초록 ▼

An absorbable biologically compatible putty-like composition is used as a matrix from which immunologically or pharmacologically active agents, such as antibiotics, can be introduced into the body to provide a slow sustained release of the agent over an extended period of time. A preferred matrix co

An absorbable biologically compatible putty-like composition is used as a matrix from which immunologically or pharmacologically active agents, such as antibiotics, can be introduced into the body to provide a slow sustained release of the agent over an extended period of time. A preferred matrix comprises a mixture of calcium stearate, dextran and castor oil.

대표청구항 ▼

In a pharmaceutical depot composition for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time at reasonably effective and predictable levels, which comprises a combination of (a) from 0.25% to 50% by weight of the compositi

In a pharmaceutical depot composition for administration of at least one pharmacologically or immunologically active agent released slowly over an extended period of time at reasonably effective and predictable levels, which comprises a combination of (a) from 0.25% to 50% by weight of the composition of a pharmacologically or immunologically active agent in an effective depot amount greater than the single dose amount, and (b) a matrix which is minimally reactive towards body tissue and which is absorbable in the body over an extended period of time without adverse body reaction; the improvement comprising employing as said matrix an absorbable composition having a putty-like consistency at room and body temperatures, said matrix being completely free of fibrous materials, said matrix comprising between about 35% and 60% by weight of calcium stearate, between about 10% and about 35% by weight of dextran, the remainder of said matrix comprising castor oil.