초록 ▼

Liquid, controlled release formulations are provided by emulisifying an aqueous active ingredient-polymer complex, an organic solution of a film-forming polymer and an organic solvent, and a surfactant to form a first emulsion. An aqueous solution of a surfactant is emulsified with the first emulsio

Liquid, controlled release formulations are provided by emulisifying an aqueous active ingredient-polymer complex, an organic solution of a film-forming polymer and an organic solvent, and a surfactant to form a first emulsion. An aqueous solution of a surfactant is emulsified with the first emulsion to produce a second emulsion and the organic solvent is subsequently removed to produce a liquid controlled release formulation. The formulation so produced includes an aqueous dispersion of microcapsules having permeable shells of the film-forming polymer and aqueous cores of the aqueous active ingredient-polymer complex.

대표청구항 ▼

A method for preparing a liquid controlled release dosage formulation, comprising the steps of: preparing an aqueous solution of an active ingredient and a complex-forming polymer to produce active ingredient-polymer complexes; preparing an organic solution of a film-forming polymer in an organic so

A method for preparing a liquid controlled release dosage formulation, comprising the steps of: preparing an aqueous solution of an active ingredient and a complex-forming polymer to produce active ingredient-polymer complexes; preparing an organic solution of a film-forming polymer in an organic solvent; adding a first surfactant to said aqueous solution of to said organic solution or to both solutions; emulsifying said solutions to produce an aqueous-organic first emulsion; preparing an aqueous solution of a second surfactant; emulsifying said aqueous solution of said second surfactant with said first emulsion to produce an aqueous-organic-aqueous second emulsion; and removing said organic solvent from the second emulsion to produce an aqueous dispersion of microcapsules each having a permeable polymeric shell of said film-forming polymer encapsulating an aqueous core of active ingredient-polymer complexes.