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Thrombin aerosol 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-009/14
  • A61K-035/14
  • A61K-037/00
출원번호 US-0091165 (1987-08-31)
발명자 / 주소
  • Saferstein Lowell (Edison NJ) Wolf Stephen J. (Manville NJ)
출원인 / 주소
  • Johnson & Johnson Products, Inc. (New Brunswick NJ 02)
인용정보 피인용 횟수 : 56  인용 특허 : 0

초록

A process is disclosed for delivery thrombin in dry powdered form from an aerosol container by first lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer e.g. polyvinyl pyrrolidone, placing the lyophilized cake in a pressure bottle by crimping on a valve stem and

대표청구항

The process of delivering thrombin in dry powdered form from a valve-actuated, pressurized, propellant-containing aerosol container comprising the following steps: (a) lyophilizing an aqueous solution of thrombin and a thrombin-compatible synthetic polymer (b) placing the resultant lyophilized throm

이 특허를 인용한 특허 (56)

  1. Dowling, Matthew; Raghavan, Srinivasa, Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds.
  2. Diehn, Kevin; Dowling, Matthew; Raghavan, Srinivasa R.; King, David R., Advanced functional biocompatible polymer putty used as a hemostatic agent for treating damaged tissue and cells.
  3. Raghavan, Srinivasa R.; Payne, Gregory F.; Zhu, Chao; Dowling, Matthew B., Advanced functional biocompatible polymeric matrix containing nano-compartments.
  4. Dowling, Matthew; Hess, John; Bochicchio, Grant; Raghavan, Srinivasa, Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells.
  5. Dowling, Matthew; Hess, John; Bochicchio, Grant; Raghavan, Srinivasa, Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells.
  6. Gertner, Michael E., Aerosol device to deliver bioactive agent.
  7. Coelho Philip Henry ; Kingsley Phil ; Brausch Jim ; Godsey James H. ; Rock Gail,CAX, Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby.
  8. Coelho,Philip Henry; Kingsley,Phil; Brausch,Jim; Godsey,James H.; Rock,Gail, Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby.
  9. Ducharme, Richard W.; Sugg, David E., Apparatus and methods for containing and delivering therapeutic agents.
  10. Ducharme, Richard W., Apparatus and methods for delivering therapeutic agents.
  11. Cederholm-Williams Stewart A.,GBX ; Weis-Fogh Ulla,DKX, Composition containing autologous thrombin blood fraction for use in a medical procedure.
  12. Suh, Janette; Cornelius, Gay; McKechnie, Malcolm Tom; Thompson, Ian Andrew, Deactivants for dust mite allergens.
  13. Suh, Janette; Cornelius, Gay; McKechnie, Malcolm Tom; Thompson, Ian Andrew, Deactivants for dust mite allergens.
  14. Larsen, Kristian; Sabra, Mads, Device for promotion of hemostasis and/or wound healing.
  15. Larsen, Kristian; Sabra, Mads, Device for promotion of hemostasis and/or wound healing.
  16. Larsen, Kristian, Dry composition comprising an extrusion enhancer.
  17. Larsen, Kristian, Dry haemostatic composition.
  18. Larsen, Kristian, Dry haemostatic composition.
  19. Whitfield, Nicola; Koopman, Jaap; Grimbergen, Jos, Dry powder fibrin sealant.
  20. Leon Wortham, Fibrin glue without fibrinogen and biosealant compositions and methods.
  21. Wortham Leon, Fibrin glue without fibrinogen and biosealant compositions and methods.
  22. Schutte, Eliane; Zuckerman, Linda; Senderoff, Richard; Martyn, Glen, Formulations for wound therapy.
  23. Ecanow Bernard (Wilmette IL), Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs.
  24. Looney, Dwayne Lee; Troger, Kenneth; Lamb, Bruce; Walthall, Benjamin, Hemostatic devices and methods of making same.
  25. Jo,Yoshio; Aoshima,Motonori; Tanabe,Koji; Matsushita,Koichi; Inoue,Toshiki, Hemostatic soluble cellulose fibers containing coagulating protein for treating wound and process for producing the same.
  26. Saferstein Lowell (Edison NJ) Wolf Stephen J. (Neshanic Station NJ), Hemostatic thrombin paste composition.
  27. Guo,Jian Xin; Looney,Dwayne Lee; Zhang,Guanghui; Gorman,Anne Jessica, Hemostatic wound dressing and method of making same.
