초록 ▼

A polyorganosiloxane composition having a biocompatible surface thereon is disclosed. The biocompatible surface results from the derivatization, or amination, of the surface intended for cell contact. More specifically, the present invention is a polyorganosiloxane composition in which the surface i

A polyorganosiloxane composition having a biocompatible surface thereon is disclosed. The biocompatible surface results from the derivatization, or amination, of the surface intended for cell contact. More specifically, the present invention is a polyorganosiloxane composition in which the surface is either treated with a primary amine and optional peptide or the surface is co-cured with a primary amine-containing silane or siloxane. The aminated polyorganosiloxane has utility as a cell culture substrate or in a variety of artificial organ applicatons such as breast implants, synthetic blood vessels, joints, tendons and heart valves. A vacuum apparatus for use with specialized cell cultrue plates incorporating the biocompatible polyorganosiloxane composition is also disclosed.

대표청구항 ▼

A method for treating the surface of a polyorganosiloxane composition comprising the steps of: (a) contacting the polyorganosiloxane surface with an acid selected from the group consisting of hydrochloric acid, hydrofluoric acid and hydrobromic acid and then decanting said acid; (b) contacting the p

A method for treating the surface of a polyorganosiloxane composition comprising the steps of: (a) contacting the polyorganosiloxane surface with an acid selected from the group consisting of hydrochloric acid, hydrofluoric acid and hydrobromic acid and then decanting said acid; (b) contacting the polyorganosiloxane surface with an amine selected from the group consisting of ammonium hydroxide, ammonium chloride and ammonium bicarbonate and then decanting said amine; and (c) washing said polyorganosiloxane surface with water.