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Prolonged release microcapsules and their production 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/52
  • B01J-013/02
출원번호 US-0940614 (1986-12-11)
우선권정보 JP-0207760 (1983-11-04)
발명자 / 주소
  • Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX)
출원인 / 주소
  • Takeda Chemical Industries, Ltd. (Osaka JPX 03)
인용정보 피인용 횟수 : 86  인용 특허 : 4

초록 ▼

A microcapsule produced by preparing a water-in-oil emulsion comprising an inner aqueous layer containing said water-soluble drug and a drug retaining substance therefor and an oil layer containing a polymer substance, then thickening or solidifying said inner aqueous layer to a viscosity of not low

대표청구항

A prolonged release microcapsule having an average diameter of about 0.5 to 400 m5000 centipoises and finally admixing the resulting emulsion with third aqueous layer to give a water/oil/water ternary layer emulsion and then desorbing the solvent in the oil layer.

이 특허에 인용된 특허 (4)

  1. Jaffe Howard (Gaithersburg MD), Microencapsulation process.
    상세보기
  2. Nestor John J. (San Jose CA) Jones Gordon H. (Cupertino CA) Vickery Brian H. (Cupertino CA), Nonapeptide and decapeptide derivatives of luteinizing hormone releasing hormone.
    상세보기
  3. Nevin Robert S. (Indianapolis IN), Polymerization process and product.
    상세보기
  4. Okada Hiroaki (Suita JPX) Ogawa Yasuaki (Ibaraki JPX) Yashiki Takatsuka (Takarazuka JPX), Prolonged release microcapsule and its production.
    상세보기

이 특허를 인용한 특허 (86)

