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Body implants of extracellular matrix and means and methods of making and using such implants 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A01N-001/02
  • A61L-017/00
출원번호 US-0582504 (1984-02-22)
발명자 / 주소
  • Brendel Klaus (Tucson AZ) Duhamel Raymond C. (Tucson AZ)
출원인 / 주소
  • University Patents, Inc. (Westport CT 02)
인용정보 피인용 횟수 : 345  인용 특허 : 3

초록 ▼

A sterile body implant is derived from a body structure having as its major protein component collagens in the form of extracellular matrix. The body structure is treated to remove cellular membranes, nucleic acids, lipids and cytoplasmic components. Such structures are implanted internally in the b

대표청구항

A sterile body implant comprising a body derived structure having as its major component collagens and elastin in the form of extracellular matrix from which has been removed cellular membranes, nucleic acids, lipids and cytoplasmic components.

이 특허에 인용된 특허 (3)

  1. Reid Lola C. M. (Rye NY) Rojkind Marcos (Ciudad Satelite MXX), Method and article for culturing differentiated cells.
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  3. Fraefel, Wolfgang; Lichti, Heinz F.; Brunetti, Massimo, Process for the preparation of new organ transplants.
    상세보기

이 특허를 인용한 특허 (345)

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  147. Kladakis, Stephanie M.; Bowman, Steven M.; Steckel, Robert R., Meniscal repair scaffold.
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  148. Stone Kevin R., Meniscal xenografts.
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  149. Stone Kevin R. ; Galili Uri, Meniscal xenografts.
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  150. Wright, David Walter; Schein, Douglas; Brassil, John, Method and apparatus for controlling air pressure in an organ or tissue container.
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  151. Wright, David Walter; Schein, Douglas; Brassil, John, Method and apparatus for controlling air pressure in an organ or tissue container.
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  152. Charles S. Love, Method and apparatus for forming vascular prostheses.
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  153. Love Charles S., Method and apparatus for forming vascular prostheses.
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  154. Schein, Douglas; Travis, Lee William, Method and apparatus for holding a plurality of tubes connectible to an organ or tissue container.
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  155. Ball,Robert, Method and apparatus for implantation of soft tissue implant.
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  156. Fish, R. David, Method and apparatus for the endoluminal delivery of intravascular devices.
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  157. Garland, Jeffrey C.; Schein, Douglas; Wright, David Walter, Method and apparatus for transferring heat to or from an organ or tissue container.
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  158. Garland, Jeffrey C; Schein, Douglas; Wright, David Walters, Method and apparatus for transferring heat to or from an organ or tissue container.
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  159. Bell Eugene, Method and construct for producing graft tissue from an extracellular matrix.
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  160. Bell Eugene, Method and construct for producing graft tissue from an extracellular matrix.
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  161. Eugene Bell, Method and construct for producing graft tissue from an extracellular matrix.
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  162. Bell Eugene, Method and construct for producing graft tissue from extracellular matrix.
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  163. Wolfinbarger, Jr., Lloyd, Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof.
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  164. Robert G. Dennis ; William M. Kuzon, Jr. ; Paul S. Cederna, Method for chemically acellularizing a biological tissue sample.
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  165. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J.; Fraser, Richard; Harris, Stanley; Schein, Douglas, Method for controlling perfusion of an organ.
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  166. Konertz, Wolfgang; Dohmen, Pascal, Method for decellularizing foreign material to produce bioprostheses.
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  167. Bonutti,Peter M., Method for harvesting and processing cells from tissue fragments.
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  168. Fofonoff Timothy W. ; Bell Eugene, Method for spinning and processing collagen fiber.
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  169. Bonutti,Peter M., Method for tissue grafting.
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  170. Paul L. Termin ; Robert M. Carr, Jr. ; Kimberlie D. Condon, Method for treating diseased or damaged organs.
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  171. Termin, Paul L.; Carr, Jr., Robert M.; Condon, Kimberlie D., Method for treating diseased or damaged organs.
