[특허]Preparation of multiwall polymeric microcapsules

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Preparation of multiwall polymeric microcapsules 원문보기

IPC분류정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	A61K-009/56 A61K-009/58 B01J-013/02
출원번호	US-0045840 (1987-05-01)
발명자 / 주소	Mathiowitz Edith (Brookline MA) Langer Robert S. (Somerville MA)
출원인 / 주소	Massachusetts Institute of Technology (Cambridge MA 02)
인용정보	피인용 횟수 : 245 인용 특허 : 4

초록 ▼

A single step method for preparation of multi-layer polymeric delivery systems. Any two or three different degradable or non-degradable polymers which are not soluble in each other at a particular concentration, as dictated by their phase diagram, can be used. The multi-layer microcapsules produced by the method are distinguished by extremely uniform dimensioned layers of polymer and actual incorporation of the substance to be delivered into the polymer layers. In the preferred embodiment of the method, two polymers are dissolved in a volatile organic solvent, the substance to be encapsulated is dispersed or dissolved in the polymer solution, the mixture is suspended in an aqueous solution and stirred, and the solvent is slowly evaporated, creating microspheres with an inner core formed by one polymer and an outer layer formed by the second polymer. In another embodiment one polymer may be formed within a layer of the other polymer by increasing the rate of evaporation of the volatile solvent.

대표청구항 ▼

A method for forming multi-layered polymeric microcapsules comprising: selecting first and second polymers, wherein the polymers are selected from the group consisting of polyanhydrides, polyorthoesters, polylactic acid, polystyrene, polyamides, ethylene vinyl acetate, polybutadiene, polyurethanes, and copolymers and combinations thereof, to form microcapsules; selecting a substance to be incorporated into said microcapsules; dissolving said polymers in a volatile solvent; adding the substance to the polymer solution; mixing the polymer and substance solution; suspending the polymer substance mixture in a nonsolvent wherein said polymers separate into distinct phases; and evaporating the volatile solvent to form microcapsules having at least one distinct polymer layer around a polymer core. The method of claim 1 further comprising forming additional polymer layers around said microcapsules.

이 특허에 인용된 특허 (4)

Wellman Russel E. (Pittsford NY) Brown Robert W. (Rochester NY), Encapsulation process.
상세보기
Jaffe Howard (Gaithersburg MD), Microencapsulation process.
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Morishita Masataka (Shizuoka JA) Inaba Yoshihito (Shizuoka JA) Fukushima Mitsuru (Shizuoka JA) Hattori Yoshinori (Shizuoka JA) Kobari Sadami (Shizuoka JA) Matsuda Tetsuo (Shizuoka JA), Process for encapsulation of medicaments.
상세보기
Gardner David L. (Bellville OH), Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or e 상세보기

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Berde Charles B. ; Langer Robert S. ; Curley Joanne ; Castillo Jenny, High load formulations and methods for providing prolonged local anesthesia.
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Berde Charles B. ; Langer Robert S. ; Curley Joanne ; Castillo Jenny, High load formulations and methods for providing prolonged local anesthesia.
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Borodic, Gary E., High-potency botulinum toxin formulations.
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Borodic, Gary E., High-potency botulinum toxin formulations.
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Curtis, Jonathan Michael; Zhang, Wei; Spurvey, Sharon Ann; Robert, Suzelle Rejeanne, Homogenized formulations containing microcapsules and methods of making and using thereof.
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Norchi, Terrence; Kates, Steven; Ellis-Behnke, Rutledge, Implantable meshes for controlling the movement of fluids.
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Norchi, Terrence; Kates, Steven; Ellis-Behnke, Rutledge, Implantable meshes for controlling the movement of fluids.
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Patel, Rajesh A.; Bucalo, Louis R.; Costantini, Lauren; Kleppner, Sofie, Implantable polymeric device for sustained release of dopamine agonist.
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Patel, Rajesh A.; Bucalo, Louis R.; Costantini, Lauren; Kleppner, Sofie, Implantable polymeric device for sustained release of dopamine agonist.
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Hokenson, Mark; Oberg, Keith A., Increasing drug affinity for crystalline microparticle surfaces.
