[특허]Polypeptide cartilage-inducing factors found in bone used in tissue proliferation

Polypeptide cartilage-inducing factors found in bone used in tissue proliferation 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61F-002/00 A61K-037/12 A61K-035/12
출원번호	US-0130884 (1987-12-10)
발명자 / 주소	Seyedin Saeid (Sunnyvale CA) Thomas Thomas (Concord CA) Bentz Hanne (Palo Alto CA) Ellingsworth Larry (San Jose CA) Armstrong Rosa (Palo Alto CA)
출원인 / 주소	Collagen Corporation (Palo Alto CA 02)
인용정보	피인용 횟수 : 79 인용 특허 : 5

초록 ▼

Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-bbb

대표청구항 ▼

A method of promoting proliferation of soft tissue cells in an animal comprising administering a composition comprising (a) a polypeptide that (i) is active in the TGF-b assay; and (ii) is a dimer having a molecular weight of approximately 26,000 daltons as determined by SDS-PAGE, whose chains each have the following N-terminal sequence: Ala-Leu-Asp-Ala-Ala-Tyr-Cys-Phe-Arg-Asn-Val-Gln-Asp-Asn-Cys-Cys-Leu-Arg-Pro-Leu-Tyr-Ile-Asp-Phe-Lys-Arg-Asp-Leu-Gly-Trp-; (b) a TGF-b activating agent; and (c) a pharmaceutically acceptable carrier, said polypeptide and activating agent being present in amounts that promote normal cell proliferation to the animal.

이 특허에 인용된 특허 (5)

Jefferies Steven R. (5802 Leith Walk Baltimore MD 21239), Bone graft material for osseous defects and method of making same.
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Urist Marshall R. (Pacific Palisades CA), Bone morphogenetic protein.
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Urist Marshall R. (Pacific Palisade CA), Bone morphogenetic protein process.
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Nathan Ranga (Newark CA) Seyedin Saied (Mountain View CA) Piez Karl (Menlo Park CA) Bentz Hanne (Palo Alto CA), Inductive collagen based bone repair preparations.
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Seyedin Saeid (Mt. View CA) Thomas Thomas (Palo Alto CA), Partially purified osteogenic factor and process for preparing same from demineralized bone.
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이 특허를 인용한 특허 (79)

