[특허]Methods and apparatus for iontophoresis application of medicaments

Methods and apparatus for iontophoresis application of medicaments 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61N-001/30
출원번호	US-0841329 (1986-03-19)
발명자 / 주소	Petelenz Tomasz J. (Salt Lake City UT) Stephen Robert L. (Salt Lake City UT) Jacobsen Stephen C. (Salt Lake City UT)
출원인 / 주소	The University of Utah Research Foundation (Salt Lake City UT 02)
인용정보	피인용 횟수 : 96 인용 특허 : 0

초록 ▼

Methods and apparatus for administering known quantities of medicaments by iontophoresis while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current are disclosed. It has been found that, as iontophoresis progresses in conventional iontophoresis systems, the electrolysis of water occurs to produce hydrogen or hydroxyl ions at the interface of the electrode and medicament medium. Since these ions are highly mobile, they are transported directly into the skin of patient in preference to the larger medicament ions. Thus, extreme changes in pH are experienced which result in burns due to the acidification or alkalinization of the medicament medium and passage of electric current through the skin. The present invention also avoids the production of other competing ions by employing a reactive electrode. The electrode and the medicament are chosen such that the electrode will react with the complementary ion (the ion which forms upon the dissociation of the medicament in solution) to form an insoluble material.

대표청구항 ▼

A method for iontophoretically administering a medicament through the skin of a patient while minimizing the formation of competing ions in the medicament medium, the method comprising the steps of: (a) obtaining a first electrode comprised of silver and a second electrode; (b) obtaining a medicament dissolved in an aqueous medium so as to form medicament ions and complementary ions, said complementary ions being chloride ions capable of reacting with the first electrode to form an insoluble silver chloride precipitate; (c) placing the first electrode in communication with the medicament medium; (d) placing the medicament medium in communication with the patient such that the medium is disposed between the first electrode and the skin of the patient; (e) placing the second electrode in communication with the skin of the patient at a point separated from the first electrode; (f) creating an electrical voltage difference between the first and second electrodes, said voltage difference transporting the medicament ions through the skin of the patient, said voltage difference causing a reaction which results in the formation of a silver chloride precipitate by the reaction of the complementary ion with the first electrode, thereby avoiding formation of additional ions which would compete for charge transport with the medicament ions and reduce the amount of medicament administered to the patient; and maintaining a voltage at the interface of the first electrode and the medicament medium below a voltage at which electrolysis of the water in the aqueous medicament medium can occur.

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

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연합인증

Methods and apparatus for iontophoresis application of medicaments 원문보기

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Methods and apparatus for iontophoresis application of medicaments 원문보기

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