranosyl residue the NH2-function of which in its most stable conformation is equatorially oriented, and a substrate containing a primary amino group. This is done by subjecting the substance to degr

A process to produce by covalent binding conjugates of a substance containing a 2-amino-2-deoxyglycopyranosyl residue the NH2-function of which in its most stable conformation is equatorially oriented, and a substrate containing a primary amino group. This is done by subjecting the substance to degradation by diazotation to form a substance fragment having a free terminal aldehydo group, said fragment through its aldehydo group being reacted with the amino group of the substrate to form a Schiffs base which is then by reduction converted to a secondary amine. The substance is preferably selected from oligo and polysaccharides containing glucosamine or galactose amine units. The substrate is suitably selected from surface-aminated plastic objects, aminated gels and proteins. The conjugate described consists of a 1-deoxy-2,5-anhydrohexitol unit which constitutes terminal unit in an oligo or polysaccharide and which in 1-position is covalently bound to an amino group associated with a substrate.

대표청구항 ▼

A conjugate comprising a 1-deoxy-2,5-anhydrohexitol unit which constitutes the terminal unit in a substance selected from the group consisting of heparin, deacetylated dermatan sulfate, chitosan, and deacetylated hyaluronic acid, which substance is covalently bound in the 1-position to an amino grou

A conjugate comprising a 1-deoxy-2,5-anhydrohexitol unit which constitutes the terminal unit in a substance selected from the group consisting of heparin, deacetylated dermatan sulfate, chitosan, and deacetylated hyaluronic acid, which substance is covalently bound in the 1-position to an amino group associated with a substrate, wherein said substrate is selected from the group consisting of polyvinyl chloride, polyethylene, sepharose and antithrombin.