DeVries Vern G. (Ridgewood NJ) Upeslacis Janis (Pomona NY)
출원인 / 주소
American Cyanamid Company (Stamford CT 02)
인용정보
피인용 횟수 :
5인용 특허 :
0
초록
This invention is concerned with novel 4-[(trialkylsilyl)alkylamino]phenyl compounds and their use as antiatherosclerotic agents.
대표청구항▼
A compound of the formula: [Figure] wherein, A is selected from the group consisting of a saturated, straight-chain alkylene moiety of 3-20 carbon atoms; a saturated, branched alkylene moiety of 3-20 carbon atoms; an unsaturated, straight-chain alkylene moiety of 3-20 carbon atoms; an unsaturated, a
A compound of the formula: [Figure] wherein, A is selected from the group consisting of a saturated, straight-chain alkylene moiety of 3-20 carbon atoms; a saturated, branched alkylene moiety of 3-20 carbon atoms; an unsaturated, straight-chain alkylene moiety of 3-20 carbon atoms; an unsaturated, and branched alkylene moiety of 3-20 carbon atoms; R1, R2, and R3 are the same or different and are independently selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C4-C7 cycloalkyl, and C4-C20 cycloalkylalkyl; R is selected from the group consisting of hydrogen, methyl, carboxymethyl, acetyl, succinyl, and sodium sulfo-methyl; and (a) J is [Figure] Z being selected from the group consisting of hydrogen, C1-C4 alkyl, hydroxy, C1-C4 alkoxy, 2,3-dihydroxypropyl, alkyloxy, 2,3-epoxypropyl, benzoyloxy, phenoxy, 3-pyridyloxy, pyridylmethoxy, tetrahydropyranyloxy, amino, (C1-C4 alkyl)amino, di(C1-C4 alkyl)amino, allylamino, propargylamino, 2-sulfoethylamino, (C1-C4-alkanoyl)amino, benzoylamino, (C1-C4-alkanesulfonyl)amino, benzenesulfonylamino, toluenesulfonylamino; (b) J is selected from the group consisting of (carboxy)-C1-C4-alkyl, (carboxy)-C2-C4-alkenyl, (carboxy)-C2-C4-alkylnyl, (C1-C4-carboalkoxy)-C1-C4-alkyl, (C1-C4-carboalkoxy)-C2-C4-alkenyl, (C1-C4-carboalkoxy)-C2-C4-alkynyl; and the pharmaceutically acceptable, non-toxic, acid-addition and cationic salts thereof.
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이 특허를 인용한 특허 (5)
Edwards Michael L. ; Vaal Mark J. ; Parker Roger A. ; Matt James E. ; Chen Kim S. ; Yates Mark T., 2,6-di-t-butyl-4-[(dimethyl-4-methoxyphenylsilyl)-methyl-oxy]phenol and 2,6-di-t-butyl-4-[(dimethyl-2-methoxy-phenylsilyl)methyloxy]phenol.
Mao Simon J. T. (Miaoli TWX) Yates Mark T. (Cinncinati OH) Parker Roger A. (Cinncinati OH), Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols.
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