Celeste Anthony J. ; Wozney John M., Antibodies to bone morphogenetic protein-10 (BMP-10).
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Wang Elizabeth A. ; Wozney John M. ; Rosen Vicki A., BMP products.
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Wang,Elizabeth A.; Wozney,John M.; Rosen,Vicki A., BMP products.
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Celeste Anthony J. ; Wozney John M. ; Rosen Vicki A. ; Wolfman Neil M. ; Thomsen Gerald H. ; Melton Douglas A., BMP-12 and BMP-13 proteins and DNA encoding them.
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Wang Elizabeth A. (Carlisle MA) Wozney John M. (Hudson MA) Rosen Vicki (Brookline MA), BMP-2 products.
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Wang Elizabeth A. ; Wozney John M. ; Rosen Vicki, BMP-3 products.
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Wang Elizabeth A. ; Wozney John M. ; Rosen Vicki A., BMP-4 products.
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Wozney John M. ; Wang Elizabeth A. ; Rosen Vicki A. ; Celeste Anthony J., BMP-6 proteins.
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Wozney, John M.; Wang, Elizabeth A.; Rosen, Vicki A.; Celeste, Anthony J., BMP-6 proteins.
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Rosen Vicki A. ; Wozney John M. ; Celeste Anthony J. ; Thies R. Scott ; Song Jeffrey R., BMP-9 compositions.
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Rosen Vicki A. ; Wozney John M. ; Celeste Anthony J. ; Thies Scott R. ; Song Jeffrey R., BMP-9 compositions.
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Wasielewski, Ray C., Biologically reabsorbable acetabular constraining components and materials for use with a hip replacement prosthesis and bioreabsorbable materials to augment hip replacement stability and function.
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Hewick,Rodney M.; Wang,Jack H.; Wozney,John M.; Celeste,Anthony J., Bone and cartilage inductive proteins.
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Thorne, Kevin J., Bone growth particles and osteoinductive composition thereof.
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Behnam, Keyvan, Bone matrix compositions and methods.
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Behnam, Keyvan, Bone matrix compositions and methods.
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Behnam, Keyvan; Cioffi, Christopher, Bone matrix compositions and methods.
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Behnam, Keyvan; Wei, Guobao; Forsyth, Nanette, Bone matrix compositions and methods.
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Behnam, Keyvan; Wei, Guobao; Forsyth, Nanette; Boyce, Todd M.; Shimp, Lawrence A., Bone matrix compositions and methods.
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Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette, Bone matrix compositions having nanoscale textured surfaces.
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Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette, Bone matrix compositions having nanoscale textured surfaces.
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Wozney John M. ; Wang Elizabeth A. ; Rosen Vicki A. ; Celeste Anthony J., Bone morphogenetic protein (BMP)--6.
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Thies R. Scott ; Song Jeffrey J., Bone morphogenetic protein (BMP)-9 compositions and their uses.
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Celeste Anthony J. (Hudson MA) Wozney John M. (Hudson MA), Bone morphogenetic protein-10 (BMP-10) compositions.
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Elizabeth A. Wang ; John M. Wozney ; Vicki Rosen, Bone morphogenetic protein-3 and compositions.
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Akella, Rama; Garrett, Ian Ross; Wen, Hai Bo; Li, Shuliang; Acker, Dean M.; Wilhelm, Nichole, Bone void fillers.
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Li,Rebecca H.; Seeherman,Howard, Calcium phosphate delivery vehicles for osteoinductive proteins.
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McPherson John M. ; Yaeger Peter C. ; Brown Marie E. ; Hanlon James G. ; Binette Francois,CAX, Chondrocyte media formulations and culture procedures.
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Thorne, Kevin J., Composition and process for bone growth and repair.
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Clancy,Brian; Pittman,Debra; Seeherman,Howard, Compositions and methods for systemic administration of sequences encoding bone morphogenetic proteins.
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Atkinson, Brent; Benedict, James J., Compositions for regeneration and repair of cartilage lesions.
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Hewick Rodney M. (Lexington MA) Wang Jack H. (Lexington MA) Wozney John M. (Hudson MA) Celeste Anthony J. (Hudson MA), DNA encoding and methods for producing BMP-8 proteins.
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Wozney,John M.; Celeste,Anthony J.; Thies,R. Scott; Yamaji,Noboru, DNA molecules encoding BMP receptor proteins.
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Celeste Anthony J. (Hudson MA) Wozney John M. (Hudson MA), DNA molecules encoding bone morphogenetic protein-10.
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Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd M., Delivery system.
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Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd M.; Berven, Sigurd H.; Betz, Randal R.; O'Brien, Michael F.; Shelokov, Alexis P., Delivery system.
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Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd M.; Attawia, Mohamed; Richards, Cristy J.; Shimp, Lawrence A., Delivery system attachment.
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Wei, Guobao; Behnam, Keyvan; Forsyth, Nanette; Winterbottom, John; Beisser, James; Boyce, Todd; Attawia, Mohamed; Richards, Cristy J.; Shimp, Lawrence A., Delivery system attachment.
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Wei, Guobao; Boyce, Todd M.; Shimp, Lawrence A., Delivery system cartridge.
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Betz, Randal R.; Boden, Scott; Gupta, Munish Chandra; O'Brien, Michael F.; Sandhu, Harvinder; Shelokov, Alexis; Sybert, Daryl R.; Vaccaro, Alexander; Wei, Guobao; Boyce, Todd M.; Cohen, Robert; Richards, Cristy; Shimp, Lawrence A., Delivery systems, tools, and methods of use.
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Behnam, Keyvan; Wei, Guobao; Beisser, James, Demineralized bone matrix compositions and methods.
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Behnam, Keyvan; Wei, Guobao; Beisser, James A., Demineralized bone matrix compositions and methods.
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Veis Arthur (Skokie IL) Sires Bryan S. (Chicago IL), Dentin chondrogenic inductive agent.
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Dunn,Richard L., Emulsions for in-situ delivery systems.
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Li, Rebecca; Seeherman, Howard; Kim, Hyun, Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins.
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Li, Rebecca; Seeherman, Howard; Kim, Hyun, Injectable calcium phosphate solid rods and pastes for delivery of osteogenic proteins.
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Kim,Hyun; Li,Rebecca; Pavesio,Alessandra; Callegaro,Lanfranco; Seeherman,Howard; Wozney,John, Injectable carrier formulations of hyaluronic acid derivatives for delivery of osteogenic proteins.
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Louis Junker ; Michael Lewis ; Robert Nelson, Isolation of purified TGF- .beta.1 and TGF -.beta.2 from bone tissue.
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Shimp, Lawrence A.; Wei, Guobao; Behnam, Keyvan, Method of treating bone tissue.
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Zhang,Renwen; Peluso,Diane; Morris,Elisabeth, Methods and compositions for healing and repair of articular cartilage.
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Hunziker Ernst B. (Riedholz CHX), Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone.
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Gruskin, Elliott A.; Buechter, Douglas D.; Zhang, Guanghui; Connelly, Kevin, Methods for producing extracellular matrix proteins.
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Rosen Vicki A. ; Wozney John M. ; Wang Elizabeth A., Methods of administering BMP-5 compositions.
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Celeste Anthony J. (Hudson MA) Wozney John M. (Hudson MA) Rosen Vicki A. (Brookline MA) Wolfman Neil M. (Dover MA) Thomsen Gerald H. (Port Jefferson NY) Melton Douglas A. (Lexington MA), Methods of inducting formation of tendon and/or ligament tissue comprising administering BMP-12, BMP-13, and/or MP-52.
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Wang,Elizabeth; Wozney,John M.; Rosen,Vicki A., Methods of treatment of periodontal disease.
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Derynck Rik M. A. ; Goeddel David V., Nucleic acid encoding TGF-.beta. and its uses.
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Derynck Rik M. A. (So. San Francisco CA) Goeddel David V. (Hillsborough CA), Nucleic acid encoding TGF-b 상세보기

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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

연합인증

Polypeptide cartilage-inducing factors found in bone used in tissue proliferation 원문보기