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Monoclonal antibody specific for DNA.RNA hybrids

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-005/00
  • C07K-015/06
  • C12Q-001/68
  • C12P-021/00
출원번호 US-0769022 (1985-08-26)
발명자 / 주소
  • Carrico Robert J. (Elkhart IN)
출원인 / 주소
  • Miles Inc. (Elkhart IN 02)
인용정보 피인용 횟수 : 32  인용 특허 : 4

초록

A monoclonal antibody specific for DNAㆍRNA duplexes, particularly DNAㆍRNA heteropolymer duplexes, characterized by having cross-reactivity for binding to single- or double-stranded DNA or RNA as measured by competitive immunoassay of less than about 1:1000, and preferably less than 1:10,000, and an

대표청구항

The monoclonal antibody secreted by hybridoma cell line ATCC HB 8730.

이 특허에 인용된 특허 (4)

  1. Carrico Robert J. (Elkhart IN), Hybridization assay employing labeled probe and anti-hybrid.
  2. David Gary S. (La Jolla CA) Greene Howard E. (Carlsbad CA), Immunometric assays using monoclonal antibodies.
  3. Stuart W. Dorsey (Honolulu HI) Frank Mark B. (Irvine CA), Monoclonal antibodies for DNA-RNA hybrid complexes and their uses.
  4. Falkow Stanley (Seattle WA) Moseley Stephen L. (Kirkland WA), Specific DNA probes in diagnostic microbiology.

이 특허를 인용한 특허 (32)

  1. Hyldig-Nielsen Jens J. (Vanlse DKX) Pluzek Karl-Johan (Smoerum DKX), Antibody to PNA/nucleic acid complexes.
  2. Lorincz, Attila T.; Lazar, James G., Assessment of human papilloma virus-related disease.
  3. Liu, Shubing; Ramachandran, Suganthi, Compositions and methods for recovery of nucleic acids or proteins from tissue samples fixed in cytology media.
  4. Holmes, Eric H.; Greene, Thomas G., Detection and quantitation of 8-OH-adenine using monoclonal antibodies.
  5. Garcia Mariana ; Chan Ming ; Lorincz Attila, Detection of hepatitis B virus.
  6. Anthony, James; Lorincz, Attila; Troy, John; Tan, Yanglin, Detection of nucleic acids by target-specific hybrid capture method.
  7. Nazarenko, Irina; Lorincz, Attila; Eder, Paul; Lowe, Brian; Mallonee, Richard; Thai, Ha, Detection of nucleic acids by target-specific hybrid capture method.
  8. Nazarenko, Irina; Lorincz, Attila; Eder, Paul; Lowe, Brian; Mallonee, Richard; Thai, Ha, Detection of nucleic acids by target-specific hybrid capture method.
  9. Nazarenko, Irina; Lorincz, Attila; Eder, Paul; Lowe, Brian; Mallonee, Richard; Thai, Ha, Detection of nucleic acids by target-specific hybrid capture method.
  10. Anthony, James; Lorincz, Attila; Troy, John; Tan, Yanglin, Detection of nucleic acids by type specific hybrid capture method.
  11. Anthony, James; Lorincz, Attila; Williams, Inna; Troy, John; Tang, Yanlin, Detection of nucleic acids by type-specific hybrid capture method.
  12. Anthony, James; Lorincz, Attila; Williams, Inna; Troy, John; Tang, Yanlin, Detection of nucleic acids by type-specific hybrid capture method.
  13. Anthony,James; Lorincz,Attila; Troy,John; Tan,Yanglin, Detection of nucleic acids by type-specific hybrid capture method.
  14. De La Rosa Abel ; Collier Clayton D., Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function.
  15. Lazar James G. ; De La Rosa Abel ; Collier Clayton D., Direct detection of RNA mediated by reverse transcriptase lacking RNAse H function.
  16. Eder, Paul; Payne, Eric; Nazarenko, Irina; Ramachandran, Suganthi; Virmani, Arvind; Bell, Laura, Fast results hybrid capture assay and system.
  17. Eder, Paul; Payne, Eric; Nazarenko, Irina; Ramachandran, Suganthi; Virmani, Arvind; Bell, Laura, Fast results hybrid capture assay and system.
  18. Eder, Paul; Payne, Eric; Nazarenko, Irina; Ramachandran, Suganthi; Virmani, Arvind; Bell, Laura, Fast results hybrid capture assay on an automated platform.
  19. Sivaraja Mohanram ; Strulovici Berta ; Flores Osvaldo A., High throughput in vitro screening assays for transcription modulators.
  20. Stuart Harbron GB, Hybridization assay for detecting a single-stranded target nucleic acid in which excess probe is destroyed.
  21. Lazar, James G.; Zakel, Joan M.; Strange, Christina M.; Williams, Inna R.; Lorincz, Attila T.; De La Rosa, Abel, Immunological detection of RNA:DNA hybrids on microarrays.
  22. Lazar,James G.; Zakel,Joan M.; Strange,Christina M.; Williams,Inna R.; Lorincz,Attila T.; De La Rosa,Abel, Immunological detection of RNA:DNA hybrids on microarrays.
  23. Fredriksson, Simon, Kit for proximity probing with multivalent proximity probes.
  24. Lowe, Brian; Fulbright, Anna K.; Nazarenko, Irina, Materials and methods for detection of HPV nucleic acids.
  25. Fulton R. Jerrold, Method and compositions for flow cytometric determination of DNA sequences.
  26. Nazarenko, Irina, Method of determining and confirming the presence of an HPV in a sample.
  27. O'Neil, Dominic; Nazarenko, Irina; Basham, Holly; Virmani, Arvind; Agarwal, Shiuli; Shukla, Mridula, Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids.
  28. Rothmann, Thomas; Nazarenko, Irina; O'Neil, Dominic; Virmani, Arvind; Lowe, Brian; Agarwal, Shiuli; Basham, Holly, Methods and compositions for sequence-specific purification and multiplex analysis of nucleic acids.
  29. Linsley Peter S. ; Baeuerle Patrick,DEX, Monitoring of gene expression by detecting hybridization to nucleic acid arrays using anti-heteronucleic acid antibodies.
  30. Impraim Chaka ; Challberg Sharon ; Lorincz Attila ; Cullen Allison, Non-radioactive hybridization assay and kit.
  31. Lowe, Brian; Fulbright, Anna K.; Nazarenko, Irina, Non-target amplification method for detection of RNA splice-forms in a sample.
  32. Pontius Brian Wylie, Promotion of high specificity molecular assembly.
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