초록 ▼

A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhanc

A dispensing system is disclosed comprising a wall surrounding a lumen. The lumen comprises (1) a thermo responsive composition comprising a beneficial agent, (2) means for occupying space in the lumen for pushing the thermo responsive composition from the dispensing system, and (3) means for enhancing the amount of the beneficial agent dispensed from the system positioned between the thermo responsive composition and the means for occupying space.

대표청구항 ▼

A delivery system for delivering a beneficial agent formulation to an environment of use, the delivery system comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising a semipermeable composition that is permeable to the passage of fluid and substantially impermeable t

A delivery system for delivering a beneficial agent formulation to an environment of use, the delivery system comprising: (a) a wall that surrounds and defines an internal lumen, the wall comprising a semipermeable composition that is permeable to the passage of fluid and substantially impermeable to the passage of a beneficial agent; (b) a hydrogel composition in the lumen which expands and occupies an increased volume of the lumen upon imbibing fluid; (c) a heat sensitive beneficial agent formulation in the lumen that forms a dispensable formulation at a temperature of at least 25°C.; (d) lamina means in the lumen for lessening the incidence of mixing of the heat-sensitive beneficial agent formulation with the hydrogel composition, said lamina means being positioned between the heat-sensitive beneficial agent formulation and the hydrogel composition; and (e) means in the delivery system for communicating with the lumen for delivering the beneficial agent formulation to the environement of use over time.