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Flow-through methods and apparatus for iontophoresis application of medicaments at a controlled pH

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61N-001/30
출원번호 US-0064813 (1987-06-19)
발명자 / 주소
  • Jacobsen Stephen C. (274 S. 1220 East Salt Lake City UT 84102) Petelenz Tomasz J. (623 University Village UT 84108) Stephen Robert L. (2501 Kensington Ave. Salt Lake City UT 84108)
인용정보 피인용 횟수 : 36  인용 특허 : 21

초록

Methods and apparatus for administering known quantities of medicaments by iontophoresis, while avoiding burns caused by extremes in the pH of the medicament medium during passage of an electric current, are disclosed. It is known that as iontophoresis progresses in conventional iontophoresis system

대표청구항

A method for iontophoretically administering a medicament through the skin of a patient while removing competing ions produced within the iontophoresis system by the electrolysis of water, the method comprising the steps of: (a) obtaining a first electrode and a second electrode; (b) obtaining a med

이 특허에 인용된 특허 (21)

  1. Sibalis, Dan, Applicator for the non-invasive transcutaneous delivery of medicament.
  2. Bremer Roger E. (Fort Lee NJ) Falb Richard D. (Bristol IN), Biomedical electrode with pressurized skin contact.
  3. Ellis Franklin H. (Rochester NY), Electric supply for ion therapy.
  4. Gomes Robert L. (West Boxford MA) Maffione Joseph P. (Cambridge MA), Electrode.
  5. Storm ; III Frederick K. (11400 Albata St. Los Angeles CA 90049), Electrode structure for radio frequency localized heating of tumor bearing tissue.
  6. Jacobsen Stephen C. (Salt Lake City UT) Stephen Robert L. (Salt Lake City UT) Johnson R. Todd (Salt Lake City UT) Luntz Richard (Salt Lake City UT) Knutti David (Salt Lake City UT), Epidermal iontophoresis device.
  7. Jacobsen Stephen C. (Salt Lake City UT) Stephen Robert L. (Salt Lake City UT) Luntz Richard D. (Salt Lake City UT) Johnson Richard T. (Salt Lake City UT) Knutti David F. (Salt Lake City UT) Mandleco , Fluid self-sealing bioelectrode.
  8. Rizk Nabil I. (229 Haymont Dr. Gibsonia PA 15044) Stevens Charles L. (Pittsburgh PA), Implantable electrophoretic pump for ionic drugs and associated methods.
  9. Jacobsen Stephen C. (Salt Lake City UT) Luntz Richard D. (Murray UT), Ion mobility limiting iontophoretic bioelectrode.
  10. Phipps Joseph B. (Plymouth MN) Untereker Darrel F. (Cedar MN), Iontophoresis apparatus and methods of producing same.
  11. Vernon Jack A. (Portland OR) Kaufman Murlan R. (Portland OR) Brummett Robert E. (Milwaukie OR) Bender Herman G. (Portland OR), Iontophoresis apparatus for applying local anesthetics.
  12. Ariura Shunsuke (Matsudo JPX) Ogata Tadashi (Fuchu JPX) Kashima Norie (Tokyo JPX) Morihata Michiyo (Fuchu JPX), Iontophoresis device.
  13. Csillik Bertalan (Szeged) Knyihr Erzsbet (Szeged) Szcs Attila (Szeged), Iontophoresis intermediary material and contact solution for the treatment of chronic pain syndromes.
  14. Phipps Joseph B. (Plymouth MN) Untereker Darrel F. (Cedar MN), Iontophoretic drug delivery.
  15. Webster, Henry L., Iontophoretic electrode device, method and gel insert.
  16. Jacobsen Stephen C. (Salt Lake City UT) Luntz Richard D. (Murray UT) Hanover Barry K. (Salt Lake City UT), Iontophoretic electrode structure.
  17. Jacobsen Stephen C. (Salt Lake City UT) Luntz Richard D. (Murray UT) Hanover Barry K. (Salt Lake City UT), Iontophoretic electrode structure.
  18. Bremer Roger E. (Fort Lee NJ) Anthony ; Jr. Charles (Livingston NJ) Chappel Raymond M. (Mendham NJ), Long-life biomedical application device, particularly electrode, and method of transferring electrical current.
  19. Sanderson John E. (North Miami FL) Deriel Stanton R. (Pembroke Pines FL), Method and apparatus for iontophoretic drug delivery.
  20. Buchalter Gilbert (28 Mountainview Rd. Millburn NJ 07041), Method of applying an electrode to the skin of a patient.
  21. Jacobsen Stephen C. (Salt Lake City UT) Stenehjem Jerome C. (Salt Lake City UT) Stephen Robert L. (Salt Lake City UT) Luntz Richard D. (Murray UT), Non-invasive chemical species delivery apparatus and method.

