초록

Alpha-L-Aspartyl-D-heteroaromatic-substituted glycine esters and amides are disclosed to be useful as high intensity sweeteners. These compounds can be used to sweeten a variety of foods, beverages and other oral products.

대표청구항 ▼

A compound of the formula: [Figure] and nontoxic salts thereof; wherein the said ester or amide is the L,D stereochemical isomer; wherein X1 is O or NH; and wherein R is a heteroaromatic group having a 5 or 6 member heteroaromatic ring selected from the group consisting of furyl, thienyl, pyrryl, ox

A compound of the formula: [Figure] and nontoxic salts thereof; wherein the said ester or amide is the L,D stereochemical isomer; wherein X1 is O or NH; and wherein R is a heteroaromatic group having a 5 or 6 member heteroaromatic ring selected from the group consisting of furyl, thienyl, pyrryl, oxazolyl, thiazolyl, imidazolyl, isoxazolyl, isothiazolyl, pyrazolyl, oxadiazolyl, thiadiazolyl, triazolyl, tetrazolyl, pyridyl, pyrazinyl, pyrimidinyl, pyridazinyl and triazinyl; and wherein R′is selected from the group consisting of hydrocarbyl radicals having formulas (a) (b) (c) (d) (e) (f) and (g): [Figure] (a) [Figure] (b) [Figure] (c) [Figure] (d) [Figure] (e) [Figure] (f) [Figure] (g) wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12 and R13 are H, or C1-C4 alkyl, hydroxyalkyl or alkoxy; X2 is CH2, O, S, SO, SO2, C〓O, CR14OH, NR14 [Figure] wherein R14 is H or C1-C2 alkyl or hydroxyalkyl; provided that when R1 is a hydrocarbyl radical of formal (e), (f) or (g), R10, R11, R12 and R13 are each H when X2 is other than CH2 or O; m is 0, 1, 2, 3 or 4; n is 0, 1, 2, 3, or 4; p and q are 0, 1, 2 or 3 and the sum of p+q is not greater than 3; x is 1, 2 or 3; y and z are 0, 1 or 2 and the sum of y+z is not greater than 2.