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Smutney, Chad C.; Leone-Bay, Andrea; Galarza, Jose M.; Munoz, Hector; Martin, George R.; Grant, Marshall L., Inhalable vaccine compositions and methods.
상세보기
Poole, Trent; Steiner, Solomon S., Inhalation apparatus.
상세보기
Chou, Kang-Jye; Guo, Hong; Ashton, Paul; Shimizu, Robert W.; Watson, David A., Injectable sustained release delivery devices.
상세보기
Steiner, Solomon S.; Pohl, Roderike; Li, Ming; Hauser, Robert, Insulin formulations for rapid uptake.
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Overfield, Dennis; Sahi, Carl R.; Adamo, Benoit; Kinsey, P. Spencer; McLean, Scott; Polidoro, John M.; Smutney, Chad C., Interactive apparatus and method for real-time profiling of inhalation efforts.
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Yewey Gerald L. ; Krinick Nancy L. ; Dunn Richard L. ; Radomsky Michael L. ; Brouwer Gerbrand ; Tipton Arthur J., Liquid delivery compositions.
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Yewey Gerald L. ; Krinick Nancy L. ; Dunn Richard L. ; Radomsky Michael L. ; Brouwer Gerbrand ; Tipton Arthur J., Liquid delivery compositions.
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Yewey Gerald L. ; Krinick Nancy L. ; Dunn Richard L. ; Radomsky Michael L. ; Brouwer Gerbrand ; Tipton Arthur J., Liquid delivery compositions.
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Shao Wen (Baltimore MD) Leong Kam W. (Ellicott City MD), Living cells microencapsulated in a polymeric membrane having two layers.
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Brem, Henry; Mangraviti, Antonella; Olivi, Alessandro; Tyler, Betty M.; Raghavan, Tula, Local delivery forms of acriflavine for treating tumors.
상세보기
Haik, Yousef; Chen, Ching-Jen, Magnetic particle composition for therapeutic hyperthermia.
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Walls, John E.; Putt, Jeffrey W.; DeLine, Kenneth E., Material encapsulation system.
상세보기
Leone-Bay, Andrea; Stowell, Grayson W.; Guarneri, Joseph J.; Carlson, Dawn M.; Grant, Marshall; Smutney, Chad C., Method and composition for treating migraines.
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Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W., Method for delivery of monomeric or dimeric insulin complexed to diketopiperazine microparticles.
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Solomon S. Steiner ; Robert Feldstein ; Huiling Lian ; Christopher A. Rhodes ; Gregory S. Shen, Method for drug delivery to the pulmonary system.
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Steiner, Solomon S.; Feldstein, Robert; Lian, Huiling; Rhodes, Christopher A.; Shen, Gregory S., Method for drug delivery to the pulmonary system.
상세보기
Mathiowitz Edith ; Jong Yong S. ; Carino Gerardo ; Jacob Jules S., Method for gene therapy using nucleic acid loaded polymeric microparticles.
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Mathiowitz, Edith; Jong, Yong S.; Carino, Gerardo; Jacob, Jules S., Method for gene therapy using nucleic acid loaded polymeric microparticles.
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Wilson, Bryan R.; Grant, Marshall, Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent.
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Wilson, Bryan R.; Grant, Marshall, Method for improving the pharmaceutic properties of microparticles comprising diketopiperazine and an active agent.
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Chenite Abdellatif,CAX ; Selmani Amine,CAX, Method for preparation of polymer microparticles free of organic solvent traces.
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Chao Hung Ya, Method for producing microencapsulated adhesive.
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Asano, Itaru; Echigo, Yuji; Takezaki, Hiroshi, Method for producing polymer fine particle comprising contacting an emulsion with a poor solvent.
상세보기
Ashton, Paul, Method for treating and/or preventing retinal diseases with sustained release corticosteroids.
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Hokenson, Mark; Oberg, Keith A., Method of drug formulation.
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Oberg, Keith A.; Sulner, Joseph; Grant, Marshall L., Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents.
상세보기
Oberg, Keith A.; Sulner, Joseph; Grant, Marshall L., Method of drug formulation based on increasing the affinity of crystalline microparticle surfaces for active agents.