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  172. Barofsky,Andrew D.; Gregory,Kenton W., Method for using tropoelastin and for producing tropoelastin biomaterials.
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  173. Bonutti,Peter M., Method for utilizing human tissue.
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  174. Paniagua, David; Fish, R. David, Method of controlled release of a percutaneous replacement heart valve.
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  175. Brassil, John; Schein, Douglas; Curtis, Christopher, Method of determining that an organ is not suitable for transplantation and using it for testing substances.
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  176. Owen, Donald R.; Kravitz, David C.; Brassil, John; Brockbank, Kelvin G. M.; Burroughs, Andrew; Isaacs, Dickon; Steibel, Dennis J; Fraser, Richard; Harris, Stanley; Schein, Douglas; Curtis, Christopher G., Method of determining transport and/or storage parameters for maintaining viability of an organ.
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  177. McKay, William F.; Trieu, Hai H., Method of implanting natural tissue within the vertebral disc nucleus space using a drawstring.
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  178. Abraham,Ginger A.; Sullivan,Susan J.; Murray,James, Method of making a bioremodelable vascular graft prosthesis.
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  179. Jamiolkowski, Dennis D.; Brown, Kelly R.; Chun, Iksoo; Melican, Mora Carolynne, Method of preparation of bioabsorbable porous reinforced tissue implants and implants thereof.
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  180. Huang, Yen-Chen; Ivery, Asia; Choi, Bryan; Schilling, Benjamin; Ngo, Manh-Dan, Method of preparing an adipose tissue derived matrix.
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  181. Abraham,Ginger A.; Murray,James; Bachrach,Nathaniel M., Method of preparing layered graft prostheses.
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  182. Kevin R. Stone, Method of preparing xenograft heart valves.
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  183. Hu Jie, Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant.
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  184. Kenton W. Gregory, Method of producing elastin, elastin-based biomaterials and tropoelastin materials.
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  185. Gregory Kenton W., Method of producing fused biomaterials and tissue.
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  186. Ferree, Bret A., Method of providing cells and other biologic materials for transplantation.
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  187. Plouhar, Pamela L.; Dunn, Michael D.; Lower, Jerry L.; May, Thomas C., Method of reconstructing a joint.
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  188. Cox James L., Method of replacing atrioventricular heart valves using flexible tubes.
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  189. Bonutti, Peter M., Method of securing body tissue.
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  190. Bonutti, Peter M., Method of securing tissue.
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  191. Owen, Donald R.; Kravitz, David C., Method of transporting and storing a kidney.
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  192. Gregory Kenton W. ; Grunkemeier John M., Method of use of a sheet of elastin or elastin-based material.
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  193. Bonutti, Peter M.; Cremens, Matthew J.; Ruholl, Kevin, Method of using ultrasonic vibration to secure body tissue with fastening element.
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  194. Ferree, Bret A., Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft.
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  195. Ferree, Bret A., Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft.
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  196. Ferree, Bret A., Methods and apparatus for treating disc herniation and preventing the extrusion of interbody bone graft.
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  197. Anthony Atala, Methods and compositions for organ decellularization.
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  198. Atala, Anthony, Methods and compositions for organ decellularization.
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  199. Anthony Atala, Methods and compositions for producing artificial fascia.
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  200. Moehlenbruck, Jeffrey William; Ranieri, John Paul, Methods and compositions for treating intervertebral disc degeneration.
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  201. Moehlenbruck, Jeffrey William; Ranieri, John Paul, Methods and compositions for treating intervertebral disc degeneration.
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  202. Trieu, Hai H.; McKay, William F.; Sherman, Michael C.; Serbousek, Jon C., Methods for augmenting or repairing intervertebral discs with allogenic/xenogenic implants.
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  203. Bell Eugene ; Fofonoff Timothy W., Methods for preparing biopolymer foams.
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  204. Farrell, Laura-Lee; Johnson, Chad E., Methods for producing ECM-based biomaterials.
