New triazine derivatives represented by the formula: [Figure] (I) wherein R1 is aryl, pyridyl, thienyl, 1,2,3,4-tetrahydroquinolyl or 1,3,4,5-tetrahydro-2H-1-benzazepinyl, optionally substituted with lower alkyl, lower alkoxy, halogen, nitro or oxo, R2 is hydrogen, lower alkyl or carbamoyl substitut
New triazine derivatives represented by the formula: [Figure] (I) wherein R1 is aryl, pyridyl, thienyl, 1,2,3,4-tetrahydroquinolyl or 1,3,4,5-tetrahydro-2H-1-benzazepinyl, optionally substituted with lower alkyl, lower alkoxy, halogen, nitro or oxo, R2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl, and Z is a group selected from [Figure] and pharmaceutically acceptable salt thereof, processes for preparation thereof and pharmaceutical compositions comprising the same of antihypertensive and antithrombotic activity.
대표청구항▼
A compound of the formula: [Figure] wherein R1 pyridyl, thienyl, 2-oxo-1,2,3,4,-tetrahydroquinolyl or 2-oxo-1,3,4,5-tetrahydro-2H-1-benazepinyl optionally substituted with lower alkyl, lower alkoxy, halogen, or nitro; R2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)
A compound of the formula: [Figure] wherein R1 pyridyl, thienyl, 2-oxo-1,2,3,4,-tetrahydroquinolyl or 2-oxo-1,3,4,5-tetrahydro-2H-1-benazepinyl optionally substituted with lower alkyl, lower alkoxy, halogen, or nitro; R2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl wherein ar is phenyl, xylyl, tolyl or naphthyl; R3 is hydrogen or ar(lower)alkyl wherein ar is phenyl, tolyl, xylyl or naphthyl; R5 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl wherein ar is phenyl, tolyl, xylyl or naphthyl; and X is O or S, and pharmaceutically acceptable salt thereof.
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이 특허에 인용된 특허 (5)
Brown David (Macclesfield GB2) Hargreaves Rodney B. (Poynton GB2) McLoughlin Bernard J. (Macclesfield GB2) Mills Stuart D. (Macclesfield GB2), 1,2,4-Triazin-3(2H) ones.
Brown David (Macclesfield GB2) Dowell Robert I. (Congleton GB2) Hargreaves Rodney B. (Poynton GB2) Main Brian G. (Sandbach GB2), 6-Aryl-1,2,4-triazin-6-ones which possess cardiotonic properties.
Gullo James M. (Perry OH) Heilman William P. (Chagrin Falls OH) Wayner Robert J. (Fairport Harbor OH) Moser Robert E. (Mentor OH), Pharmacologically active substituted 1,2,4-triazines.
Hohlweg, Rolf, 3-(1,3-benzodioxol-5-yl)-6-(4-cyclopropylpiperazin-1-yl)-pyridazine, its salts and solvates and its use as histamine H3 receptor antagonist.
Michelotti Enrique Luis ; Egan Anne Ritchie ; Ross ; Jr. Ronald ; Wilson Willie Joe, Dihydropyridazinones, pyridazinones and related compounds as fungicides.
Brooks Dee W. (Libertyville IL) Basha Anwer (Lake Forest IL) Gunn Bruce P. (Island Lake IL) Bhatia Pramila A. (Mundelein IL), Triazinone lipoxygenase compounds.
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