초록 ▼

An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme in

An osmotic system is disclosed comprising a wall comprising in at least a part of a semipermeable material that surrounds a compartment. The compartment contains a first osmotic composition comprising a beneficial drug selected from the group consisting of a calcium antagonist, angiotensin enzyme inhibitor and nonsteroidal antiinflammatory drugs, and a second and different osmotic composition. A passageway in the wall connects the first composition with the exterior of the system.

대표청구항 ▼

An osmotic device for the oral administration at a controlled rate a beneficial angiotensin converting enzyme inhibitor to an enviromment of use, the osmotic device comprising: (a) a wall comprising at least in part a composition permeable to the passage of an exterior fluid present in the environme

An osmotic device for the oral administration at a controlled rate a beneficial angiotensin converting enzyme inhibitor to an enviromment of use, the osmotic device comprising: (a) a wall comprising at least in part a composition permeable to the passage of an exterior fluid present in the environment of use, the wall surrounding and forming: (b) a compartment; (c) a first composition in the compartment, said first composition comprising a dosage amount of an angiotensin converting enzyme inhibitor and an osmopolymer that exhibits an osmotic pressure gradient across the wall aganist an external aqueous fluid, which osmopolymer imbibes and absorbs aqueous fluid that enters the compartment to form a dispensable composition comprising the angiotension converting enzyme inhibitor; (d) a second composition in the compartment, said second composition comprising an osmopolymer that exhibits an osmotic pressure gradient across the wall against an external fluid; and, (e) at least one passageway in the wall connecting the exterior of the device with the interior of the device for delivering the composition comprising the angiotensin converting enzyme inhibitor from the osmotic device.