초록 ▼

Apparatus and method for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a pattern formed by a spatial array of microscopic dimensions of antiligand material, ligand material interacting with the antiligand material to produce a binding reaction be

Apparatus and method for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a pattern formed by a spatial array of microscopic dimensions of antiligand material, ligand material interacting with the antiligand material to produce a binding reaction between the ligand and the antiligand in the pattern, a source of optical radiation including energy at at least one wavelength directed to the pattern at a particular incidence angle to produce scattering of the energy from the pattern in accordance with the binding reaction and with a strong scattering intensity at one or more Bragg scattering angles, and at least one optical detector located relative to the pattern and aligned with a Bragg scattering angle to detect the strong scattering intensity at the Bragg scattering angle to produce a signal representative of the binding reaction.

대표청구항 ▼

An apparatus for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a predetermined pattern formed by a spatial array having a plurality of elements of microscopic dimensions of antiligand material, ligand material interacting with the spatial array o

An apparatus for providing an optical detection of a binding reaction between a ligand and an antiligand, including, a predetermined pattern formed by a spatial array having a plurality of elements of microscopic dimensions of antiligand material, ligand material interacting with the spatial array of antiligand material to produce a binding reaction between the ligand and the antiligand in the pattern, a source of optical radiation directed toward the pattern to illuminate the plurality of elements of the spatial array to produce an optical interference pattern in accordance with the modulation of the optical properties of the predetermined antiligand pattern due to the binding reaction, and one or more optical detectors to detect the strong scattering intensity at one or more angles to produce a signal representative of the binding reaction.