초록 ▼

A vaginal ring comprises a supporting ring 1 free of active agent. A layer 2, which contains an active agent such as a steroid, is applied on its outer rim, optionally in a continuous groove provided in the supporting ring. This layer, in turn, is coated with a layer 3 devoid of active ingredient. A

A vaginal ring comprises a supporting ring 1 free of active agent. A layer 2, which contains an active agent such as a steroid, is applied on its outer rim, optionally in a continuous groove provided in the supporting ring. This layer, in turn, is coated with a layer 3 devoid of active ingredient. All components preferably comprise an LTV silicone elastomer. The ratio of the thickness of the layer 2, containing an active agent, to the layer 3, free of active agent, is about 5-50:1. As a result, a long-term and uniform release rate is achieved for the active agent.

대표청구항 ▼

A vaginal ring spaced from an axis of revolution, the ring having an inside diameter and an outside diameter, a radial thickness with respect to the axis and an axial thickness in the direction of the axis, the ring having first and second exposed radial surfaces and the ring further comprising: a s

A vaginal ring spaced from an axis of revolution, the ring having an inside diameter and an outside diameter, a radial thickness with respect to the axis and an axial thickness in the direction of the axis, the ring having first and second exposed radial surfaces and the ring further comprising: a supporting ring made of a pharmacologically acceptable material and being essentially free of medicament; the supporting ring having a first annular surface between inner and outer circumferential peripheries extending in a radial direction and generally facing in a first axial direction, the supporting ring having a second annular surface extending in a radial direction with respect to the axis and facing in an axial direction opposite that of the first annular surface, the second annular surface being completely exposed; a first annular layer made of a pharmacologically acceptable material and containing a pharmacologically active agent, the first annular layer extending in the axial direction and overlying radially the first annular surface of the supporting ring between the inner and outer circumferential peripheries thereof; and a second pharmacologically acceptable layer overlying the first annular layer in the axial direction; said second layer being essentially medicament free and being permeable to the active agent in the first layer; said second layer being thinner than the first layer in a ratio of 5-50:1, and also being in contact with the supporting layer at the inner and outer circumferential peripheries of the supporting layer, the second pharmacologically acceptable layer controlling the rate of migration of the activation from the first layer into the vagina.