상세보기
Kvitnitsky, Emma; Shapiro, Yury; Privalov, Olga; Oleinik, Irena; Polisher, Igor, Method of microencapsulation.
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Asano, Itaru; Echigo, Yuji; Takezaki, Hiroshi, Method of producing fine particles of non-vinyl thermoplastic polymer.
상세보기
Richardson, Peter; Baughman, Robert A.; Potocka, Elizabeth; Boss, Anders Hasager; Petrucci, Richard, Method of treating diabetes type 2 by administering ultrarapid acting insulin.
상세보기
Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W., Methods and compositions for delivering peptides.
상세보기
Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W., Methods and compositions for delivering peptides.
상세보기
Jacob Jules S. ; Mathiowitz Edith, Methods and compositions for enhancing the bioadhesive properties of polymers.
상세보기
Jacob Jules S. ; Mathiowitz Edith, Methods and compositions for enhancing the bioadhesive properties of polymers.
상세보기
Jules S. Jacob ; Edith Mathiowitz, Methods and compositions for enhancing the bioadhesive properties of polymers.
상세보기
Santos Camila A. ; Jacob Jules S. ; Hertzog Benjamin A. ; Carino Gerardo P. ; Mathiowitz Edith, Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients.
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Santos Camila A. ; Jacob Jules S. ; Hertzog Benjamin A. ; Carino Gerardo P. ; Mathiowitz Edith, Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients.
상세보기
Patton, John S.; Foster, Linda S.; Platz, Robert M., Methods and compositions for pulmonary delivery of insulin.
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Langermann, Solomon; Liu, Linda, Methods and compositions for the inhibition of transplant rejection.
상세보기
Leone-Bay, Andrea; Houghten, Richard A.; Guarneri, Joseph J.; Stowell, Grayson W., Methods and compositions for treating pain.
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Leone-Bay, Andrea; Houghten, Richard A.; Guarneri, Joseph J.; Stowell, Grayson W., Methods and compositions for treating pain.
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Leone-Bay, Andrea; Houghten, Richard A.; Guarneri, Joseph J.; Stowell, Grayson W., Methods and compositions for treating pain.
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Dong, Haidong; Kwon, Eugene D.; Markovic, Svetomir N.; Krco, Christopher J., Methods and materials for treating cancer.
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Brown, Larry; McGeehan, John K.; Rashba-Step, Julia; Scott, Terrence L., Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation.
상세보기
McCarty, Neal; Thompson, Christopher H.; Kubanek, Julia, Methods for inhibiting CLC-2 channel with GATX2.
상세보기
Mathiowitz, Edith; Thanos, Christopher; Liu, Zhi, Methods for micronization of hydrophobic drugs.
상세보기
Sackler, Richard S.; Goldenheim, Paul D.; Chasin, Mark; Burch, Ronald M.; Reder, Robert F.; Tigner, Joseph, Methods for providing safe local anesthesia.
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Dong, Haidong; Harrington, Susan M.; Kwon, Eugene D.; Krco, Christopher J.; Liu, Xin, Methods for treating cancer in patients with elevated levels of BIM.
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Baker Keith ; Kieras Mark ; Redmon Martin ; Pratt Daniel, Methods for universally distributing therapeutic agents to the brain.
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Darvari, Ramin; Lambert, Adam; Rashba-Step, Julia E.; Yang, Mark X.; Zhang, Junhong; O'Connell, Ed, Methods of processing compositions containing microparticles.
상세보기
Piran, Uri; Mehr, Eugene; Brown, Larry R.; McGeehan, John K.; O'Connell, Ed, Methods of processing compositions containing microparticles.
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Piran, Uri, Methods of processing multi-phasic dispersions.
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Pardoll, Drew M.; Tsuchiya, Haruo; Gorski, Kevin S.; Tseng, Su-Yi, Methods of using B7-DC molecules to induce or enhance an immune response.
상세보기
Curtis, Jonathan Michael; Zhang, Wei; Jin, Yulai, Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof.
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Curtis, Jonathan Michael; Zhang, Wei; Jin, Yulai; Barrow, Colin James, Microcapsules and emulsions containing low bloom gelatin and methods of making and using thereof.
상세보기
Yan, Nianxi; Jin, Yulai, Microcapsules having multiple shells and method for the preparation thereof.
