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Acidity-sensitive spacer molecule to control the release of pharmaceuticals from molecular carriers 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/44
출원번호 US-0277633 (1981-06-26)
발명자 / 주소
  • Shen Wei C. (145 Richdale Rd. Needham MA 02194) Ryser Hugues J. (503 Annursnac Hill Rd. Concord MA 01742)
인용정보 피인용 횟수 : 35  인용 특허 : 16

초록 ▼

A method for controlling the release of drugs or other passenger moleculars from carrier conjugates, and a class of conjugates that releases drugs when ingested by a cell or subjected to acidic conditions, are disclosed. These conjugates contain a passenger molecule which is attached to a spacer mol

대표청구항 ▼

A method of employing a first molecule and a second molecule to transport a third molecule through a first region to a second region that is more acidic than said first region, and to release said third molecule from said first and second molecules in said second region, comprising the following ste

이 특허에 인용된 특허 (16)

  1. Carrico Robert J. (Elkhart IN) Ngo That T. (Elkhart IN), b 상세보기
  • Mune Isao (Osaka JPX) Ushiyama Keiichi (Osaka JPX) Saito Kenitiro (Osaka JPX) Moroishi Yutaka (Osaka JPX) Nakao Tadaichi (Osaka JPX), Antibacterial and antifungal material.
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  • Likhite Vilas V. (317 Marlborough St. Boston MA 02116), Antigens comprising immunostimulant adjuvants and their use in immunotherapy.
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  • Heller Jorge (Palo Alto CA), Controlled drug release composition.
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  • Wright John J. (Cedar Grove NJ), Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and.
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  • Zweig Jack (145 Vaneck Dr. New Rochelle NY 10804) McLaughlin William (3901 Albemarle St. ; NW. Washington DC 20016) Herz Matthew L. (20 Swanson Rd. Framingham MA 01701), Drug activation by radiation.
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  • Carrico Robert J. (Elkhart IN) Ngo That T. (Elkhart IN), Flavin adenine dinucleotide-labeled protein and polypeptide conjugates.
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  • Lemieux Raymond U. (Edmonton CAX) Bundle David R. (Ottawa CAX) Baker Donald A. (Edmonton CAX), Glycoside-ether-ester compounds.
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  • Sela ; Michael ; Arnon ; Ruth ; Maron ; Ruth ; Hurvitz ; Esther, Immunologic chemotherapeutic agents comprising antigen binding dimers covalently bound to drugs.
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  • Rowland George Ferdinand (Gerrards Cross EN), Immunological materials.
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  • Goldstein Leon (Rehovot ILX) Freeman Amihay (Rishon Lezion ILX) Sokolovsky Mordechai (Tel-Aviv ILX), Isonitrile derivatives of macromolecules containing hydroxyl groups.
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  • De Barbieri Augusto (Milan ITX), N-Acyl derivatives of glucosamine having antitumor chemotherapeutic acitivity.
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  • Levin Yehuda (Tel Aviv ILX) Sela Ben-Ami (Rehovot ILX), Novel derivatives of daunomycin.
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  • Ross Walter C. J. (Sunbury on Thames GB2), Peptide macromolecular complexes.
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  • Wise Donald L. (Belmont MA), Sustained release of pharmaceuticals from polyester matrices.
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  • Buckler Robert T. (Edwardsburg MI) Burd John F. (Elkhart IN) Wong Raphael C. (Elkhart IN), Valproic acid immunogen conjugates and antibodies thereto.
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    • 이 특허를 인용한 특허 (35)

