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Process of adapting soluble bone protein for use in stimulating osteoinduction 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-063/02
  • A61K-035/32
출원번호 US-0628168 (1984-07-05)
발명자 / 주소
  • Caplan Arnold I. (1300 Oakridge Dr. Cleveland Heights OH 44121) Syftestad Glenn T. (3660 Warrensville Center Rd. #101 Shaker Heights OH 44122)
인용정보 피인용 횟수 : 78  인용 특허 : 5

초록

A method for treating implants such as biodegradable masses, xenogenic bony implants, allografts and prosthetic devices with soluble bone protein to enhance or stimulate new cartilage and/or bone formation. Substrate immobilization or surface coating techniques retard diffusion of the soluble bone p

대표청구항

A method of adapting soluble bone protein for use in osteoinduction comprising combining soluble bone protein purified to a state effective to initiate chondrogenesis with a biocompatible, biodegradable mass capable of releasing the protein in a time dependent manner for retarding diffusion of said

이 특허에 인용된 특허 (5)

  1. Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Bone graft material for osseous defects and method of making same.
  2. Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Method of inducing osseous formation by implanting bone graft material.
  3. Smestad Thomas L. (San Jose CA), Nonstress-bearing implantable bone prosthesis.
  4. Glowacki Julianne (Jamaica Plain MA) Pharriss Bruce B. (Palo Alto CA), Osteogenic composition and method.
  5. Urist Marshall R. (Pacific Palisades CA), Polymethylmethacrylate delivery system for bone morphogenetic protein.

이 특허를 인용한 특허 (78)

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  9. Pafford, John; Boyd, Lawrence M.; McKay, William F.; Ray, III, Eddie F.; Van Hoeck, James E., Bone grafts.
  10. Thorne, Kevin J., Bone growth particles and osteoinductive composition thereof.
  11. Thorne, Kevin J., Bone growth particles and osteoinductive composition thereof.
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  32. Li Shu-Tung ; McCarthy Jack A. ; Rodkey William G. ; Steadman J. Richard, Hand implant device.
  33. Morris, John W.; Knaack, David A.; Shimp, Lawrence A.; Behnam, Keyvan; Skinner, Robert P.; Betz, Randal R., Hemostatic bone graft.
  34. Yuksel, K. Umit; Walsh, Steven P.; Black, Kirby S., In situ bioprosthetic filler and method, particularly for the in situ formation of vertebral disc bioprosthetics.
  35. Yuksel, K. Umit; Walsh, Steven P.; Black, Kirby S., In situ bioprosthetic filler and methods, particularly for in situ formation of vertebral disc bioprosthetics.
  36. Shah, Gretchen Dougherty; Bae, Hyun; Lakin, Ryan C.; Hawkins, Nathaniel E., Intervertebral implant and associated method.
  37. Lakin, Ryan Cameron; Bailey, Kirk J.; Blumers, John M., Intervertebral implantation apparatus.
  38. James E. Van Hoeck ; Troy McDonald ; Bradley J. Coates ; Regis W. Haid, Jr. ; Stephen E. Heim ; Kevin Foley ; Eugene C. Eckstein, Intervertebral spacers.
  39. Van Hoeck, James E.; McDonald, Troy; Coates, Bradley J.; Haid, Jr., Regis W.; Heim, Stephen E.; Foley, Kevin; Eckstein, Eugene C., Intervertebral spacers.
  40. Van Hoeck,James E.; McDonald,Troy; Coates,Bradley J.; Haid, Jr.,Regis W.; Heim,Stephen E.; Foley,Kevin; Eckstein,Eugene C., Intervertebral spacers.
  41. Prockop Darwin J. ; Pereira Ruth F. ; Leeper Dennis B. ; O'Hara Michael D., Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects.
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  67. Cima Linda G. ; Cima Michael J., Preparation of medical devices by solid free-form fabrication methods.
  68. Ringeisen Timothy ; Brekke John H., Process and device for treating and healing a tissue deficiency.
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  71. Thorne, Kevin; Akella, Rama, Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue.
  72. Cima, Linda G.; Cima, Michael J., Tissue regeneration matrices by solid free-form fabrication techniques.
  73. Lewandrowski, Kai-Uwe; Bondre, Shrikar; Trantolo, Debra J.; Cattaneo, Maurice V.; Gresser, Joseph D.; Wise, Donald L., Tissue transplant coated with biocompatible biodegradable polymer.
  74. Woo,Yi Ren; Pandit,Abhay S., Valved prosthesis with porous substrate.
  75. Vacanti Joseph P. ; Cima Linda G. ; Cima Michael J., Vascularized tissue regeneration matrices formed by solid free form fabrication techniques.
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