초록 ▼

Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a loc

Surgical implants, especially endoprosthetic orthopaedic implants and sutures, are rendered antimicrobial by the presence of a bioerodible metallic silver component, especially a surface coating, which provides in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue. Latently bioerodible silver components of an implant can be activated by, for example, abrasion, heating to above about 180°C. or, especially, contact with hydrogen peroxide.

대표청구항 ▼

A method of prophylactic treatment of post-operative infection following endoprosthetic implant surgery, said method comprising: selecting an endoprosthetic implant comprising a permanent implant structure formed of substantially bioinert structural material providing permanent mechanical integrity

A method of prophylactic treatment of post-operative infection following endoprosthetic implant surgery, said method comprising: selecting an endoprosthetic implant comprising a permanent implant structure formed of substantially bioinert structural material providing permanent mechanical integrity to the implant and a latently bioerodible metallic silver component deposited in or on a permanent implant structure, contacting said selected insert with hydrogen peroxide to render the metallic silver component thereof bioerodible to provide in vivo sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue, subsequently washing the implant free of hydrogen peroxide, and thereafter surgically implanting the thus activated implant in a human or animal body. A method of rendering antimicrobial an endoprosethetic implant comprising a permanent implant structure formed of a substantially bioinert structural material providing permanent mechanical integrity to the implant, and a latently bioerodible metallic silver component deposited in or on the permanent implant structure, said method comprising: contacting said implant with hydrogen peroxide to render said silver component bioerodible to provide in vivo a sustained release of silver ions in a concentration sufficient to provide a localized antimicrobial effect but insufficient to cause significant damage to connective tissue and, subsequently washing the implant free of hydrogen peroxide before implanting.