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Water soluble drug complex and method for production of same

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-031/70
  • A61K-031/685
  • A61K-031/545
출원번호 US-0716436 (1985-03-27)
우선권정보 JP-0063994 (1984-03-31)
발명자 / 주소
  • Fukushima Tsunekazu (Hyogo JPX) Emoto Hiroshi (Osaka JPX) Kagitani Yoshio (Nara JPX) Yokoyama Kazumasa (Osaka JPX) Nishida Masayuki (Osaka JPX) Suyama Tadakazu (Kyoto JPX)
출원인 / 주소
  • Green Cross Corporation (Osaka JPX 03)
인용정보 피인용 횟수 : 33  인용 특허 : 7

초록

The invention provides a method of producing a water-soluble complex comprising a water-insoluble drug and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a phospholipid in an organic solvent, (2) removing the solvent to leave behind a drug-containing phospholipid f

대표청구항

A method of producing a water-soluble complex comprising a water-insoluble drug which is a pharmacologically active compound having a molecular weight not over 1,000 and a phospholipid, comprising the steps of (1) dissolving a water-insoluble drug and a phospholipid in an organic solvent in a ratio

이 특허에 인용된 특허 (7)

  1. Yamada Morio (Yokohama JPX) Kimura Yoshihiko (Yokohama JPX), Apparatus for flowing and filling liquified inert gas.
  2. Okada Taiji (26-41 ; Motoujinamachi ; Hiroshima JPX), Carcinostatic composition containing 3-N-o-toluyl-5-fluorouracil producing the same.
  3. Geho, Walter B., Lipid membrane drug delivery.
  4. Sache Edgar (Bures-sur-Yvette FRX) Bertrand Henri (Chatillon-sur-Bagneux FRX), Liposomes containing heparin and a process for obtaining them.
  5. Schmidt Dieter (Basel CHX), Pharmaceutical compositions for parenteral or local administration.
  6. Schrank Jrg (Riehen CHX) Steffen Hans (Arisdorf CHX), Pharmaceutical preparations.
  7. Kodama Yutaka (Toyama JPX) Oyama Kaoru (Toyama JPX) Shimizu Ryusaku (Nanao JPX) Nakabayashi Masao (Namekawa JPX) Nakashima Yoshifumi (Himi JPX) Sano Takashi (Toyama JPX) Shibata Masaaki (Toyama JPX) , Treatment of cancer with carcinostatic and immunostimulating agent containing lysophospholipid and phospholipid.

이 특허를 인용한 특허 (33)

  1. Parikh, Indu; Moussa, Iskandar; Carrier, Alain, Anticancer compositions.
  2. Dickinson Jeffrey,GBX, Aqueous drink composition comprising ibuprofen.
  3. Vachon, Michael; Awadesh, Mishra K.; Snow, Robert A.; Guivarc'H, Pol-Henri, Coated tablets.
  4. Vachon, Michael; Awadhesh, Mishra K.; Snow, Robert A.; Guivarc'h, Pol-Henri, Coated tablets.
  5. Lichtenberger, Lenard M., Compositions comprising lecithin oils and NSAIDs for protecting the gastrointestinal tract and providing enhanced therapeutic activity.
  6. Lichtenberger, Lenard M., Compositions comprising lecithin oils and NSAIDs for protecting the gastrointestinal tract and providing enhanced therapeutic activity.
  7. Lichtenberger, Lenard M., Compositions comprising lecithin oils and NSAIDs for protecting the gastrointestinal tract and providing enhanced therapeutic activity.
  8. Parikh,Indu, Fenofibrate microparticles.
  9. Mishra,Awadhesh K.; Pace,Gary W.; Vachon,Michael G, Injectable aqueous dispersions of propofol.
  10. Mishra,Awadhesh K.; Pace,Gary W.; Vachon,Michael G., Injectable aqueous dispersions of propofol.
  11. Henriksen, Inge B; Mishra, Awadesh K.; Pace, Gary W.; Johnston, Keith P.; Mawson, Simon, Insoluble drug delivery.
  12. Henriksen, Inge B; Mishra, Awadesh K.; Pace, Gary W.; Johnston, Keith P.; Mawson, Simon, Insoluble drug delivery.
  13. Lenk Robert P. ; Mehta Reeta ; Lopez-Berestein Gabriel, Liposomal-polyene preliposomal powder and method for its preparation.
  14. Link Robert P. ; Mehta Reeta ; Lopez-Berestein Gabriel, Liposomal-polyene preliposomal powder and method for its preparation.
  15. Betageri, Guru V.; Yatvin, Milton B., Liposome drug delivery.
  16. Betageri,Guru V.; Yatvin,Milton B., Liposome drug delivery.
  17. Mayhew Eric (South Wales NY) Ehrke M. Jane (Lancaster NY) Mace Kenneth (Buffalo NY) Szoka Francis (San Francisco CA) Olson Fred C. (Helena MT), Liposome drug delivery method and composition.
  18. Yatvin, Milton, Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds.
  19. Yatvin,Milton, Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds.
  20. Lichtenberger, Lenard M., Methods of making compositions comprising lecithin oils and NSAIDS for protecting the gastrointestinal tract and providing enhanced therapeutic activity.
  21. Andrew S. Janoff ; Thomas D. Madden CA; Pieter R. Cullis CA; John J. Kearns ; Anthony G. Durning, Methods of preparing low-toxicity drug-lipid complexes.
  22. Lichtenberger, Lenard M., Methods of treating inflammation with compositions comprising lecithin oils and NSAIDS for protecting the gastrointestinal tract and providing enhanced therapeutic activity.
  23. Baurain Roger (Wezembeek BEX) Trouet Andre B. L. (Winksele BEX), Microcrystals comprising an active substance having an affinity for phospholipids, and at least one phospholipid, proces.
  24. Parikh, Indu; Selvaraj, Ulagaraj, Microparticles of water-insoluble substances.
  25. Verhoff, Frank; Pace, Gary W.; Snow, Robert A.; Millar, Fay, Milled particles.
  26. Marathi, Upendra K.; Childress, Susann Edler; Gammill, Shaun L.; Strozier, Robert W., PH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same.
  27. Mehta Reeta (Houston TX) Lopez-Berestein Gabriel (Houston TX), Polyene microlide pre-liposomal powders.
  28. Huang Anthony H. (Sunnyvale CA) Krishnan Satya (Mountain View CA), Preparation of injectable doxorubicin/liposome suspension.
  29. Mishra, Awadhesh K., Thermoprotected compositions and process for terminal steam sterilization of microparticle preparations.
  30. Pace, Gary W.; Mishra, Awadesh K., Water-insoluble drug particle process.
  31. Marathi, Upendra K.; Childress, Susann Edler; Gammill, Shaun L.; Strozier, Robert W., pH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same.
  32. Marathi, Upendra K.; Childress, Susann Edler; Gammill, Shaun L.; Strozier, Robert W., pH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same.
  33. Marathi, Upendra K.; Childress, Susann Edler; Gammill, Shaun L.; Strozier, Robert W., pH dependent carriers for targeted release of pharmaceuticals along the gastrointestinal tract, compositions therefrom, and making and using same.
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