초록 ▼

A medical device having long-lasting bactericidal properties and a method for making the same is provided. The material from which the medical device is made, the substrate, carries a negatively-charged group having a pKa of less than 6. A cationic antibiotic is ionically bonded to the negatively-ch

A medical device having long-lasting bactericidal properties and a method for making the same is provided. The material from which the medical device is made, the substrate, carries a negatively-charged group having a pKa of less than 6. A cationic antibiotic is ionically bonded to the negatively-charged group. The negatively-charged group may be a portion of a larger carrier molecule. The carrier molecule is bound to the substrate such that the negatively-charged group is exposed for ionic interaction with the cationic antibiotic. Heparin is an ideal carrier molecule because it has both anti-bacterial adhesion activity and anti-thrombogenic activity.

대표청구항 ▼

A medical device having long-lasting bactericidal properties comprising, a substrate, heparin molecules ionically bound to said substrate via anchor molecules, said anchor molecules attached directly to said substrate and interposed between said heparin molecules and said substrate, said anchor mole

A medical device having long-lasting bactericidal properties comprising, a substrate, heparin molecules ionically bound to said substrate via anchor molecules, said anchor molecules attached directly to said substrate and interposed between said heparin molecules and said substrate, said anchor molecules selected from the group consisting of BZK and TDMAC, and cationic antibiotic molecules ionically bound to said heparin molecules.