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  205. Farrell, Laura-Lee; Johnson, Chad E., Methods for producing ECM-based biomaterials.
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  206. Gratzer, Paul F., Methods for tissue decellularization.
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  207. Ross, Jeffrey; Porter, Blaise, Methods of decellularizing bone.
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  208. Taylor, Doris; Kren, Stefan M., Methods of recellularizing a tissue or organ for improved transplantability.
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  209. Masters, David B.; Berg, Eric P., Mucoadhesive drug delivery devices and methods of making and using thereof.
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  210. Hiles, Michael C.; Patel, Umesh H., Multi-formed collagenous biomaterial medical device.
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  211. Hiles, Michael C.; Patel, Umesh H., Multi-formed collagenous biomaterial medical device.
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  212. Hiles, Michael C.; Patel, Umesh H., Multi-formed collagenous biomaterial medical device.
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  213. Hiles, Michael C.; Patel, Umesh H., Multi-formed collagenous biomaterial medical device for use in wound care.
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  214. Ferree, Bret A., Natural and synthetic supplements to engineered annulus and disc tissues.
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  215. Freidberg Carlos Vonderwalde,MXX, Non-thrombogenic stent jacket.
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  216. Vonderwalde, Carlos, Non-thrombogenic stent jacket.
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  217. Dhanaraj, Sridevi; Kladakis, Stephanie M.; Hammer, Joseph J.; Shetty, Dhanuraj; Timmer, Mark, Nonwoven tissue scaffold.
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  218. Dhanaraj, Sridevi; Kladakis, Stephanie M.; Hammer, Joseph J.; Shetty, Dhanuraj; Timmer, Mark, Nonwoven tissue scaffold.
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  219. Kladakis, Stephanie M.; Hammer, Joseph J.; Shetty, Dhanuraj; Dhanaraj, Sridevi, Nonwoven tissue scaffold.
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  220. Kladakis, Stephanie M.; Hammer, Joseph J.; Shetty, Dhanuraj; Dhanaraj, Sridevi, Nonwoven tissue scaffold.
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  221. Griffey,Edward S.; Livesey,Stephen A.; Schiff,Charles M.; Boerboom,Lawrence E., Particulate acellular tissue matrix.
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  222. Bosley, Jr., Rodney W.; Fette, Clay; Tullius, Robert S., Particulate tissue graft with components of differing density and methods of making and using the same.
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  223. Bosley, Jr., Rodney W.; Fette, Clay; Tullius, Robert S., Particulate tissue graft with components of differing density and methods of making and using the same.
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  224. Bosley, Jr., Rodney W.; Fette, Clay; Tullius, Robert S., Particulate tissue graft with components of differing density and methods of making and using the same.
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  225. Bosley, Jr., Rodney W.; Fette, Clay; Tullius, Robert S., Particulate tissue graft with components of differing density and methods of making and using the same.
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  226. Paniagua, David; Fish, R. David, Percutaneous prosthetic heart valve.
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  227. Paniagua, David; Fish, R. David, Percutaneous replacement heart valve and a delivery and implantation system.
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  228. Fish, R. David; Paniagua, David, Percutaneously deliverable heart valve and methods associated therewith.
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  229. Fish, R. David; Induni, Eduaro; Paniagua, David, Percutaneously deliverable heart valve including folded membrane cusps with integral leaflets.
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  230. Paniagua, David; Fish, R. David, Percutaneously implantable replacement heart valve device and method of making same.
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  231. Paniagua, David; Fish, R. David; Induni, Eduardo; Meija, Carlos; Lopez-Jimenez, Fransisco, Percutaneously implantable replacement heart valve device and method of making same.
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  232. Paniagua, David; Induni, Eduardo; Fish, R. David, Percutaneously implantable replacement heart valve device and method of making same.
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  233. Paniagua, David; Induni, Eduardo; Mejia, Carlos; Lopez-Jimenez, Francisco; Fish, R. David, Percutaneously implantable replacement heart valve device and method of making same.
