Baker Richard W. (Palo Alto CA) Ninomiya Yasuo (Ibaraki
Osaka JPX)
출원인 / 주소
Bend Research, Inc. (Bend OR 02)
인용정보
피인용 횟수 :
24인용 특허 :
2
초록▼
There is disclosed an improved complex coacervation process for microencapsulation of core ingredients that are partially soluble in the microcapsule walls wherein the core ingredient is first mixed with a coacervation adjacent prior to forming a first colloidal emulsion of core ingredient, and, aft
There is disclosed an improved complex coacervation process for microencapsulation of core ingredients that are partially soluble in the microcapsule walls wherein the core ingredient is first mixed with a coacervation adjacent prior to forming a first colloidal emulsion of core ingredient, and, after combining the first emulsion with a second colloidal solution and cooling to cause gelation, a water-soluble wax derivative is added. No pH adjustment or dilution is necessary, and very high yields of non-agglomerated microcapsules are obtained, both in terms of quantity of microcapsules and content of core ingredient. When deet is the core ingredient there is obtained a long-lasting mosquito repellent.
대표청구항▼
In a complex coacervation process for microencapsulating a core ingredient that is partially soluble in the walls of microcapsules comprising the steps of (a) forming an emulsion of said core ingredient in an aqueous solution of a first ionizable colloid, (b) forming an aqueous solution of a second
In a complex coacervation process for microencapsulating a core ingredient that is partially soluble in the walls of microcapsules comprising the steps of (a) forming an emulsion of said core ingredient in an aqueous solution of a first ionizable colloid, (b) forming an aqueous solution of a second ionizable colloid of opposite electrical charge to that of said first ionizable colloid, (c) forming a mixture by combining the emulsion of step (a) with the aqueous solution of step (b), (d) cooling said mixture of step (c) to cause gelation of microcapsule walls around droplets of said core ingredient, and (e) hardening said microcapsule walls, the improvement comprising the steps of (1) forming a coacervation adjuvant/core ingredient mixture prior to step (a) by mixing with said core ingredient a coacervation adjuvant selected from the group consisting of an ionizable colloid, an ionic surfactant and an ionizable long-chain organic compound, (2) substituting the coacervation adjuvant/core ingredient mixture formed in step (1) for the core ingredient of step (a), and (3) between steps (d) and (e), adding from 5 to 20% by weight of a water-soluble wax derivative selected from the group consisting of derivatives of any of lanolin, carnauba, beeswax, paraffin, polyether-esters and chlorinated naphthalenes, all of said steps being conducted without pH adjustment, without the addition of an inorganic salt, without dilution, and without phase inversion. A long-lasting mosquito repellent composition comprising a pharmaceutically acceptable vehicle and microcapsules, said microcapsules being made by, in the following order, the steps of (a) forming a coacervation adjuvant/mosquito repellent mixture by mixing a coacervation adjuvant selected from the group consisting of an ionizable colloid, an ionic surfactant and an ionizable long-chain organic compound with a mosquito repellent, (b) forming an emulsion by emulsifying said coacervation adjuvant/mosquito repellent mixture in an aqueous solution of a first ionizable colloid selected from the group consisting of gelatin, gum arabic, gum karaya, gum tragacanth, casein, carrageenan, and carboxymethylcellulose, (c) forming an aqueous solution of a second ionizable colloid of opposite electrical charge to that of the first ionizable colloid, said second ionizable colloid being selected from the group consisting of gelatin, gum arabic, casein, carrageenan, and carboxymethylcellulose, (d) forming a mixture by combining the emulsion of step (b) with the aqueous solution of step (c), (e) cooling said mixture of step (d) to cause gelation of microcapsule walls around droplets of said mosquito repellent, (f) adding to said cooled mixture of step (e) from 5 to 20% by weight of a water-soluble wax derivative selected from the group consisting of derivatives of any of lanolin, carnauba, beeswax, paraffin, polyether-esters and chlorinated naphthalenes, and (g) hardening said microcapsules walls, all of said steps being conducted without pH adjustment, without the addition of an inorganic salt, without dilution, and without phase inversion.
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이 특허에 인용된 특허 (2)
McGovern Terrence P. (Bowie MD) Schreck Carl E. (Gainesville FL), Insect repellents.
Curtis, Jonathan Michael; Zhang, Wei; Spurvey, Sharon Ann; Robert, Suzelle Rejeanne, Homogenized formulations containing microcapsules and methods of making and using thereof.
Curtis, Jonathan Michael; Zhang, Wei; Jin, Yulai; Barrow, Colin James, Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof.
Sutton Andrew D.,GBX ; Johnson Richard A.,GBX ; Senior Peter J.,GBX ; Heath David,GBX, Spray-dried microparticles and their use as therapeutic vehicles.
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