3-O-acylated derivatives of (+)-cyanidan-3-ol
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/35
C07D-311/62
출원번호
US-0626823
(1984-07-02)
우선권정보
CH-0014479 (1977-11-25); CH-0002937 (1978-03-17)
발명자
/ 주소
Albert Alban (Avully CHX) Courbat Pierre (Nyon CHX) Weith Andr (Prangins CHX)
출원인 / 주소
Ciba-Geigy Corporation (Ardsley NY 02)
인용정보
피인용 횟수 :
1인용 특허 :
1
초록▼
The subject of the present invention is new O-substituted derivatives of (+)-cyanidan-3-ol corresponding to the general formula I [Figure] (I) in which R represents an optionally substituted hydrocarbon radical; an acyl radical of an organic carboxylic acid containing at least 2 carbon atoms, of a c
The subject of the present invention is new O-substituted derivatives of (+)-cyanidan-3-ol corresponding to the general formula I [Figure] (I) in which R represents an optionally substituted hydrocarbon radical; an acyl radical of an organic carboxylic acid containing at least 2 carbon atoms, of a carbonic acid or of an organic sulphonic acid; or a radical of an inorganic acid containing at least one oxygen atom, with the exception of a glucosidic radical, and the salts thereof, a process for the preparation thereof as well as their application in therapeutics and medicaments containing these new products. These compounds have a valuable activity in the prevention of hepatic necrosis and also inhibit lipoperoxidation. In addition, they are capable of acting on the fibrillation of collagen.
대표청구항▼
An O-substituted derivative of (+)-cyanidan-3-ol of the formula I [Figure] (I) in which R represents an acyl radical of an alkanecarboxylic acid containing from 4 to 18 carbon atoms which is unsubstituted or substituted by one or more hydroxy, carboxy, (C1-5 alkoxy)carbonyl, C1-5 alkanoyl, amino, mo
An O-substituted derivative of (+)-cyanidan-3-ol of the formula I [Figure] (I) in which R represents an acyl radical of an alkanecarboxylic acid containing from 4 to 18 carbon atoms which is unsubstituted or substituted by one or more hydroxy, carboxy, (C1-5 alkoxy)carbonyl, C1-5 alkanoyl, amino, mono- or di(C1-4 alkyl)amino, chloro or fluoro; cycloalkanecarboxylic acid having 3 to 6 ring carbon atoms which is unsubstituted or substituted by one, two or three, hydroxy, carboxy, C1-4 alkoxycarbonyl, amino, mono- or di-(C1-4 alkyl)amino, chloro or fluoro; cycloalkanealkanoic acid, the aliphatic chain thereof having 2 to 4 carbon atoms and the ring having 5 to 6 carbon atom; phenylalkanoic acid of which the aliphatic chain contains 1 to 4 carbon atoms and of which the phenyl nucleus is unsubstituted or substituted by one or two hydroxy, C1-C4 alkoxy, amino, carboxy, (C1-C4 alkoxy)carbonyl, C1-C4 alkanoyl, C1-C4 alkanoyloxy, chloro or fluoro; nicotinic or isonicotinic acid; (C1-C4 alkoxy)carbonyl; (C1-4 alkyl)sulphonic acid, or phenylsulphonic acid unsubstituted or substituted by one or more C1-4 alkyl, C1-4 alkoxy or halo; carbamoyl which is unsubstituted or mono- or di-substituted by C1-C4 alkyl, or phenyl groups unsubstituted or substituted by hydroxy, methoxy, ethoxy, chloro or fluoro; or a phosphoric acid which is unsubstituted or substituted by dimethyl, diethyl, or monohydroxyphenyl; and pharmaceutically acceptable salts thereof. A method for the prevention of hepatic necrosis, inhibition of lipoperoxidation and inhibition of collagen degradation which comprises administering to an animal an effective hepatic preventive, or liperoxidation or collagen degradation inhibitory, amount of a compound of claim 1.
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이 특허에 인용된 특허 (1)
Bonati Attilio (Milan ITX) Mustich Giuseppe (Milan ITX), Pharmacologically active polyphenolic substances.
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