초록 ▼

Providing a water slurry containing an immobilizing agent and an insoluble substance, such as calcium citrate, effective to cause gelation of the immobilizing agent. The water slurry is then contacted with a hydrophobic liquid, such as a vegetable oil under conditions leading to the formation of a d

Providing a water slurry containing an immobilizing agent and an insoluble substance, such as calcium citrate, effective to cause gelation of the immobilizing agent. The water slurry is then contacted with a hydrophobic liquid, such as a vegetable oil under conditions leading to the formation of a dispersion of droplets of the water slurry in the hydrophobic liquid. The droplets gel to form microspheres by adding an oil-soluble organic acid, such as acetic acid to the dispersion containing the droplets. Possibility of producing microspheres which are very small and are constituted of nearly perfect spheres. If desired the method can be adapted to produce microspheres containing immobilized material.

대표청구항 ▼

Method for the production of microspheres which comprises a) providing a water slurry containing an immobilizing agent and a substance effective to cause gelation of said immobilizing agent, b) contacting said water slurry with a hydrophobic liquid under conditions leading to formation of droplets o

Method for the production of microspheres which comprises a) providing a water slurry containing an immobilizing agent and a substance effective to cause gelation of said immobilizing agent, b) contacting said water slurry with a hydrophobic liquid under conditions leading to formation of droplets of said water slurry in said hydrophobic liquid, and c) adding an oil soluble organic acid to mixture obtained in step b to convert said droplets into solid microspheres. Method according to claim 1, which comprises adding a pH adjusting compound to said water slurry. Method according to claim 9, wherein said pH adjusting compound is selected from the group consisting of sodium citrate, disodium phosphate and potassium citrate. Method according to claim 11, which comprises storing microspheres obtained in step c in a microsphere storage solution to maintain solid microspheres.