초록 ▼

A non-invasive apparatus and related method for measuring the concentration of glucose or other blood analytes utilizes both diffuse reflected and transmissive infrared absorption measurements and may be applied to either in vitro or in vivo sampling. The apparatus and method utilize non-dispersive

A non-invasive apparatus and related method for measuring the concentration of glucose or other blood analytes utilizes both diffuse reflected and transmissive infrared absorption measurements and may be applied to either in vitro or in vivo sampling. The apparatus and method utilize non-dispersive correlation spectrometry and apply it to liquid blood serum analysis. Spectrally-modified near infrared light from the sample containing the analyte is split into two beams, one of which is directed through a negative correlation filter which blocks light in the absorption bands for the analyte to be measured, and the other of which is directed through a neutral density filter capable of blocking light equally at all wavelengths in the range of interest. Differencing the light intensity between the two light paths provides a measure proportional to analyte concentration.

대표청구항 ▼

A method for the non-invasive measurement of the concentration of a blood analyte comprising the steps of: (a) directing a beam of near infrared light to a source containing the blood analyte to be measured; (b) causing the beam to be transmitted or reflected by the source so as to provide a spectra

A method for the non-invasive measurement of the concentration of a blood analyte comprising the steps of: (a) directing a beam of near infrared light to a source containing the blood analyte to be measured; (b) causing the beam to be transmitted or reflected by the source so as to provide a spectrally-modified beam; (c) directing the modified beam into two paths; (d) directing the modified beam of one path through a first optical filter having an absorption spectra of the analyte sufficient to block light for the maximum expected concentration of the analyte; (e) directing the modified beam of the other path through a second optical filter having an absorption spectra sufficient to block light equally at all wavelengths; (f) measuring the relative intensity of the beam from each path exiting its respective optical filter; (g) generating a signal representative of the difference in intensity between the beams; and, (h) converting the signal into an indication of analyte concentration.