초록 ▼

The selection of: a hydrophobic carbohydrate polymer, e.g. ethyl cellulose; and, generally at least one digestive-difficulty soluble component, i.e. a wax, e.g. carnauba wax, fatty acid material or neutral lipid provides upon dry direct compression a controlled and continuous release matrix for tabl

The selection of: a hydrophobic carbohydrate polymer, e.g. ethyl cellulose; and, generally at least one digestive-difficulty soluble component, i.e. a wax, e.g. carnauba wax, fatty acid material or neutral lipid provides upon dry direct compression a controlled and continuous release matrix for tablets or implants of biologically active agents. Preferred for producing dry direct compressed products is the combination of: a hydrophobic cellulose derivative; a wax, and, a fatty acid material and/or a neutral lipid since it provides upon dry direct compression a controlled and continuous release tablet or implant of improved structurally integrity against externally imposed forces.

대표청구항 ▼

A dry, direct compressed product containing controlled release dosage forms of therapeutically active particulate agents produced without heat or solvents by the steps comprising: (a) dry blending blend particles, all of which have particle sizes smaller than 20 mesh, consisting essentially of from

A dry, direct compressed product containing controlled release dosage forms of therapeutically active particulate agents produced without heat or solvents by the steps comprising: (a) dry blending blend particles, all of which have particle sizes smaller than 20 mesh, consisting essentially of from 0.01 to 95 weight parts of biologically active particulate solids with from 5 to 99.99 weight parts of a matrix blend combination consisting essentially of from 1 to 96 parts by weight of a hydrophobic carbohydrate polymer of the class of ethyl cellulose, propyl cellulose, cellulose acetate, cellulose propionate, cellulose acetatebutryate and cellulose acetate-propionate and from 4 to 99 parts by weight of a digestive-difficulty soluble component of the class consisting of a wax of the class consisting of carnauba wax, spermceti, beeswax, candelilla wax, esparto and paraffins; a fatty acid material of the class consisting of fatty acids having from 12 to 28 carbon atoms, fatty monoalchols having 12 to 28 carbon atoms, fatty amines and amides having from 12 to 28 carbon atoms; a neutral lipid of the class consisting of stearin, palmitin, castorwax, phospholipids, glycolipids, glycerides, hydrogenated cottonseed oil, hydrogenated cottonseed oil, hydrogenated tallow and metal and organic salts of C11-C28 fatty acids: and, mixtures thereof; (b) compressing said blended solids and blend under a pressure of 1.5 to 20 tons per square inch; and (c) thereafter, recovering said compressed product having a hardness of 4 to 25 kg and excellent resistance to delamination when subjected to an external longitudinal force.