초록 ▼

A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permea

A medical device for the transdermal delivery of highly ionized, fat insoluble drugs comprises an aqueous drug reservoir having a physiological pH, said reservoir preferably being a gel maintained in an impermeable receptacle by a highly permeable support member disposed between the gel and a permeable contact adhesive. A permeation enhancer reservoir delivers a permeation enhancer to the skin through the aqueous reservoir and through a permeation enhancer release rate controlling membrane which is permeable to the permeation enhancer and impermeable to the drug and water. In a preferred embodiment the permeation enhancer release rate controlling membrane forms at least a portion of said receptacle.

대표청구항 ▼

A medical device for the transdermal delivery of a highly ionized, fat insoluble drug comprising, in combination: a. aqueous drug reservoir means comprising at at least 50% water having said drug dissolved therein; b. receptacle means containing said reservoir means, said receptacle means being subs

A medical device for the transdermal delivery of a highly ionized, fat insoluble drug comprising, in combination: a. aqueous drug reservoir means comprising at at least 50% water having said drug dissolved therein; b. receptacle means containing said reservoir means, said receptacle means being substantially impermeable to the contents of said reservoir means; c. highly permeable reservoir retaining means disposed over the the skin proximal surface of said aqueous reservoir means; d. permeation enhancer delivery means for delivering a permeation enhancer to the skin through said aqueous reservoir means, said permeation enhancer delivery means being disposed in permeation enhancer transferring relationship to said aqueous reservoir means and comprising: (i) a source of permeation enhancer, and (ii) permeation enhancer release rate controlling means disposed between said source of permeation enhancer and said aqueous reservoir means, said permeation enhancer release rate controlling means comprising a material permeable to said permeation enhancer and substantially impermeable to water and said drug; and e. means for maintaining said medical device in permeation enhancer and drug transmitting relationship to the skin.