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  234. Paniagua, David; Induni, Eduardo; Mejia, Carlos; Lopez-Jimenez, Francisco; Fish, R. David, Percutaneously implantable replacement heart valve device and method of making same.
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  235. Wolfinbarger, Jr., Lloyd; O'Leary, Robert K.; Anderson, Billy G., Plasticized bone and soft tissue grafts and methods of making and using same.
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  236. Wolfinbarger, Jr., Lloyd; O'Leary, Robert K.; Anderson, Billy G., Plasticized bone and soft tissue grafts and methods of making and using same.
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  237. Wolfinbarger, Jr., Lloyd; O'Leary, Robert K.; Anderson, Billy G., Plasticized bone and soft tissue grafts and methods of making and using same.
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  238. Crouch,Katrina; Wolfinbarger,Lloyd; O'Leary,Robert; Ford,Louis, Plasticized bone grafts and methods of making and using same.
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  239. Kirsch Axel (Talstrasse 23 D70794 Filderstadt DEX), Post-surgery orthopedic covering.
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  240. Schneider,James R., Preserved implantable vessel derived from a human umbilical cord or placenta.
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  241. Mills, C. Randal; Bianchi, John R.; Roberts, Michael R.; Nataraj, Chandrasekaran, Process and apparatus for treating implants comprising soft tissue.
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  242. Wolfinbarger ; Jr. Lloyd, Process for cleaning large bone grafts and bone grafts produced thereby.
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  243. Wolfinbarger, Jr., Lloyd; Lange, Perry; Linhurst, Alyce; Moore, Eric; Nolf, Barry, Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced.
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  244. Wolfinbarger, Jr.,Lloyd; Lange,Perry; Linhurst Jones,Alyce; Moore,Eric; Nolf,Barry, Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced.
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  245. Wolfinbarger, Jr., Lloyd; Lange, Perry; Linhurst, Alyce; Moore, Eric; Nolf, Barry, Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced.
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  246. Wolfinbarger, Jr., Lloyd; Lange, Perry; Linthurst-Jones, Alyce; Moore, Eric; Nolf, Barry, Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced.
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  247. Wolfinbarger, Jr., Lloyd; Lange, Perry; Linthurst-Jones, Alyce; Moore, Eric; Nolf, Barry, Process for devitalizing soft-tissue engineered medical implants, and devitalized soft-tissue medical implants produced.
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  248. Everaerts, Frank J. L.; Torrianni, Mark W.; Everaerts, Frans M.; Trescony, Paul V.; den Hartog, Wilfred, Process for producing decellularized biological tissues.
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  249. Johnson, Chad E., Processed ECM materials with enhanced component profiles.
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  250. Johnson, Chad E., Processed ECM materials with enhanced component profiles.
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  251. Dai, Jianwu; Bell, Eugene; Russakovsky, Vladimir, Processing fetal or neo-natal tissue to produce a scaffold for tissue engineering.
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  252. Prewett Annamarie B. (Little Silver NJ) O\Leary Robert K. (Spring Lake NJ), Processing of fibrous connective tissue.
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  253. Dai,Jianwu; Bell,Eugene; Russakovsky,Vladimir, Processing tissue to produce a biopolymer scaffold for tissue engineering.
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  254. Stone Kevin R. (Mill Valley CA) Li Shu-Tung (Oakland NJ), Prosthetic articular cartilage.
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  255. Gregory Kenton W., Prosthetic devices including elastin or elastin-based materials.
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  256. Matheny, Robert G., Prosthetic tissue valve.
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  257. Matheny, Robert G., Prosthetic tissue valve.
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  258. Masters, David B., Protein biomaterial and biocoacervate vessel graft systems and methods of making and using thereof.
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  259. Masters, David B.; Berg, Eric P., Protein biomaterials and biocoacervates and methods of making and using thereof.
