초록

A porous composite membrane comprises a base membrane of high mechanical strength and a coating of a hydrophilic polymer on the surface of the membrane and on the walls of the pores. The invention includes a method to prepare the membrane and a biosensor including the membrane.

대표청구항 ▼

A method for preparing a hydrophilic ion permeable membrane comprising: (a) steeping a polyolefinic base screen membrane filter having a pore therethrough in a bath of a monomer of a hydrophilic polymer whereby a coating of said monomer forms on said base membrane and a wall of said pore, and said m

A method for preparing a hydrophilic ion permeable membrane comprising: (a) steeping a polyolefinic base screen membrane filter having a pore therethrough in a bath of a monomer of a hydrophilic polymer whereby a coating of said monomer forms on said base membrane and a wall of said pore, and said monomer permeates into, the matrix of said base membrane; (b) removing said base membrane having said coating thereon from said bath and (c) treating said based membrane having said coating of monomer thereon with a plasma whereby said monomer is polymerized to a crosslinked hydrophilic polymer thereby rendering said membrane hydrophilic and ion permeable. A hydrophilic ion permeable screen membrane filter comprising a polyolefinic base membrane having a pore therethrough and a coating of an interpenetrating polymeric network type crosslinked hydrophilic polymer on said base membrane and on a wall of said pore, said polymer being selected from the group consisting of polyacrylic acid, polyhy droxyethylacrylate and polyvinylpyrrolidone, said membrane having a hydrogen ion diffusion constant of greater than 7.8×10-10. A sensor for blood analysis comprising a sensing element which includes a field effect transistor sensitive to the pH of a blood stream and a composite membrane having a hydrogen ion diffusion constant of greater than 7.8×10-10 comprising a polypropylene base screen membrane filter having a pore therethrough and a coating of an interpenetrating polymeric network type crosslinked polyacrylic acid on said base membrane and on a wall of said pore, said composite membrane being permeable to hydrogen ions in a blood stream but impermeable to other components of said blood stream, said transistor being capable of generating a detectable signal consequent to contact with said hydrogen ions.