초록 ▼

A transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such t

A transdermal therapeutic system using a subsaturated matrix is provided having improved approved release characteristics. Reinforcing means preferably in the form of a fabric are embedded in the upper surface of the subsaturated matrix. At least a portion of the reinforcing means is selected such that the active agent to be delivered to the skin has a solubility, Cr therein which is lower than the initial solubility Co of the agent in the matrix. In addition, the relationship between the diffusion coefficients of the agent in the matrix Dm and the portion of reinforcing means Dr and the solubilities is given by the relationship: DrㆍCrmㆍCo. In operation the agent dissolved in the reinforcing means acts as a secondary reservoir improving the release characteristics of the system. Specific embodiments of the invention are particularly adapted for scrotal and labial delivery of drugs such as testosterone and progesterone.

대표청구항 ▼

A subsaturated transdermal therapeutic system having improved release characteristics comprising, in combination: (a) a matrix containing an active agent to be dispensed therefrom at an initial concentration, Co, no greater than the saturation concentration of the agent in the matrix; (b) reinforcin

A subsaturated transdermal therapeutic system having improved release characteristics comprising, in combination: (a) a matrix containing an active agent to be dispensed therefrom at an initial concentration, Co, no greater than the saturation concentration of the agent in the matrix; (b) reinforcing means within the matrix, at least a portion of said reinforcing means being a solvent for said agent, said portion of said reinforcing means having a solubility for said agent, Cr, less than the initial concentration of the agent in the matrix and wherein the diffusion coefficient of said agent in said matrix is Dm, the diffusion coefficient of said agent in the solvent portion of said reinforcing means is Dr and the values of Dm, Dr, Co and Cr are selected such that: DrㆍCrmㆍCo.