초록 ▼

The present invention discloses a group of calcium chelating compounds which have a descreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca2+chelating parent compound having the octacoordinate chelating

The present invention discloses a group of calcium chelating compounds which have a descreased affinity for calcium following illumination. These new compounds contain a photolabile nitrobenzyl derivative coupled to a tetracarboxylate Ca2+chelating parent compound having the octacoordinate chelating groups characteristic of EGTA or BAPTA. In a first form, the new compounds are comprised of a BAPTA-like chelator coupled to a single 2-nitrobenzyl derivative, which in turn is a photochemical precursor of a 2-nitrosobenzophenone. In a second form, the new compounds are comprised of a BAPTA-like chelator coupled to two 2-nitrobenzyl derivatives, themselves photochemical prcursors of the related 2-nitrosobenzophenones. The present invention also discloses a novel method for preparing 1-hydroxy- or 1-alkoxy-1-(2-nitroaryl)-1-aryl methanes. Methanes of this type are critical to the preparation of, or actually constitute, the photolabile Ca2+chelating compounds disclosed and claimed herein.

대표청구항 ▼

A chemical compound having the general formula: [Figure] and the pharmaceutically acceptable non-toxic salts and esters thereof wherein: A is －NO2 or －H; R3, R4 and R5 are independently －H, OH, NR6R7, or alkoxy, or R3 and R4 together are －OCH2O－or －OCH2CH2O－and R5 is －H, OH, NR6R7, or alkoxy, or R4

A chemical compound having the general formula: [Figure] and the pharmaceutically acceptable non-toxic salts and esters thereof wherein: A is －NO2 or －H; R3, R4 and R5 are independently －H, OH, NR6R7, or alkoxy, or R3 and R4 together are －OCH2O－or －OCH2CH2O－and R5 is －H, OH, NR6R7, or alkoxy, or R4 and R5 together are －OCH2O－or －OCH2CH2O－and R3 is －H, OH, NR6R7, or alkoxy; X is selected from the group comprised of －OH, alkoxy, －Cl, －Br, －NR6R7, －OCOCH3, －OCOCF3, －OCOCH2NH2, －OPO3H, and －OSO2CH3; R6 and R7 are independently －H, methyl or ethyl; D is O, N, NH, or N alkyl; Q is a double bond when D is N and a single bond otherwise; R8 is H and R9 is H or R8 and R9, togehter with heteroatom D, the carbon adjacent to R8, and the phenyl ring adjacent to R9, form quinoline ring system (D〓N, Q〓double bond); and W is －H, －OH, or NHR6, or alkoxy.