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Yulai, Jin; Barrow, Colin James; Zhang, Wei; Yan, Cuie; Curtis, Jonathan Michael; Moulton, Shawn; Djogbenou, Nancy Beatrice; Demont, Lesek Alexa, Microcapsules with improved shells.
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Hung Ya Chao, Microencapsulated adhesive.
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Chatterjee,Jhunu; Haik,Yousef; Chen,Ching Jen, Microencapsulation of magnetic material using heat stabilization.
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Kim, Kyekyoon; Choi, Hyungsoo; Choy, Young Bin, Microparticles.
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Kim,Kyekyoon; Choi,Hyungsoo; Choy,Young Bin, Microparticles.
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Steiner Solomon S. ; Feldstein Robert ; Lian Huiling ; Rhodes Christopher A. ; Shen Gregory S., Microparticles for lung delivery comprising diketopiperazine.
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Brown, Larry R.; Giannoukakis, Nick; Gillis, Kimberly A.; Trucco, Massimo, Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes.
상세보기
Nuwayser,Elie S., Multi-layered microcapsules and method of preparing same.
상세보기
Mathiowitz, Edith; Jacob, Jules S.; Chickering, III, Donald E.; Leach, Kathleen Jo, Multiwall polymeric microcapsules from hydrophilic polymers.
상세보기
Mathiowitz Edith ; Langer Robert S., Multiwall polymeric microspheres.
상세보기
Ellis-Behnke, Rutledge; Ling, Patrick Ming Tat, Nano cancer barrier device (NCBD) to immobilize and inhibit the division of metastic cancer stem cells.
상세보기
Cha, Jennifer; Deming, Timothy J.; Stucky, Galen D.; Wong, Michael; Birkedal, Henrik; Bartl, Michael H.; Sumerel, Jan L., Nanoparticle assembled hollow spheres.
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Brown, Larry R.; Scott, Terrence L.; Lafreniere, Debra; Bisker-Leib, Vered, Nucleic acid microspheres, production and delivery thereof.
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Scott, Terrence; Lafreniere, Debra; Bisker-Leib, Vered; Brown, Larry, Nucleic acid microspheres, production and delivery thereof.
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Chen, Lieping, Nucleic acid molecules encoding B7-DC variants.
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Basu,Sujit K.; Hrkach,Jeffrey; Lipp,Michael; Elbert,Katharina; Edwards,David A., Particles for inhalation having sustained release properties.
상세보기
Edwards, David A.; Hrkach, Jeffrey S., Particles for inhalation having sustained release properties.
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Edwards, David A.; Langer, Robert S.; Vanbever, Rita; Mintzes, Jeffrey; Wang, Jue; Chen, Donghao, Particles for inhalation having sustained release properties.
상세보기
Vanbever,Rita; Langer,Robert S.; Edwards,David A.; Mintzes,Jeffrey; Wang,Jue; Chen,Donghao, Particles for inhalation having sustained release properties.
상세보기
Masterman Thomas C. (Boston MA) Spencer Jean L. (Boston MA), Particles including degradable material and anti-microbial agent.
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Batycky,Richard P.; Edwards,David A.; Lipp,Michael M., Particulate compositions for pulmonary delivery.
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Batycky,Richard P.; Edwards,David A.; Lipp,Michael M., Particulate compositions for pulmonary delivery.
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Anderson, Richard R.; Mlynarczyk, Susanna K.; Drill, Craig A., Permanent, removable tissue markings.
상세보기
Anderson, Richard R.; Mlynarczyk, Susanna K.; Drill, Craig A., Permanent, removable tissue markings.
상세보기
Anderson, Richard R.; Mlynarczyk, Susanna K.; Drill, Craig A., Permanent, removable tissue markings.
상세보기
Anderson,Richard Rox; Mlynarczyk Evans,Susanna K.; Drill,Craig A., Permanent, removable tissue markings.
상세보기
Anderson,Richard Rox; Mlynarczyk Evans,Susanna K.; Drill,Craig A., Permanent, removable tissue markings.
상세보기
Anderson,Richard Rox; Mlynarczyk Evans,Susanna K.; Drill,Craig A., Permanent, removable tissue markings.