    1. Barton Russell L. (Indianapolis IN), Antibody-drug conjugates.
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    2. Davis, Mark E.; Alabi, Akinleye, Carrier nanoparticles and related compositions, methods and systems.
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    3. Davis, Mark E.; Alabi, Akinleye, Carrier nanoparticles and related compositions, methods and systems.
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    4. Davis, Mark E.; Alabi, Akinleye, Carrier nanoparticles and related compositions, methods and systems.
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    5. Davis, Mark E.; Alabi, Akinleye, Carrier nanoparticles and related compositions, methods and systems.
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    6. Davis, Mark E.; Alabi, Akinleye, Carrier nanoparticles and related compositions, methods and systems.
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    7. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into epithelial tissues.
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    8. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into epithelial tissues.
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    9. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into epithelial tissues.
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    10. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into epithelial tissues.
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    11. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, Leo P.; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into ocular tissues.
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    12. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for enhancing drug delivery across and into ocular tissues.
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    13. Rothbard,Jonathan B.; Wender,Paul A.; McGrane,P. Leo; Sista,Lalitha V. S.; Kirschberg,Thorsten A., Compositions and methods for enhancing drug delivery across and into ocular tissues.
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    14. Bond, Vincent C.; Lillard, Jr., James W.; Huang, Ming Bo, Compositions and methods for treating diseases by inhibiting exosome release.
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    15. Rothbard, Jonathan B.; Wender, Paul A.; McGrane, P. Leo; Sista, Lalitha V. S.; Kirschberg, Thorsten A., Compositions and methods for treating inflammatory diseases of the skin.
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    16. De Souza Russo,Elisa Mannochio; Torres Russo,Valter Freire, Compounds in the form of homodimeric or heterodimeric pro-drugs; process for obtaining these pro-drugs and their acceptable pharmaceutical salts and use of compounds in the treatment of phosphodieste.
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    17. Green, Howard; Compton, Bruce; Corey, George; Djian, Philippe, Conjugates of agents and transglutaminase substrate linking molecules.
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    18. Santi, Daniel V.; Hearn, Brian, Conjugates with reduced adverse systemic effects.
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    19. Johnson David A. (Carmel IN) Laguzza Bennett C. (Indianapolis IN) Scott William L. (Indianapolis IN), Cytotoxic antibody conjugates of hydrazide derivatized methotrexate analogs via simple organic linkers.
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    20. Cullinan George J. (Trafalgar IN) Laguzza Bennett C. (Indianapolis IN) Scott William L. (Indianapolis IN), Intermediates for antibody-vinca drug conjugates.
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    21. Green, Howard; Compton, Bruce J.; Corey, George D.; Djian, Philippe, Linkage of agents to body tissue using microparticles and transglutaminase.
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    22. Jonathan B. Rothbard ; Paul A. Wender, Method and composition for enhancing transport across biological membranes.
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    23. Rothbard Jonathan B. ; Wender Paul A., Method and composition for enhancing transport across biological membranes.
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    24. Wiley, Devin; Clark, Andrew; Davis, Mark E., Method of delivering therapeutics and imaging agents to the brain by nanoparticles that cross the blood brain barrier.
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    25. McChesney, James D.; Chander, Madhavi C.; Siahaan, Teruna J.; Xu, Christine R.; Ainsworth, Sterling K., Molecular conjugates for use in treatment of cancer.
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    26. McChesney,James D.; Chander,Madhavi C.; Siahaan,Teruna J.; Xu,Christine R.; Ainsworth,Sterling K., Molecular conjugates for use in treatment of cancer.
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    27. Renslo, Adam; Mahajan, Sumit, Prodrug compositions and methods for using the same in treating cancer and malaria.
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    28. Shen, Wei-Chiang; Heiati, Hashem, Reversible aqueous pH sensitive lipidizing reagents, compositions and methods of use.
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    29. Davis, Mark E.; Han, Han, Targeted nanoparticles.
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    30. Friden Phillip M., Transferrin receptor reactive chimeric antibodies.
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    31. Friden Phillip M., Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates.
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    32. Friden Phillip M., Transferrin receptor specific antibody-neuropharmaceutical or diagnostic agent conjugates.
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    33. Friden Phillip M. ; Starzyk Ruth M. ; Morrison Sherie L. ; Park Eun-Chung ; McGrath John P., Transferrin receptor specific ligand-neuropharmaceutical agent fusion proteins.
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    34. Bredesen, Dale E.; Galvan, Veronica, Transgenic mouse whose genome comprises an APP having a mutation at amino acid 664.
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    35. Hellstrom Karl E. (Seattle WA) Hellstrom Ingegerd E. (Seattle WA) Lavie Efraim (Seattle WA), pH-sensitive immunoconjugates and methods for their use in tumor therapy.
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