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  260. Masters, David B.; Berg, Eric P., Protein biomaterials and biocoacervates and methods of making and using thereof.
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  261. Masters, David B., Protein matrix materials, devices and methods of making and using thereof.
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  262. Masters, David B., Protein matrix materials, devices and methods of making and using thereof.
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  263. Kevin R. Stone, Proteoglycan-reduced soft tissue xenografts.
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  264. Stone Kevin R., Proteoglycan-reduced soft tissue xenografts.
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  265. Thorne, Kevin; Akella, Rama, Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue.
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  266. Yui Tooru,JPX ; Nakagawa Tokuzo,JPX ; Kondoh Kazuo,JPX, Raw membranous material for medical materials and manufacturing methods thereof.
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  267. Wolfinbarger ; Jr. Lloyd, Recirculation method for cleaning essentially intact bone grafts using pressure mediated flow of solutions and bone gra.
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  268. Bowman, Steven M.; Bruker, Izi; Rezania, Alireza, Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration.
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  269. Bowman, Steven M.; Bruker, Izi; Rezania, Alireza; Melican, Mora Carolynne; Binette, Francois; Hwang, Julia, Reinforced foam implants with enhanced integrity for soft tissue repair and regeneration.
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  270. Cox, James L., Replacement atrioventricular heart valve.
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  271. Cox, James L., Replacement atrioventricular heart valve.
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  272. Cox, James L., Replacement heart valve.
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  273. Cox, James, Replacement semilunar heart valve.
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  274. Cox, James L., Replacement semilunar heart valve.
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  275. Cox James L., Replacement semilunar heart valves using flexible tubes.
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  276. Cox James L., Replacement semilunar heart valves using flexible tubes.
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  277. Ferree, Bret A., Rotator cuff repair using engineered tissues.
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  278. Hwang, Julia; Hammer, Joseph; Schwartz, Herb; Malaviya, Prasanna, Scaffold for connective tissue repair.
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  279. Hwang, Julia; Hammer, Joseph; Schwartz, Herb; Malaviya, Prasanna, Scaffold for connective tissue repair.
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  280. Sigurjonsson, Gudmundur Fertram; Gisladottir, Dora Hlin; Gudmundsson, Gudmundur, Scaffold material for wound care and/or other tissue healing applications.
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  281. Janzen Ernst (Laren NLX) Hoekstra Matthias Johannes (Amstelveen NLX) Dutrieux Richard P. (Amsterdam NLX) Damink Leonardus Hermannus Hendrikus Olde (Vaals NLX), Soft tissue implant.
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  282. Janzen Ernst,NLX ; Hoekstra Matthias Johannes,NLX ; Dutrieux Richard P.,NLX ; Damink Leonardus Hermannus Hendrikus Olde,NLX, Soft tissue implant.
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  283. Stone, Kevin R.; Galili, Uri, Soft tissue xenografts.
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  284. Carlos M. G. Duran ; David T. Cheung ; David C. Pang, Solution and method for treating autologous tissue for implant operation.
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  285. Andrew W. Buirge ; Paul J. Buscemi ; Paul H. Burmeister, Stent with collagen.
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  286. Buirge Andrew W. (Minnepaolis MN) Buscemi Paul J. (Long Lake MN) Burmeister Paul H. (Maple Grove MN), Stent with collagen.
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  287. Drunecky, Tomas; Matouskova, Eva; Stehlicek, Petr; Stoy, Vladimir; Vesely, Pavel, Sterile autologous, allogenic or xenogenic implant and the method of its production.
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  288. Stephen F. Badylak ; Andrew O. Brightman ; Jason P. Hodde ; Timothy B. McPherson ; Sherry L. Voytik-Harbin, Submucosa extracts.
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  289. Badylak Stephen F. ; Voytik Sherry ; Boder George, Submucosa gel as a growth substrate for cells.
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  290. Stone Kevin R., Substantially native meniscal cartilage heterografts.