  28. Looney,Dwayne Lee; Crilley,John; Guo,Jian Xin; Zhang,Guanghui; Pendharkar,Sanyog Manohar, Hemostatic wound dressings and methods of making same.
  29. Looney,Dwayne Lee; Guo,Jian Xin; Zhang,Guanghui; Pendharkar,Sanyog Manohar; Gorman,Anne Jessica; Craven,Thomas Lee; Bermel,Michelle, Hemostatic wound dressings and methods of making same.
  30. Campbell, James N.; Michaelis, Arthur F., High concentration local anesthetic formulations.
  31. Campbell, James N.; Michaelis, Arthur F., High concentration local anesthetic formulations.
  32. Radhakrishnan Ramachandran (Fremont CA) Mihalko Paul J. (Fremont CA) Abra Robert M. (San Francisco CA), Method and apparatus for administering dehydrated liposomes by inhalation.
  33. Dowling, Matthew; Raghavan, Srinivasa R.; Dashaputre, Neeraja; English, Douglas Stephen; Javvaji, Vishal; Payne, Gregory F.; DeShong, Philip R., Method and system for capture and use of intact vesicles on electrodeposited hydrophobically modified biopolymer films.
  34. Dowling, Matthew; Raghavan, Srinivasa R.; Kumar, Rakesh, Method and system for reversal of interactions between hydrophobically modified biopolymers and vesicles or cell membranes.
  35. Philip Henry Coelho ; Phil Kingsley ; Jim Brausch ; James H. Godsey ; Gail Rock CA; Trista K. Madsen ; Sona B. Frausto, Method for preparing thrombin for use in a biological glue.
  36. Dolecek,Victor D.; Baugh,Robert F.; Rivera,John G.; McKay,William F.; Marx,Jeffery C., Method for the production of a blood component composition.
  37. Gorman, Anne Jessica; Pendharkar, Sanyog Manohar, Method of making a reinforced absorbable multilayered hemostatic wound dressing.
  38. Cederholm-Williams Stewart A.,GBX ; Weis-Fogh Ulla,DKX, Method of use of autologous thrombin blood fraction in a cell culture with keratinocytes.
  39. Heath David,GBX ; Middleton Sarah Margaret,GBX, Microparticles and their use in wound therapy.
  40. Mistry, Suresh N; Gibson, Mark, Pressurized aerosol compositions comprising powdered medicament dispersed in hydrofluoroalkane.
  41. Mistry Suresh N,GBX ; Gibson Mark,GBX, Pressurized aerosol inhalation compositions.
  42. Goessl, Andreas, Process for making dry and stable hemostatic compositions.
  43. Goessl, Andreas; Osawa, Atsushi Edward; Reich, Cary J., Process for making dry and stable hemostatic compositions.
  44. Goessl, Andreas; Osawa, Atsushi Edward; Reich, Cary J., Process for making dry and stable hemostatic compositions.
  45. Goessl, Andreas; Osawa, Atsushi Edward; Reich, Cary J., Process for making dry and stable hemostatic compositions.
  46. Lee, Janet S.; Corcoran, Timothy E.; Kagan, Valerian, Red blood cell membrane-derived microparticles and their use for the treatment of lung disease.
  47. Shetty, Dhanuraj S.; Pendharkar, Sanyog Manohar; Gorman, Anne Jessica; Kalirai, Simmi, Reinforced absorbable multilayered fabric for use in medical devices.
  48. Dhanaraj, Sridevi; Shetty, Dhanuraj S.; Do, Hiep; Pendharkar, Sanyog Manohar, Reinforced absorbable multilayered fabric for use in tissue repair and regeneration.
  49. Gorman, Anne Jessica; Pendharkar, Sanyog Manohar; Zhang, Guanghui; Bar, Liliana; Nur, Israel; Meidler, Roberto, Reinforced absorbable multilayered hemostatis wound dressing.
  50. Ducharme, Richard W, Systems and methods for delivering therapeutic agents.
  51. Ducharme, Richard W.; Sugg, David E.; Skelton, Eugene E.; Bruggemann, Martin; Bryce, Lyndsey, Systems and methods for delivering therapeutic agents.
  52. Ducharme, Richard W.; Sugg, David E.; Skelton, Eugene; Bruggemann, Martin; Bryce, Lyndsey, Systems and methods for delivering therapeutic agents.
  53. Ducharme, Richard W.; Sugg, David E.; Skelton, Eugene; Bruggemann, Martin; Bryce, Lyndsey, Systems and methods for delivering therapeutic agents.
  54. Gittard, Shaun D., Therapeutic agents for delivery using a catheter and pressure source.
  55. Brown, Marc Barry; Jones, Stuart Allen, Topical formulations.
  56. Larsen, Kristian; Mortensen, Michael Wrang, Vacuum expanded dry composition and syringe for retaining same.
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