상세보기
Duffy, Patrick; Jorgensen, Ellen Dias; Boger, Erich; Mathiowitz, Edith, Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof.
상세보기
Duffy, Patrick; Jorgensen, Ellen Dias; Boger, Erich; Mathiowitz, Edith, Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof.
상세보기
Duffy, Patrick; Jorgensen, Ellen Dias; Boger, Erich; Mathiowitz, Edith, Personalizing substance for application to the skin or addition to tattoo ink and methods of preparation thereof.
상세보기
Ragavan Vanaja V. ; DiPiano Gerrianne M., Pharmaceutical preparations and methods for their administration.
상세보기
Ragavan, Vanaja V.; DiPiano, Gerianne M., Pharmaceutical preparations and methods for their regional administration.
상세보기
Vanaja V. Ragavan ; Gerianne M. DiPiano, Pharmaceutical preparations and methods for their regional administration.
상세보기
DiPiano, Gerianne T.; Mays, Peter Kevin; Ziemniak, John, Pharmaceutical preparations for treatments of diseases and disorders of the breast.
상세보기
DiPiano, Gerianne Tringali; Mays, Peter Kevin; Ziemniak, John, Pharmaceutical preparations for treatments of diseases and disorders of the breast.
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Borodic,Gary, Pharmaceuticaltoxin compositions.
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Weers, Jeffry G.; Tarara, Thomas E.; Dellamary, Luis A.; Riess, Jean G.; Schutt, Ernest G., Phospholipid-based powders for drug delivery.
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Weers, Jeffry G; Tarara, Thomas E; Dellamary, Luis A; Riess, Jean G; Schutt, Ernest G, Phospholipid-based powders for drug delivery.
상세보기
Chen,Ching Jen; Haik,Yousef; Chatterjee,Jhunu, Polymeric encapsulation of nanoparticles.
상세보기
Edith Mathiowitz ; Yong Shik Jong KR; Kim Boekelheide, Polymeric gene delivery.
상세보기
Mathiowitz Edith ; Jong Yong Shik,KRX ; Boekelheide Kim, Polymeric gene delivery system.
상세보기
Mathiowitz, Edith; Jong, Yong Shik; Boekelheide, Kim, Polymeric gene delivery system.
상세보기
Boss, Anders Hasager; Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W., Potentiation of glucose elimination.
상세보기
Boss, Anders Hasager; Steiner, Solomon S.; Woods, Rodney J.; Sulner, Joseph W., Potentiation of glucose elimination.
상세보기
Mathiowitz Edith ; Jacob Jules S. ; Chickering ; III Donald E. ; Pekarek Kathleen Jo, Preparation of multiwall polymeric microcapsules from hydrophilic polymers.
상세보기
Mathiowitz, Edith; Jacob, Jules S.; Chickering, III, Donald E.; Pekarek, Kathleen Jo, Preparation of multiwall polymeric microcapsules from hydrophilic polymers.
상세보기
Edwards, David A.; Langer, Robert S.; Vanbever, Rita; Mintzes, Jeffrey; Wang, Jue; Chen, Donghao, Preparation of novel particles for inhalation.
상세보기
Edwards David A. ; Langer Robert S. ; Vanbever Rita ; Mintzes Jeffrey ; Wang Jue ; Chen Donghao, Preparation of particles for inhalation.
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Plate Nicolai A.,RUX ; Valuev Lev I.,RUX ; Uzhinova Lubov D.,RUX ; Sinani Vladimir A.,RUX, Process for preparing biologically compatible polymers and their use in medical devices.
상세보기
Mathiowitz Edith ; Chickering ; III Donald ; Jong Yong S. ; Jacob Jules S., Process for preparing microparticles through phase inversion phenomena.
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Mathiowitz, Edith; Chickering, III, Donald; Jong, Yong S.; Jacob, Jules S., Process for preparing microparticles through phase inversion phenomena.
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Sengupta, Tapashi; Fernandez, Douglas A.; Mishra, Munmaya K.; Sweeney, William R.; Yang, Szu-Sung, Production of coated tobacco particles suitable for usage in a smokeless tobacoo product.
상세보기
Sengupta, Tapashi; Mishra, Munmaya K.; Sweeney, William R.; Fernandez, Douglas A., Production of micronized encapsulated tobacco particles for tobacco flavor delivery from an oral pouch.
