초록 ▼

An improved process for the preparation of mineral/collagen/OF (osteogenic factor) inductive implants for bone repair utilizes drying, under ambient pressure conditions, a suspension of 75-95% mineral particles, 5-25% collagen, and an effective amount of OF, such as 0.5-4% partially purified OFE or

An improved process for the preparation of mineral/collagen/OF (osteogenic factor) inductive implants for bone repair utilizes drying, under ambient pressure conditions, a suspension of 75-95% mineral particles, 5-25% collagen, and an effective amount of OF, such as 0.5-4% partially purified OFE or its equivalent wherein the concentration of collagen in the suspension subjected to drying is 30-100 mg/ml. The resulting implants are improved. They are homogeneous in composition and have a high compressive modulus as well as containing OF in a biologically active and available form.

대표청구항 ▼

A process for preparing a hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate wherein the composition comprises an osteoinductively effective amount of a protein osteoinductive factor (OF), which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic ho

A process for preparing a hypoimmunogenic composition suitable for implantation to effect bone repair in a vertebrate wherein the composition comprises an osteoinductively effective amount of a protein osteoinductive factor (OF), which OF is sufficiently pure to be hypoimmunogenic in a xenogeneic host, and a carrier having components which consist essentially of mineral constituting 60-98% and collagen constituting 2-40% of the composition, which process comprises: (a) preparing a uniform suspension in water of the collagen, mineral, and OF components of the composition so that the concentration of collagen in the suspension is 30-100 mg/ml; and (b) subjecting the suspension to controlled drying under ambient pressure to obtain a rigid solid.