초록 ▼

New triazine derivatives represented by the formula: [Figure] (I) wherein R1 is aryl, pyridyl, thienyl, 1,2,3,4-tetrahydroquinolyl or 1,3,4,5-tetrahydro-2H-1-benzazepinyl, optionally substituted with lower alkyl, lower alkoxy, halogen, nitro or oxo, R2 is hydrogen, lower alkyl or carbamoyl substitut

New triazine derivatives represented by the formula: [Figure] (I) wherein R1 is aryl, pyridyl, thienyl, 1,2,3,4-tetrahydroquinolyl or 1,3,4,5-tetrahydro-2H-1-benzazepinyl, optionally substituted with lower alkyl, lower alkoxy, halogen, nitro or oxo, R2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl, and Z is a group selected from [Figure] and pharmaceutically acceptable salt thereof, processes for preparation thereof and pharmaceutical compositions comprising the same of antihypertensive and antithrombotic activity.

대표청구항 ▼

A compound of the formula: [Figure] wherein R1 pyridyl, thienyl, 2-oxo-1,2,3,4,-tetrahydroquinolyl or 2-oxo-1,3,4,5-tetrahydro-2H-1-benazepinyl optionally substituted with lower alkyl, lower alkoxy, halogen, or nitro; R2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)

A compound of the formula: [Figure] wherein R1 pyridyl, thienyl, 2-oxo-1,2,3,4,-tetrahydroquinolyl or 2-oxo-1,3,4,5-tetrahydro-2H-1-benazepinyl optionally substituted with lower alkyl, lower alkoxy, halogen, or nitro; R2 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl wherein ar is phenyl, xylyl, tolyl or naphthyl; R3 is hydrogen or ar(lower)alkyl wherein ar is phenyl, tolyl, xylyl or naphthyl; R5 is hydrogen, lower alkyl or carbamoyl substituted with lower alkyl or ar(lower)alkyl wherein ar is phenyl, tolyl, xylyl or naphthyl; and X is O or S, and pharmaceutically acceptable salt thereof.