초록 ▼

An in vivo assay for quantifying the mineral content of bone comprises placing living bone into or adjacent to the coil of a nuclear magnetic resonance (NMR) spectrometer, recording a 31P NMR spectrum while the bone is stationary, and comparing the spectrum obtained with the NMR spectrum of a refere

An in vivo assay for quantifying the mineral content of bone comprises placing living bone into or adjacent to the coil of a nuclear magnetic resonance (NMR) spectrometer, recording a 31P NMR spectrum while the bone is stationary, and comparing the spectrum obtained with the NMR spectrum of a reference standard containing a known concentration of a reference compound. The assay can be used to diagnose and determine the efficacy of treatment of osteodystrophy if used in conjunction with radiographic densitometry to estimate the calcium content of the bone.

대표청구항 ▼

A noninvasive in vivo assay of the mineral content of a bone in an animal comprises: (a) placing the part of the body of the animal containing said bone to be analyzed within the operational range of a receiver coil of a NMR spectrometer; (b) recording a 31P NMR spectrum of the bone while keeping th

A noninvasive in vivo assay of the mineral content of a bone in an animal comprises: (a) placing the part of the body of the animal containing said bone to be analyzed within the operational range of a receiver coil of a NMR spectrometer; (b) recording a 31P NMR spectrum of the bone while keeping the bone stationary; and (c) then comparing the quantitative spectral results obtained in step (b) to the spectral results obtained with a reference standard containing a known concentration and quantity of a reference compound which responds to 31P NMR spectroscopy in a manner similar to that of bone mineral but which does not overlap the resonance of bone material.