Device for the compensation of the baseline drift of a chromatographic separating column
원문보기
IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0304865
(1989-01-31)
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우선권정보 |
DE-3323744 (1983-07-01) |
발명자
/ 주소 |
- Pospisil Peter (berlingen DEX) Kolb Bruno (Owingen DEX)
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출원인 / 주소 |
- The Perkin-Elmer Corporation (Norwalk CT 02)
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인용정보 |
피인용 횟수 :
8 인용 특허 :
5 |
초록
▼
The baseline drift occurring during a temperature or flow rate program in a chromatographic separating column is compensated for by signals from a function generator. The function generator supplies a computed baseline signal which is a representation of the baseline drift as an analytic function of
The baseline drift occurring during a temperature or flow rate program in a chromatographic separating column is compensated for by signals from a function generator. The function generator supplies a computed baseline signal which is a representation of the baseline drift as an analytic function of the temperature, computed with specific separating column parameters. The parameters are determined in a prior test run and inputted into the function generator.
대표청구항
▼
Device for the compensation of the baseline drift of a chromatographic separating column during a temperature and/or flow program, comprising, (a) a separating column, (b) programmer means, which are arranged to subject the separating column to predeterminable temperature and/or flowing programs, (c
Device for the compensation of the baseline drift of a chromatographic separating column during a temperature and/or flow program, comprising, (a) a separating column, (b) programmer means, which are arranged to subject the separating column to predeterminable temperature and/or flowing programs, (c) test run means for providing a first temperature and/or flow program without sample feeding for determination of a baseline depending on the temperature and on the flow and characteristic for the separating column, (d) a memory arranged to memorize data of the baseline thus determined, and (e) difference forming means, to which, during the subsequent execution of a second temperature and/or flow program with sample feeding and with the same separating column, a measuring signal corresponding to the output of the separating column and a baseline signal obtained from the memorized data for correction of the measuring signal are adapted to be applied, comprising, (i) computer means, to which the program parameters of the first temperature and/or flow program are applied by the test run means, and to which the uncorrected baseline signal obtained with this temperature and/or flow program without sample feeding is applied, and which are arranged to calculate parameters, a, b, ttq1, q2, q3, t1, t2, t3, R1, R2, of the temperature and/or flow program determined by the program supply means and of the parameters a, b, ttqq2, and q3 are column temperatures; t1, t2, and t3 are times; and R1 and R2 are increase rates.
이 특허에 인용된 특허 (5)
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Snyder Lloyd R. (Yorktown Heights NY), Chromatographic apparatus and method.
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Kruppa Richard F. (State College PA) Coleman Arthur Edward (Troy NY), High temperature polar stationary liquid phase for gas chromatography.
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McLafferty Fred W. (Ithaca NY) Baldwin Michael A. (Carshalton Beeches EN), Liquid chromatography-mass spectrometry system and method.
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DeFord Donald D. (Glenview IL) Clardy Edwin K. (Bartlesville OK) Fuller Edward N. (Bartlesville OK), Method and apparatus suitable for repeated, accurate chemical analyses.
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Kleiss Louis D. (Borger TX), Sloping baseline compensation for a chromatographic analyzer.
이 특허를 인용한 특허 (8)
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Klee Matthew S. ; Quimby Bruce D. ; Blumberg Leonid M., Automated retention time locking.
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Blaffert Thomas (Hamburg DEX) Dunand Nicholas C. (Cambridge GB2) Schoenmakers Petrus J. (Eindhoven NLX), Chromatography apparatus.
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Blumberg Leonid M. ; Broske Alan D., Column specific parameters for retention time locking in chromatography.
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Hajime Bungo JP, Detection device for apparatus for analysis.
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Lubowitz Hyman R. (Rolling Hills Estates CA) Sheppard Clyde H. (Bellevue WA) Stephenson Ronald R. (Kirkland WA), Method of making multidimensional polyesters.
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Choikhet, Konstantin, Method of reducing baseline instabilities in liquid chromatographic measurements and liquid chromatography apparatus.
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Magnus Fransson SE; Lars Karlsson SE; Bengt Lagerholm SE; Anders Sparen SE, Process control.
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Wylie Philip L. ; Crabtree James H. ; Weiner Kenneth R., Retention time-locked spectral database for target analyte analysis.
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