초록 ▼

A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of

A dispenser is disclosed for delivering a beneficial agent to an environment of use. The dispenser comprises a semipermeable wall surrounding a compartment containing a heat responsive composition, and an expandable composition. A passageway in the wall connects the compartment with the exterior of the dispenser.

대표청구항 ▼

A dispenser for delivering a beneficial drug to a biological environment of use, wherein the dispenser comprises: (a) a wall comprising in at least a part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of a beneficial drug, which wall surro

A dispenser for delivering a beneficial drug to a biological environment of use, wherein the dispenser comprises: (a) a wall comprising in at least a part a semipermeable composition permeable to the passage of fluid and substantially impermeable to the passage of a beneficial drug, which wall surrounds; (b) a pharmaceutically acceptable single-piece capsule; (c) means in the capsule for absorbing heat from the biological environment for forming a dispensable composition, which means exhibits storable properties up to 32°C. and becomes at least one of fluid, semisolid and viscous at a temperature of 32°C. to 40°C. thereby providing a dispensable composition; (d) a beneficial drug housed in the means for absorbing heat from the biological environment, said drug producing at least one of a local and systemic effect when the dispenser is in operation in the biological environment; (e) means in the capsule for urging the means for absorbing heat comprising the beneficial drug from the dispenser, said urging means at least one of a member selected from the group consisting of an expandable acrylate, pyrrolidone, anionic hydrogel, cationic hydrogel, polyelectrolyte, cellulosic, polysaccharide, carboxypolymer, acrylamide, polyalkylene oxide, starch, and vinyl lactam; and, (f) at least one orifice in the dispenser for delivering the beneficial drug composition from the dispenser.