상세보기
Brown,Larry R., Production of microspheres.
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Goldenheim Paul ; Lacouture Peter ; Donigi-Gale Donna ; Chasin Mark ; Sackler Richard, Prolonged anesthesia in joints and body spaces.
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Goldenheim, Paul; Donigi-Gale, Donna; Sackler, Richard; Lacouture, Peter; Chasin, Mark, Prolonged anesthesia in joints and body spaces.
상세보기
Sackler Richard ; Goldenheim Paul ; Chasin Mark, Prolonged local anesthesia with colchicine.
상세보기
Bernstein Howard (Cambridge MA) Morrel Eric (Needham MA) Mathiowitz Edith (Brookline MA) Schwaller Kirsten (Duxbury MA) Beck Thomas R. (Concord MA), Protein microspheres and methods of using them.
상세보기
Brown, Larry; Bisker-Leib, Vered; LaFreniere, Debra; McGeehan, John; Rashba-Step, Julia; Scott, Terrence, Protein microspheres having injectable properties at high concentrations.
상세보기
Brown, Larry R.; Yang, Mark X.; O'Connell, Ed, Protein microspheres retaining pharmacokinetic and pharmacodynamic properties.
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Patton,John S., Pulmonary delivery of active fragments of parathyroid hormone.
상세보기
Tarara, Thomas E.; Weers, Jeffry G.; Venthoye, Geraldine, Pulmonary delivery of aminoglycoside.
상세보기
Tarara, Thomas E; Weers, Jeffry G; Venthoye, Maria Geraldine, Pulmonary delivery of aminoglycoside.
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Tarara, Thomas E.; Weers, Jeffrey G.; Kabalnov, Alexey; Schutt, Ernest G.; Dellamary, Luis A., Pulmonary delivery particles comprising an active agent.
상세보기
Steiner, Solomon S.; Pohl, Roderike, Rapid acting and long acting insulin combination formulations.
상세보기
Steiner, Solomon S.; Pohl, Roderike, Rapid acting and long acting insulin combination formulations.
상세보기
Pohl, Roderike; Steiner, Solomon S., Rapid acting injectable insulin compositions.
상세보기
Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis A.; Tarara, Thomas E.; Kabalnov, Alexey, Respiratory dispersion for metered dose inhalers comprising perforated microstructures.
상세보기
Roser, Bruce J.; Colaco, Camilo; Jerrow, Mohammed A. Z.; Blair, Julian; Kampinga, Jaap; Wardell, James Lewis; Duffy, John Alistair, Solid delivery systems for controlled release of molecules incorporated therein and methods of making same.
상세보기
Roser Bruce J.,GBX ; Kampinga Jaap,NLX ; Colaco Camilo,GBX ; Blair Julian,GBX, Solid dose delivery vehicle and methods of making same.
상세보기
Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
상세보기
Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
상세보기
Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
상세보기
Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
상세보기
Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
상세보기
Roser, Bruce J.; Kampinga, Jaap; Colaco, Camilo; Blair, Julian, Solid dose delivery vehicle and methods of making same.
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Roser,Bruce J.; Kampinga,Jaap; Colaco,Camilo; Blair,Julian, Solid dose delivery vehicle and methods of making same.
상세보기
Weers, Jeffry G.; Schutt, Ernest G.; Dellamary, Luis; Tarara, Thomas E.; Kabalnov, Alexey, Stabilized preparations for use in metered dose inhalers.
상세보기
Dellamary, Luis A.; Reiss, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery.
상세보기
Dellamary, Luis A.; Riess, Jean; Schutt, Ernest G.; Weers, Jeffry G.; Tarara, Thomas E., Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
상세보기
Dellamary, Luis A; Riess, Jean; Schutt, Ernest G; Weers, Jeffry G; Tarara, Thomas E, Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use.
상세보기
Edwards, David A.; Hrkach, Jeffrey S., Stable spray-dried protein formulations.
상세보기
Kraft, Kelly Sullivan, Substituted diketopiperazine analogs for use as drug delivery agents.
상세보기
Kraft, Kelly Sullivan, Substituted diketopiperazine analogs for use as drug delivery agents.
