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특허 상세정보

Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols

특허상세정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판) A01N-061/00    A61K-031/00   
미국특허분류(USC) 514/784 ; 514/947 ; 514/772 ; 514/785
출원번호 US-0218702 (1988-07-13)
발명자 / 주소
출원인 / 주소
인용정보 피인용 횟수 : 165  인용 특허 : 9
초록

Penetration-enhancing pharmaceutical compositions for topical transepidermal and percutaneous application are disclosed which are non-irritating to the skin. These compositions are made up of a safe and effective amount of an active pharmaceutical permeant, including hydrophilic salt forms, contained in a novel penetration-enhancing vehicle comprising, (i) 1-95% w. of a cell-envelope disordering compound selected from the group consisting of oleic acid, oleyl alcohol, glycerol monoleate, glycerol dioleate, glycerol trioleate and mixtures thereof, (ii) 5-...

대표
청구항

A pharmaceutical composition for topical application having penetration-enhancing properties consisting essentially of: (a) a safe and effective amount of an active pharmaceutical agent contained in, (b) a penetration-enhancing vehicle exclusive of diols and N-cyclic solvents consisting essentially of: (i) 1-95% by weight of one or more cell-envelope disordering compounds selected from the group consisting of oleic acid, oleyl alcohol, glycerol esters of oleic acid and mixtures thereof; (ii) 5-75% by weight of a lower alkanol selected from the group cons...

이 특허에 인용된 특허 (9)

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