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Antibody-therapeutic agent conjugates 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61K-039/00
  • A61K-037/00
  • A23J-037/00
출원번호 US-0650375 (1984-09-13)
발명자 / 주소
  • Goers John W. F. (Atascadero CA) King Hurley D. (Yardley PA) Lee Chyi (New Brunswick NJ) Coughlin Daniel J. (Plainsboro NJ) Alvarez Vernon L. (Morrisville PA) Rodwell John D. (Yardley PA) McKearn Tho
출원인 / 주소
  • Cytogen Corporation (Princeton NJ 02)
인용정보 피인용 횟수 : 189  인용 특허 : 9

초록 ▼

This invention relates to antibody-therapeutic agent conjugates having a therapeutic agent covalently attached to an antibody or antibody fragment. Also described are methods for intermediates in the preparation of antibody conjugates. Therapeutic in vivo methods utilizing such antibody-therapeutic

대표청구항 ▼

A method for preparing a pharmaceutical antibody-therapeutic agent conjugate composition suitable for in vivo administration and for the in vivo delivery of a therapeutic agent, comprising: (a) reacting an antibody or antibody fragment with an oxidizing agent to form an aldehyde group in a carbohydr

이 특허에 인용된 특허 (9)

  1. Rodwell John D. (Yardley PA) McKearn Thomas J. (Narberth PA), Antibody conjugates for the delivery of compounds to target sites.
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  3. Ali Majid (19 Edgemont Pl. Teaneck NJ 07666) Nalebuft Donald (89 Lake Shore Dr. Oakland NJ 07436) Fayemi Alfred (15 Francine Ct. White Plains NY 10607) Ramanarayanan Madhava P. (100 Haven Ave. New Yo, Enzyme immunoassay for allergic disorders.
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  5. Sela ; Michael ; Arnon ; Ruth ; Maron ; Ruth ; Hurvitz ; Esther, Immunologic chemotherapeutic agents comprising antigen binding dimers covalently bound to drugs.
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  6. Quash Gerard A. (Sainte Foy Les Lyon FRX), Novel supports carrying side chains, processes for obtaining these supports, process for attaching organic compounds hav.
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  7. Quash Gerard A. (Sainte Foy les Lyon FRX), Novel supports carrying side chains, processes for obtaining these supports, process for attaching organic compounds hav.
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  8. Sela Michael (Rehovot ILX) Arnon Ruth (Rehovot ILX) Hurvitz Esther (Rehovot ILX) Maron Ruth (Tel Aviv ILX) Levy Ron (Rehovot ILX), Pharmaceutically active compositions containing adriamycin and daunomycin.
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  9. Kotani Kikuo (Shizuoka JPX) Ohyama Kunio (Shizuoka JPX) Nakagawa Nobuaki (Shizuoka JPX) Fujii Tadashiro (Mishima JPX) Watanabe Susumu (Shizuoka JPX), Polyfunctional disulfide compounds having S－S exchange reactivity.
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