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Conjugation of polymer to colony stimulating factor-1 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C08L-089/00
  • C07G-007/00
  • A61K-037/02
출원번호 US-0146275 (1988-01-20)
발명자 / 주소
  • Shadle Paula J. (Richmond CA) Koths Kirston E. (El Cerrito CA) Moreland Margaret (Berkeley CA) Katre Nandini (El Cerrito CA)
출원인 / 주소
  • Cetus Corporation (Emeryville CA 02)
인용정보 피인용 횟수 : 180  인용 특허 : 17

초록 ▼

A biologically active CSF-1 protein is selectively conjugated via certain amino acid residues or carbohydrate moieties to a water-soluble polymer selected from polyethylene glycol or polypropylene glycol homopolymers, polyoxyethylated polyols, or polyvinyl alcohol. The resulting conjugated CSF-1 is

대표청구항 ▼

A biologically active composition comprising a protein that stimulates the formation of primarily macrophage colonies in the in vitro colony stimulating factor-1 (CSF-1) assay, which protein is covalently conjugated to a water-soluble polymer selected from the group consisting of polyethylene or pol

이 특허에 인용된 특허 (17)

  1. Lee Weng Y. (Winnipeg CAX) Sehon Alec (Winnipeg CAX), Allergen-containing substances.
    상세보기
  2. Iwashita Yuji (Kawasaki JPX) Ajisaka Katsumi (Yokohama JPX), Blood substitute containing modified hemoglobin.
    상세보기
  3. Mitra Gautam (Kensington CA), Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer.
    상세보기
  4. Green Joseph (London EN) Cawthorne Michael Anthony (Horsham EN), Fibrinolytic compositions.
    상세보기
  5. Yamamura Yuichi (Takarazuka JPX) Kishimoto Tadamitsu (Tondabayashi JPX) Nakai Satoru (Tokushima JPX) Hirai Yoshikatsu (Tokushima JPX), Human cultured cell line.
    상세보기
  6. Nicolson Margery (Pacific Palisades CA), Hybridoma tumor cell lines and their monoclonal antibodies to human colony stimulating factor subclass number 1.
    상세보기
  7. Hiratani Hajime (Sennan JPX), Long-acting composition.
    상세보기
  8. Mosbach Klaus H. (Furulund SEX) Nilsson Kurt G. I. (Lund SEX), Method of covalently binding biologically active organic substances to polymeric substances.
    상세보기
  9. Funakoshi Satoshi (Katano JPX) Morimoto Kazuo (Fukuchiyama JPX) Kuboyama Morio (Tokyo JPX) Yanai Nobuya (Tokyo JPX) Yamada Muneo (Kawasaki JPX) Yokota Hajime (Tokyo JPX), Method of preparation of human urine origin colony-stimulating factor and kallikrein.
    상세보기
  10. Royer Garfield P. (Worthington OH), Modifying enzymes with polyethylene glycol and product produced thereby.
    상세보기
  11. Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
    상세보기
  12. Lee Weng Y. (95 Rochester Pl. Winnipeg CAX) Sehon Alec (695 Academy Rd. Winnipeg CAX R3N OE8), Penicillin-polyvinyl alcohol conjugate and process of preparation.
    상세보기
  13. Bayer Ernst (Tubingen DT) Mutter Manfred (Tubingen DT), Polyalkylene glycols used for the preparation of peptides.
    상세보기
  14. Sugimoto Kaname (Okayama JPX), Process for the production of human colony-stimulating factor.
    상세보기
  15. Schneider ; Michel, Reversibly precipitable immobilized enzyme complex and a method for its use.
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  16. Katre Nandini (El Cerrito CA) Knauf Michael J. (Oakland CA), Solubilization of proteins for pharmaceutical compositions using polymer conjugation.
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  17. Lee Weng Y. (99 Silver Ridge Rise NW. Calgary ; Alberta CAX T3B 4P6) Sehon Alec (695 Academy Rd. Winnipeg ; Manitoba CAX R3N 0E8), Suppression of reaginic antibodies to drugs employing polyvinyl alcohol as carrier therefor.
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