초록 ▼

A diffusional drug delivery device is described which can provide shelf life stability of the system components, elimination of the initial burst of drug and hence irritation, delayed onset of therapeutic effect and delivery of a therapeutic agent at an optimum rate. A metal layer and an activating

A diffusional drug delivery device is described which can provide shelf life stability of the system components, elimination of the initial burst of drug and hence irritation, delayed onset of therapeutic effect and delivery of a therapeutic agent at an optimum rate. A metal layer and an activating means are inert when dry. Moisture activates the system whereby the activating means provides release of an eroding agent which erodes the metal layer through which the therapeutic agent diffuses and is subsequently delivered.

대표청구항 ▼

A controlled release medical device for delivery of a drug in a pre-determined delivery rate pattern to a biological environment comprising, in combination: reservoir means containing said drug having a surface through which the drug is released to the biological environment; a metal layer disposed

A controlled release medical device for delivery of a drug in a pre-determined delivery rate pattern to a biological environment comprising, in combination: reservoir means containing said drug having a surface through which the drug is released to the biological environment; a metal layer disposed between said reservoir means and the biological environment, wherein said metal layer in a first state is uneroded and, is substantially impermeable to the passage of said drug, and in a second stat is eroded and permeable to said drug; whereby substantially all of said drug must pass through said metal layer to reach the biological environment, and whereby the passage of drug to the biological environment by diffusion is impeded until the metal layer changes state.