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Polypeptide cartilage-inducing factors found in bone 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07G-007/00
  • A61K-009/00
출원번호 US-0204173 (1988-06-08)
발명자 / 주소
  • Seyedin Saeid (Sunnyvale CA) Thomas Thomas (Davis CA) Bentz Hanne (Palo Alto CA) Ellingsworth Larry (San Jose CA) Armstrong Rosa (Palo Alto CA)
출원인 / 주소
  • Collagen Corporation (Palo Alto CA 02)
인용정보 피인용 횟수 : 93  인용 특허 : 5

초록 ▼

Two proteins that are found in bone and that have in vivo chondrogenic/osteogenic activity in combination with a co-factor are described. Both proteins also were active in combination with EGF in the in vitro TGF-bbb

대표청구항 ▼

A method of promoting proliferation of cells in an animal comprising administering to the animal a composition comprising a TGF-beta activating agent, a pharmaceutically acceptable carrier, and a polypeptide that (a) is found in mammalian bone, (b) is active in the TGF-beta assay, (c) is a co-factor

이 특허에 인용된 특허 (5)

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  5. Seyedin Saeid (Mt. View CA) Thomas Thomas (Palo Alto CA), Partially purified osteogenic factor and process for preparing same from demineralized bone.
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