초록 ▼

This invention relates to the resolution of racemic mixtures of optically active compounds, including but not limited to the stereochemical purification of chiral organic esters, amides, carboxylic acids, alcohols, and amines. Novel methods utilizing multiphase and extractive enzyme membrane bioreac

This invention relates to the resolution of racemic mixtures of optically active compounds, including but not limited to the stereochemical purification of chiral organic esters, amides, carboxylic acids, alcohols, and amines. Novel methods utilizing multiphase and extractive enzyme membrane bioreactors are disclosed that selectively produce pure or substantially purified optically active compounds from achiral precursors or mixtures of isomers in which one or several of those isomers are biologically inactive or otherwise lack desirable characteristics. There are immiscible solvents on either side of the membrane.

대표청구항 ▼

A method for resolving a racemic mixture comprising: a. providing in a first fluid a racemic mixture having at least a first and second stereoisomer to one side of an enzyme activated membrane wherein said enzyme which activates said membrane catalyzes the reaction of the first stereoisomer into a c

A method for resolving a racemic mixture comprising: a. providing in a first fluid a racemic mixture having at least a first and second stereoisomer to one side of an enzyme activated membrane wherein said enzyme which activates said membrane catalyzes the reaction of the first stereoisomer into a chiral product having an altered chemical composition; b. providing concurrently a second fluid, substantially immiscible in said first fluid, to the opposite side of said enzyme activated membrane, whereby said racemic mixture is resolved with said chiral product of step a principally diffusing into said second fluid from said enzyme activated membrane so that said second fluid predominantly includes said chiral product and said first fluid predominantly includes said second stereoisomer.