이 특허를 인용한 특허 (36)

  1. Yanaki, Jamal S., Active electrode for transdermal medicament administration.
  2. Yanaki, Jamal S., Active transdermal medicament patch and circuit board for same.
  3. Imran, Mir, Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use.
  4. Imran, Mir, Corrosion resistant electrodes for iontophoretic transdermal delivery devices and methods of use.
  5. Sage, Jr., Burton H.; Bock, Carl R., Device and method for renewing electrodes during iontophoresis.
  6. Stryker, Martin W.; Engelman, Donald M., Drug delivery system.
  7. Murdock Thomas O., Enhanced electrotransport of therapeutic agents having polybasic anionic counter ions.
  8. Atanasoska Ljiljana, Iontophoresis electrode.
  9. Hamlin Robert ; Clapp Robert ; Burgmeier Robert E., Iontophoresis electrode.
  10. Imran, Mir, Iontophoretic apparatus and method for marking of the skin.
  11. Imran, Mir, Iontophoretic apparatus and method for marking of the skin.
  12. Joshi,Ashok V., Iontophoretic drug delivery systems.
  13. Imran, Mir, Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes.
  14. Imran, Mir, Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes.
  15. Imran, Mir, Iontophoretic system for transdermal delivery of active agents for therapeutic and medicinal purposes.
  16. Phipps Joseph B., Method and apparatus for controlled environment electrotransport.
  17. Phipps Joseph B., Method and apparatus for controlled environment electrotransport.
  18. Phipps Joseph B. (Plymouth MN), Method and apparatus for controlled environment electrotransport.
  19. Imran, Mir, Method and apparatus for oscillatory iontophoretic transdermal delivery of a therapeutic agent.
  20. Imran, Mir; Hashim, Mir; Patel, Sanjay; Berenson, Ronald J., Method for transdermal iontophoretic delivery of chelated agents.
  21. Imran, Mir; Hashim, Mir; Patel, Sanjay; Berenson, Ronald J., Method for transdermal iontophoretic delivery of chelated agents.
  22. Imran, Mir A.; Andersen, Dean P.; Malhotra, Vikram; Mangogna, George Andrew, Methods and architecture for power optimization of iontophoretic transdermal drug delivery.
  23. Imran, Mir, Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes.
  24. Imran, Mir A., Patch and patch assembly for iontophoretic transdermal delivery of active agents for therapeutic and medicinal purposes.
  25. Berenson, Ronald J., Patches and method for the transdermal delivery of a therapeutically effective amount of iron.
  26. Berenson, Ronald J., Patches and methods for the transdermal delivery of a therapeutically effective amount of iron.
  27. Kraft, Edward R.; Kulp, Gabriela, Photokinetic delivery of biologically active substances using pulsed incoherent light.
  28. Kraft,Edward R.; Kulp,Gabriela, Photokinetic delivery of biologically active substances using pulsed incoherent light.
  29. Gupta Suneel K. ; Haak Ronald P., Programmed adjustment of electric current to provide desired electrically assisted transdermal drug delivery rate.
  30. Imran, Mir; Hashim, Mir; McLaughlin, Glen; Arastu, Huma; Vaidyanathan, Rekha; Harris, Joel; Korupolu, Radhika; Mangogna, Andrew; Ong, Chang; Patel, Sanjay; Wang, Lu; Williams, Timothy, System and method for biphasic transdermal iontophoretic delivery of therapeutic agents.
  31. Imran, Mir A.; Imran, Talat; Hashim, Mir, System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings.
  32. Imran, Mir; Imran, Talat; Hashim, Mir, System and method for biphasic transdermal iontophoretic delivery of therapeutic agents for the control of addictive cravings.
  33. Imran, Mir; Hashim, Mir; McLaughlin, Glen; Arastu, Huma; Vaidyanathan, Rekha; Harris, Joel; Korupolu, Radhika; Mangogna, Andrew; Ong, Chang; Patel, Sanjay; Wang, Lu; Williams, Timothy, System and method for biphasic transdermal iontophreotic delivery of therapeutic agents.
  34. Imran, Mir A.; Imran, Talat; Hashim, Mir, System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation.
  35. Imran, Mir; Imran, Talat; Hashim, Mir, System and method for controlling the iontophoretic delivery of therapeutic agents based on user inhalation.
  36. Miller, David J.; Li, Kevin; Higuchi, William I., Use of background electrolytes to minimize flux variability during iontophoresis.
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