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  291. Love Charles S. ; Dahl Terrance J., System and method for assembling graft structures.
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  292. Dennis,Robert G.; Birla,Ravi K.; Boluyl,Marvin O.; Arruda,Ellen M.; Baar,Keith R.; Borschel,Gregory H., System and method for forming a cardiac muscle construct.
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  293. Kosnik,Paul E.; Dennis,Robert G.; Calve,Sarah C.; Arruda,Ellen M., System and method for forming a connective tissue construct.
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  294. Arruda, Ellen M.; Larkin, Lisa M.; Syed-Picard, Fatima N.; Smietana, Michael; Ma, Jinjin, System and method for forming bone, ligament, and bone-ligament constructs.
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  295. Arruda, Ellen M.; Larkin, Lisa M.; Syed-Picard, Fatima N.; Smietana, Michael; Ma, Jinjin, System and method for forming bone, ligament, and bone-ligament constructs.
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  296. Carranza,Jose R.; Donohoe,Brendan M.; Bender,Theodore M., System for preparing a craft vessel for anastomosis.
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  297. Carranza, Jose R.; Donohoe, Brendan M.; Bender, Theodore M.; Sherman, Benjamin, System for preparing a graft vessel for anastomosis.
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  298. Fishman, Robert; Havener, Robert; Fattah, Ihab Abdel; Abdelazim, Anas; Newell, Scott; Bishop, Tom; Khayal, Tamer; Kyi, Stanley; Taylor, Ron; Harriott, Doug; De Remer, Matthew; Murray, Paul; Sullivan, John; Anderson, Mark; Bringham, Richard; Van Driel, Michael; Hassanein, Waleed, Systems and methods for ex vivo lung care.
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  299. Hassanein, Waleed; Khayal, Tamer; Elbetanony, Ahmed; Lezberg, Paul; Cecere, Giovanni; Sousa, Dennis; Hansen, Elizabeth, Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status.
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  300. Hassanein, Waleed H.; Khayal, Tamer I.; Lezberg, Paul, Systems, methods, compositions and solutions for perfusing an organ.
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  301. Cooper, Kevin; Chun, Iksoo; Colter, David C.; Dhanaraj, Sridevi; Gosiewska, Anna; Seyda, Agnieszka; Fang, Carrie H.; Yang, Chunlin, Tissue engineered blood vessel.
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  302. Ollerenshaw, Jeremy D.; Goldstein, Steven; Black, Kirby S., Tissue graft.
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  303. Ollerenshaw, Jeremy D.; Goldstein, Steven; Black, Kirby S., Tissue graft.
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  304. Bosley, Jr., Rodney W.; Fette, Clay, Tissue graft composition.
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  305. Plouhar Pamela L. ; Dunn Michael D. ; Lower Jerry L. ; May Thomas C., Tissue graft construct for replacement of cartilaginous structures.
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  306. Simionescu,Dan T.; Vyavahare,Narendra, Tissue material and process for bioprosthesis.
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  307. Simionescu, Dan T.; Vyavahare, Narendra, Tissue material process for forming bioprosthesis.
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  308. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  309. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  310. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  311. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  312. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  313. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  314. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  315. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  316. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  317. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  318. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  319. Spievack, Alan R., Tissue regenerative composition, method of making, and method of use thereof.
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  320. Spievack, Alan R., Tissue regenerative compositions for cardiac applications, method of making, and method of use thereof.
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  321. Carr, Jr.,Robert M.; Condon,Kimberlie D.; Termin,Paul L.; Young,Janet Hardin, Tissue repair fabric.
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  322. Bonutti, Peter M., Tissue stabilizing implant method.
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  323. Fette, Clay, Tissue-based compositions.
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  324. Ferree, Bret A., Transplantation of engineered meniscus tissue to the intervertebral disc.
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  325. Goldstein Steven, Treated tissue for implantation and methods of preparation.
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  326. Goldstein Steven (Atlanta GA), Treated tissue for implantation and methods of preparation.
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