상세보기
Kraft, Kelly Sullivan, Substituted diketopiperazine analogs for use as drug delivery agents.
상세보기
Chen Jianbing ; Ashton Paul, Sustained release drug delivery devices.
상세보기
Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
상세보기
Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
상세보기
Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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Guo, Hong; Ashton, Paul, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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Hong Guo ; Paul Ashton, Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof.
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Tseng Mingchih M. ; Philbrook Carl M., Sustained-release matrices for dental application.
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Tseng Mingchih M. ; Philbrook Carl M., Sustained-release matrices for dental application.
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Klitzman Bruce ; Koger Kim Edward, Tattoo inks.
상세보기
Chenite, Abdellatif; Chaput, Cyril; Wang, Dong; Selmani, Amine, Temperature controlled and pH dependent self gelling biopolymeric aqueous solution.
상세보기
Borodic, Gary E., Topical ocular preparation of botulinum toxin for use in ocular surface disease.
상세보기
Ellis-Behnke, Rutledge; Norchi, Terrence W.; Kelly, Stephen Richard, Treatment of leaky or damaged tight junctions and enhancing extracellular matrix.
상세보기
Richardson, Peter; Baughman, Robert A.; Potocka, Elizabeth; Boss, Anders Hasager; Petrucci, Richard, Use of ultrarapid acting insulin.
상세보기
DiPiano, Gerianne Tringali; Ziemniak, John A.; Janicki, Thomas, Vaginal delivery of drugs.
상세보기
Yan, Cuie; Zhang, Wei; Jin, Yulai; Demont, Lesek Alexa; Barrow, Colin James, Vegetarian microcapsules.
상세보기
Bonsignore Patrick V. (Joliet IL) Coleman Robert D. (Wheaton IL), Water and UV degradable lactic acid polymers.
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IPC	Description
A	생활필수품
A62	인명구조; 소방(사다리 E06C)
A62B	인명구조용의 기구, 장치 또는 방법(특히 의료용에 사용되는 밸브 A61M 39/00; 특히 물에서 쓰이는 인명구조 장치 또는 방법 B63C 9/00; 잠수장비 B63C 11/00; 특히 항공기에 쓰는 것, 예. 낙하산, 투출좌석 B64D; 특히 광산에서 쓰이는 구조장치 E21F 11/00)
A62B-1/08	.. 윈치 또는 풀리에 제동기구가 있는 것

내보내기 구분	파일저장 인쇄 메일전송
구성항목	기본정보 상세정보 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표IPC 관리번호, 국가코드, 자료구분, 상태, 출원번호, 출원일자, 공개번호, 공개일자, 공고번호, 공고일자, 등록번호, 등록일자, 발명명칭(한글), 발명명칭(영문), 출원인(한글), 출원인(영문), 출원인코드, 대표출원인, 출원인국적, 출원인주소, 발명자, 발명자E, 발명자코드, 발명자주소, 발명자 우편번호, 발명자국적, 대표IPC, IPC코드, 요약, 미국특허분류, 대리인주소, 대리인코드, 대리인(한글), 대리인(영문), 국제공개일자, 국제공개번호, 국제출원일자, 국제출원번호, 우선권, 우선권주장일, 우선권국가, 우선권출원번호, 원출원일자, 원출원번호, 지정국, Citing Patents, Cited Patents
저장형식	Text(ASCII format) Excel format PIAS분석(.xls)
메일정보	받는사람 (필수) @ 보내는사람 (선택) @ 제목 내용 KISTI 검색결과 이메일 서비스
안내	총 건의 자료가 검색되었습니다. 다운받으실 자료의 인덱스를 입력하세요. (1-10,000) 검색결과의 순서대로 최대 10,000건 까지 다운로드가 가능합니다. 데이타가 많을 경우 속도가 느려질 수 있습니다.(최대 2~3분 소요) 다운로드 파일은 UTF-8 형태로 저장됩니다. 파일의 내용이 제대로 보이지 않을실 때는 웹브라우저 상단의 보기 -> 인코딩 -> 자동선택 여부를 확인하십시오. ~ Text(ASCII format) Excel format

연합인증

Preparation of multiwall polymeric microcapsules 원문보기