  1. Yamamoto Tameyuki (Kamakura JPX) Abiru Masao (Omiya JPX), Antiseptic-containing alginate impression material.
    상세보기
  2. Sankaram, Mantripragada, Biodegradable compositions for the controlled release of encapsulated substances.
    상세보기
  3. Peter Timmins GB; Andrew B. Dennis GB; Kiren A. Vyas GB, Biphasic controlled release delivery system for high solubility pharmaceuticals and method.
    상세보기
  4. Latta, Mark A.; Gross, Stephen M.; McHale, William A., Buffered microencapsulated compositions and methods.
    상세보기
  5. Chen, Guohua; Houston, Paul R.; Kleiner, Lothar; Spaltro, John, Catheter injectable depot compositions and uses thereof.
    상세보기
  6. Lee Hye-Jung ; Johnson OluFunmi L. ; Zale Stephen E. ; Tracy Mark A., Composition and method using solid-phase particles for sustained in vivo release of a biologically active agent.
    상세보기
  7. Zale Stephen E. (Hopkington MA) Burke Paul A. (Medford MA) Bernstein Howard (Cambridge MA) Brickner Avram (Brookline MA), Composition for sustained release of non-aggregated erythropoietin.
    상세보기
  8. Zale Stephen E. ; Burke Paul A. ; Bernstein Howard ; Brickner Avram, Composition for sustained release of non-aggregated erythropoietin.
    상세보기
  9. Cheng, Xiu Xiu; Jan, Steve; Chou, Joseph; Chen, Chih-Ming, Controlled release metformin formulations.
    상세보기
  10. Xiu Xiu Cheng ; Chih-Ming Chen ; Steve Jan ; Joseph Chou, Controlled release oral tablet having a unitary core.
    상세보기
  11. Ni,Yawei; Yates,Kenneth M., Delivery of physiological agents with in-situ gels comprising anionic polysaccharides.
    상세보기
  12. McHale, William A.; Brown, Dale G., Enamel protectant and repair brushing gels.
    상세보기
  13. Mchale, William A.; Brown, Dale G., Enamel protectant and repair toothpaste.
    상세보기
  14. Mchale, William A.; Brown, Dale G., Enamel protectant and repair toothpaste treatments.
    상세보기
  15. Heya Toshiro (Hyogo JPX) Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Kyoto JPX), Encapsulation of TRH or its analog.
    상세보기
  16. Farrar Graham Henry,GBX ; Tinsley-Bown Anne Margaret,GBX ; Jones David Hugh,CAX, Encapsulation of bioactive agents.
    상세보기
  17. Ni, Yawei; Yates, Kenneth M.; Zarzycki, Ryszard, High molecular weight, low methoxyl pectins, and their production and uses.
    상세보기
  18. Ni, Yawei; Yates, Kenneth M., In-situ gel formation of pectin.
    상세보기
  19. Chen, Guohua; Houston, Paul R.; Kleiner, Lothar Walter; Spaltro, John J., Injectable depot compositions and uses thereof.
    상세보기
  20. Chen, Guohua; Houston, Paul; Kleiner, Lothar; Wright, Jeremy, Injectable multimodal polymer depot compositions and uses thereof.
    상세보기
  21. Chou, Kang-Jye; Guo, Hong; Ashton, Paul; Shimizu, Robert W.; Watson, David A., Injectable sustained release delivery devices.
    상세보기
  22. McHugh,Anthony J.; DesNoyer,Jessica R., Injectable system for controlled drug delivery.
    상세보기
  23. Rahman Aquilur (Gaithersburg MD), Liposome-encapsulated vinca alkaloids and their use in combatting tumors.
    상세보기
  24. Bohm Howard A. (Richmond VA), Liquid controlled release formulations and method of producing same via multiple emulsion process.
    상세보기
  25. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Method for producing microcapsule.
    상세보기
  26. Okada Hiroaki (Osaka JPX) Ogawa Yasuaki (Osaka JPX) Yashiki Takatsuka (Hyogo JPX), Method for producing microcapsule.
    상세보기
  27. Polansky Jon R. (Mill Valley CA) Bloom Ernest (Alamo CA) Fauss Donald J. (San Francisco CA), Method for the treatment of a trabecular meshwork whose cells are subject to inhibition of cell division.
    상세보기
  28. Ashton, Paul, Method for treating and/or preventing retinal diseases with sustained release corticosteroids.
    상세보기
  29. Soper Jon C. ; Kim Young D. ; Thomas Margaret T., Method of encapsulating flavors and fragrances by controlled water transport into microcapsules.
    상세보기
  30. Soper Jon C. ; Yang Xiaogen ; Josephson David B., Method of encapsulating flavors and fragrances by controlled water transport into microcapsules.
    상세보기
  31. Emery Daryll A. ; Straub Darren E. ; Huisinga Richard, Method of inducing an immune response in a young animal.
    상세보기
  32. Jones David Hugh,GBX ; Farrar Graham Henry,GBX ; Clegg James Christopher Stephen,GBX, Method of making microencapsulated DNA for vaccination and gene therapy.
    상세보기
  33. Jones, David Hugh; Farrar, Graham Henry; Clegg, James Christopher Stephen, Method of making microencapsulated DNA for vaccination and gene therapy.
    상세보기
  34. Lencki Robert W. J. (1650 Lincoln Ave. ; Apt. 1101 Montreal ; Quebec CAX H3H 1H1) Neufeld Ronald J. (110 Westbank Ave. Pointe Claire ; Quebec CAX H9R 2X6) Spinney Trevor (3739 St. Dominique Montreal , Method of producing microspheres.
    상세보기
  35. Ahdieh, Harry, Method of treating pain utilizing controlled release oxymorphone pharmaceutical compositions and instruction on dosing for renal impairment.
    상세보기
  36. Ahdieh, Harry, Method of treating pain utilizing controlled release oxymorphone pharmaceutical compositions and instruction on dosing for renal impairment.
    상세보기
  37. Timmins, Peter; Dennis, Andrew B.; Vyas, Kiren A., Method of use of a biphasic controlled release delivery system for high solubility pharmaceuticals and method.
    상세보기
  38. McHale, William A.; Brown, Dale G., Methods for protecting and reparing enamel.
    상세보기
  39. Polansky Jon R. (Mill Valley CA) Bloom Ernest (Alamo CA) Fauss Donald J. (San Francisco CA), Methods for the cyto-protection of the trabecular meshwork.
    상세보기
  40. Jones, David Hugh; Farrar, Graham Henry; Clegg, James Christopher Stephen, Microencapsulated DNA for vaccination and gene therapy.
    상세보기
  41. Latta, Mark A.; Gross, Stephen M.; Mchale, William A., Microencapsulated compositions and methods for tissue mineralization.
    상세보기
  42. Mark A. Tracy ; Kevin L. Ward ; David S. Scher ; J. Keith Johnson, Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins.
    상세보기
  43. Wantier Henri (Dour BEX) Mathieu Fabienne (Nivelles BEX) Baudrihaye Marc (Waterloo BEX) Delacroix Dominique (Kraainem BEX), Microspheres for the controlled release of water-soluble substances and process for preparing them.
