A resorptive sheet material for closing and healing wounds substantially consists of a glycoprotein matrix containing substances which cause and, respectively, are conductive to the coagulation of blood including fibrinogen and thrombin. The sheet material is dry and of multi-layered structure, wher
A resorptive sheet material for closing and healing wounds substantially consists of a glycoprotein matrix containing substances which cause and, respectively, are conductive to the coagulation of blood including fibrinogen and thrombin. The sheet material is dry and of multi-layered structure, wherein at least one layer is free from thrombin and contains in the glycoprotein matrix thereof the fibrinogen in a substantially homogeneously distributed form, and at least one further layer is free from fibrinogen and contains in the glycoprotein matrix thereof the thrombin in a substantially homogenenously distributed form. The glycoproteins coming into consideration, above all, are non-linked fibrin, fibrin fission products, collagen, globulin, myoglobulin, casein and/or albumin. Preferably, at least one of the layers, especially one or both outer layer(s), contains fibroblast cells present in dry state and/or agents conducive to the growth of the fibroblasts and their spreading-in, especially chondroitin sulphate. For the production, fibrinogen is added to a thrombin-free, predominantly aqueous solution and/or suspension of the glycoprotein and said solution and/or suspension is processed to form a sheet-material layer, and onto the full surface of this layer at least one further layer is applied which, in its turn, has been obtained from a further, fibrinogen-free and thrombin-containing solution and/or suspension of the same or of another glycoprotein. In particular, a solution and/or suspension of one composition is applied onto an inert surface, where it is subjected to deep-freezing, and onto the resultant ice-layer surface, when still in the deep-frozen state, a solution and/or suspension of different composition is applied and subjected to deep-freezing, and, finally, all layers are jointly subjected to lyophilization.
대표청구항▼
A method of making a resorptive sheet material for closing and healing wounds, consisting essentially of a glycoprotein matrix containing substances which cause and, respectively, are conducive to the coagulation of blood, including fibrinogen and thrombin, wherein the sheet material is dry and of m
A method of making a resorptive sheet material for closing and healing wounds, consisting essentially of a glycoprotein matrix containing substances which cause and, respectively, are conducive to the coagulation of blood, including fibrinogen and thrombin, wherein the sheet material is dry and of multi-layered structure; at least one layer is free from thrombin and contains in the glycoprotein matrix thereof, the fibrinogen in a substantially homogeneously distributed form; and at least one further layer is free from fibrinogen and contains in the glycoprotein matrix thereof the thrombin in a substantially homogeneously distributed form; which process comprises adding fibrinogen to a thrombin-free, predominantly aqueous solution or suspension of the glycoprotein and processing said solution or suspension to form a sheet material layer; and applying onto the full surface of this layer at least one further layer which, in its turn, has been obtained from a further layer, fibrinogen-free and thrombin-containing solution or suspension of the same or of another glycoprotein.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (4)
Stemberger Axel (Neubiberg DEX), Collagenous dressing.
Tipton Arthur J. (Birmingham AL) Fujita Shawn M. (Amsterdam NLX) Dunn Richard L. (Fort Collins CO), Biodegradable film dressing and method for its formation.
Cornwell, Kevin G.; Pins, George D.; Billiar, Kristen, Collagen and fibrin microthreads in a discrete thread model of in vitro ACL scaffold regeneration.
Yves Delmotte BE; Arnold Bilstad ; David Amrani ; James DiOrio ; Atif M. Yardimci ; David W. Pennington ; James S. Slepicka ; Cristina Stadler, Fibrin delivery device and method for forming fibrin on a surface.
Ranney David F., In vivo agents comprising cationic drugs, peptides and metal chelators with acidic saccharides and glycosaminoglycans, giving improved site-selective localization, uptake mechanism, sensitivity and k.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.