    상세보기
  44. Oberegger, Werner; Eradiri, Okponanabofa; Zhou, Fang; Maes, Paul, Modified release tablet of bupropion hydrochloride.
    상세보기
  45. Bernstein Howard ; Zhang Yan ; Khan M. Amin ; Tracy Mark A., Modulated release from biocompatible polymers.
    상세보기
  46. Bernstein, Howard; Zhang, Yan; Khan, M. Amin; Tracy, Mark A., Modulated release from biocompatible polymers.
    상세보기
  47. Howard Bernstein ; Yan Zhang ; M. Amin Khan ; Mark A. Tracy, Modulated release from biocompatible polymers.
    상세보기
  48. Ausborn Michael ; Bodmer David,CHX ; Nagele Oskar,CHX ; Marchal Laurent,FRX, Organic compounds.
    상세보기
  49. Emery, Daryll A.; Straub, Darren E., Ovo delivery of an immunogen containing implant.
    상세보기
  50. Kao, Haui-Hung; Baichwal, Anand R.; McCall, Troy; Lee, David, Oxymorphone controlled release formulations.
    상세보기
  51. Kao, Huai-Hung; Baichwal, Anand R.; McCall, Troy; Lee, David, Oxymorphone controlled release formulations.
    상세보기
  52. Kao, Huai-Hung; Baichwal, Anand R.; McCall, Troy; Lee, David, Oxymorphone controlled release formulations.
    상세보기
  53. Hung, Hao-Hsiang; Ting, Chia-Ching, Pharmaceutical composition containing guaifenesin and application thereof.
    상세보기
  54. Ni, Yawei; Yates, Kenneth M.; Zarzycki, Ryszard, Pharmaceutical compositions comprising aloe pectins, and methods for their production and use.
    상세보기
  55. Yano, Tetsuya; Nomoto, Tsuyoshi; Kozaki, Shinya; Imamura, Takeshi; Honma, Tsutomu, Polyhydroxyalkanoate-containing magnetic structure, and manufacturing method and use thereof.
    상세보기
  56. Lipham Luke B. (Athens GA) Stuedemann John A. (Athens GA) Thompson ; Jr. Frederick N. (Athens GA), Prevention of fescue toxicosis.
    상세보기
  57. Lee, Hee-Yong; Kim, Jung-Soo; Shin, Eun-Ho; Kim, Seong-Kyu; Seol, Eun-Young; Baek, Mi-Jin; Baek, Mi-Young; Chae, Yeon-Jin; Choi, Ho-Il; Lee, Juhan, Process of preparing microspheres for sustained release having improved dispersibility and syringeability.
    상세보기
  58. Hartounian, Hartoun; Meissner, Dagmar; Pepper, Clint B., Production of multivesicular liposomes.
    상세보기
  59. Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Mathiowitz Edith (Brookline MA) Schwaller Kirsten (Duxbury MA) Beck Thomas R. (Concord MA), Protein microspheres and methods of using them.
    상세보기
  60. McHale, William A.; Brown, Dale G., Remineralizing and desensitizing compositions, treatments and methods of manufacture.
    상세보기
  61. Chen, Guohua; Priebe, David, Short duration depot formulations.
    상세보기
  62. Chen, Guohua; Priebe, David T., Short duration depot formulations.
    상세보기
  63. Chen Jianbing ; Ashton Paul, Sustained release drug delivery devices.
    상세보기
  64. Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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  65. Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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  66. Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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  67. Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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  68. Hong Guo ; Paul Ashton, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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  69. Baichwal,Anand R.; Kao,Huai Hung; McCall,Troy W., Sustained release formulations of oxymorphone.
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  70. Kim, Sinil; Kim, Taehee; Murdande, Sharad, Sustained-release liposomal anesthetic compositions.
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  71. Kim, Sinil; Kim, Taehee; Murdande, Sharad, Sustained-release liposomal anesthetic compositions.
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  72. Kim, Sinil; Kim, Taehee; Murdande, Sharad, Sustained-release liposomal anesthetic compositions.
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  73. Kim, Sinil; Kim, Taehee; Murdande, Sharad, Sustained-release liposomal anesthetic compositions.
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  74. Machida Minoru (Tokyo JPX) Arakawa Masayuki (Shizuoka JPX), Sustained-release particulate preparation and process for preparing the same.
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  75. Saito, Kazuhiro; Futo, Tomomichi; Hoshino, Tetsuo, Sustained-release preparations.
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  76. McHale, William A.; Brown, Dale G., Topical ubiquinol oral supplement compositions with amorphous calcium phosphate.
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  77. McHale, William A.; Brown, Dale G., Topical vitamin D and ubiquinol oral supplement compositions.
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  78. McHale, William A.; Brown, Dale G., Topical vitamin D oral supplement compositions.
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  79. Moore, Keith A.; Heasley, Ralph A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations.
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  80. Moore, Keith A.; Heasley, Ralph A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations.
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  81. Moore, Keith A.; Heasley, Ralph A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations.
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  82. Moore, Keith A.; Heasley, Ralph A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations.
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  83. Moore, Keith A.; Heasley, Ralph A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations.
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  84. Moore, Keith A.; Heasley, Ralph A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations.
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  85. Moore, Keith A.; Heasley, Ralph A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations.
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  86. Heasley, Ralph A.; Moore, Keith A.; Greiwe, Jeffrey S.; Facemire, John W.; Modest, Jason D., Tranexamic acid formulations with reduced adverse effects.
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